Higher-Order Assemblies in a New Paradigm of Signal Transduction

被引:273
作者
Wu, Hao [1 ,2 ]
机构
[1] Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
CRYSTAL-STRUCTURE; RECEPTOR; COMPLEX; ACTIVATION; APOPTOSIS; MECHANISM; REVEALS; KINASE; TRAF6; FORMS;
D O I
10.1016/j.cell.2013.03.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.
引用
收藏
页码:287 / 292
页数:6
相关论文
共 24 条
[21]   Single-cell NF-κB dynamics reveal digital activation and analogue information processing [J].
Tay, Savas ;
Hughey, Jacob J. ;
Lee, Timothy K. ;
Lipniacki, Tomasz ;
Quake, Stephen R. ;
Covert, Markus W. .
NATURE, 2010, 466 (7303) :267-U149
[22]   The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations [J].
Wang, Liwei ;
Yang, Jin Kuk ;
Kabaleeswaran, Venkataraman ;
Rice, Amanda J. ;
Cruz, Anthony C. ;
Park, Ah Young ;
Yin, Qian ;
Damko, Ermelinda ;
Jang, Se Bok ;
Raunser, Stefan ;
Robinson, Carol V. ;
Siegel, Richard M. ;
Walz, Thomas ;
Wu, Hao .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (11) :1324-U176
[23]   E2 interaction and dimerization in the crystal structure of TRAF6 [J].
Yin, Qian ;
Lin, Su-Chang ;
Lamothe, Betty ;
Lu, Miao ;
Lo, Yu-Chih ;
Hura, Gregory ;
Zheng, Lixin ;
Rich, Rebecca L. ;
Campos, Alejandro D. ;
Myszka, David G. ;
Lenardo, Michael J. ;
Darnay, Bryant G. ;
Wu, Hao .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (06) :658-U97
[24]   Direct visualization of Escherichia coli chemotaxis receptor arrays using cryo-electron microscopy [J].
Zhang, Peijun ;
Khursigara, Cezar M. ;
Hartnell, Lisa M. ;
Subramaniam, Sriram .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (10) :3777-3781