Uncertainties in the reference dose for methylmercury

被引：31

作者：

Dourson, ML ^{[1
]}

Wullenweber, AE ^{[1
]}

Poirier, KA ^{[1
]}

机构：

[1] TERA, Cincinnati, OH 45223 USA

来源：

NEUROTOXICOLOGY | 2001年 / 22卷 / 05期

关键词：

risk assessment; methylmercury; reference dose; toxicology; uncertainty factors;

D O I：

10.1016/S0161-813X(01)00060-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

This paper critically examines the National Academy of Sciences and the National Research Council report on the toxicological effects of methyl mercury and the recently published US Environmental Protection Agency Reference Dose (RfD) for Methylmercury. Particular scrutiny is placed on the choice of the critical study and the underlining assumptions utilized in the selection of specific uncertainty factors (UFs) and the rationale for using a less-than-default factor of 10. The UFs that were utilized or considered by other agencies and organizations are also critically examined, explained and compared to one another. Based on these analyses, the authors suggest research that could be performed that would ameliorate the uncertainty of choosing a more precise partial UF or that may even provide completeness of database to allow for selecting of a UF for unity, thus improving the precision of the current published RfD. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：677 / 689

页数：13

共 35 条

[1]

Agency for Toxic Substances and Disease Registry, 1999, TOX PROF MERC UPD

[2]

REFERENCE DOSE (RFD) - DESCRIPTION AND USE IN HEALTH RISK ASSESSMENTS [J].