Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum

被引：54

作者：

Ko, SK ^{[1
]}

Lee, SM

Whang, WK

机构：

[1] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea

[2] Ilyang Cent Res Inst, Kiheung 449900, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1999年 / 22卷 / 04期

关键词：

platelet aggregation; Rheum undulatum; cultivated Korean rhubarb rhizomes; stilbenes; desoxyrhapontigenin; rhapontigenin; piceatannol;

D O I：

10.1007/BF02979065

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

In continued studies on cultivated Korean rhubarb rhizomes (Rheum undulatum), three known stilbenes (desoxyrhapontigenin, rhapontigenin, piceatannol) have been screened for activity on blood platelet aggregation. Both rhapontigenin and desoxyrhapontigenin exhibited strong inhibition on the aggregation induced by arachidonic acid and collagen. However, piceatannol did not show inhibition. These inhibitory effects may partially contribute to anti-blood stagnancy activity of rhubarb.

引用

页码：401 / 403

页数：3

共 13 条

[1]

BORN GVR, 1963, J PHYSIOL-LONDON, V168, P178, DOI 10.1113/jphysiol.1963.sp007185

[2]

CHANDHARI M, 1983, INDIAN J CHEM, V22, P1163

[3]

DARIAS V, 1987, FARMACO, V33, P460

[4]

HARUDA R, 1983, WAKAN YAKU S, V16, P1

[5]

Ko Sung Kwon, 1998, Yakhak Hoeji, V42, P1

[6]

Kubo M., 1997, J TRAD MED, V14, P237

[7]

MIYAMOTO MASUO, 1967, YAKUGAKU ZASSHI [J PHARM SOC JAP], V87, P1040

[8]

NAMBA T, 1993, ENCY WAKAN YAKU COLO, V1, P16

[9]

Anticomplementary activity of stilbenes from medicinal plants [J].

Oh, SR ;

Ryu, SY ;

Park, SH ;

Jung, KY ;

Lee, IS ;

An, KS ;

Lee, JJ ;

Lee, HK .

ARCHIVES OF PHARMACAL RESEARCH, 1998, 21 (06) :703-706

[10]

Ryu Shi Yong, 1994, Archives of Pharmacal Research (Seoul), V17, P42, DOI 10.1007/BF02978247

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