Plaid models for gene expression data

被引：6

作者：

Lazzeroni, L

Owen, A

机构：

[1] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Biostat, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Stat, Stanford, CA 94305 USA

来源：

STATISTICA SINICA | 2002年 / 12卷 / 01期

关键词：

microarrays; SVD; transposable data; unsupervised learning;

D O I：

暂无

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

Motivated by genetic expression data, we introduce plaid models. These axe a form of two-sided cluster analysis that allows clusters to overlap. Plaid models also incorporate additive two way ANOVA models within the two-sided clusters. Using these models we find interpretable structure in some yeast expression data, as well as in some nutrition data and some foreign exchange data.

引用

收藏

页码：61 / 86

页数：26

相关论文

共 27 条

[1] Singular value decomposition for genome-wide expression data processing and modeling [J].

Alter, O ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10101-10106

[2]

[Anonymous], 1996, Clustering and Classification Ed. by, DOI DOI 10.1142/1930

[3]

ARABIE P, 1996, CLUSTERING CLASSIFIC, P6

[4] MODEL-BASED GAUSSIAN AND NON-GAUSSIAN CLUSTERING [J].

BANFIELD, JD ;

RAFTERY, AE .

BIOMETRICS, 1993, 49 (03) :803-821

[5] Clustering gene expression patterns [J].

Ben-Dor, A ;

Shamir, R ;

Yakhini, Z .

JOURNAL OF COMPUTATIONAL BIOLOGY, 1999, 6 (3-4) :281-297

[6]

Bertin J., 1983, Semiology of Graphics: Diagrams, Networks, Maps

[7] The transcriptional program of sporulation in budding yeast [J].

Chu, S ;

DeRisi, J ;

Eisen, M ;

Mulholland, J ;

Botstein, D ;

Brown, PO ;

Herskowitz, I .

SCIENCE, 1998, 282 (5389) :699-705

[8] Exploring the metabolic and genetic control of gene expression on a genomic scale [J].

DeRisi, JL ;

Iyer, VR ;

Brown, PO .

SCIENCE, 1997, 278 (5338) :680-686

[9] THE APPROXIMATION OF ONE MATRIX BY ANOTHER OF LOWER RANK [J].

Eckart, Carl ;

Young, Gale .

PSYCHOMETRIKA, 1936, 1 (03) :211-218

[10] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868