Impact of Pretransplantation 18F-fluorodeoxy Glucose-Positron Emission Tomography Status on Outcomes after Allogeneic Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma

被引：31

作者：

Bachanova, Veronika ^{[1
]}

Burns, Linda J. ^{[2
]}

Ahn, Kwang Woo ^{[3
,4
]}

Laport, Ginna G. ^{[5
]}

Akpek, Goerguen ^{[6
]}

Kharfan-Dabaja, Mohamed A. ^{[7
]}

Nishihori, Taiga ^{[7
]}

Agura, Edward ^{[8
,9
]}

Armand, Philippe ^{[10
]}

Jaglowski, Samantha M. ^{[11
]}

Cairo, Mitchell S. ^{[12
]}

Cashen, Amanda F. ^{[13
]}

Cohen, Jonathon B. ^{[14
]}

D'Souza, Anita ^{[3
]}

Freytes, Cesar O. ^{[15
,16
]}

Gale, Robert Peter ^{[17
]}

Ganguly, Siddhartha ^{[18
]}

Ghosh, Nilanjan ^{[19
]}

Holmberg, Leona A. ^{[20
]}

Inwards, David J. ^{[21
]}

Kanate, Abraham S. ^{[22
]}

Lazarus, Hillard M. ^{[23
]}

Malone, Adriana K. ^{[24
]}

Munker, Reinhold ^{[25
]}

Mussetti, Alberto ^{[26
,27
]}

Norkin, Maxim ^{[28
]}

Prestidge, Tim D. ^{[29
]}

Rowe, Jacob M. ^{[30
]}

Satwani, Prakash ^{[31
]}

Siddiqi, Tanya ^{[32
]}

Stiff, Patrick J. ^{[33
]}

William, Basem M. ^{[23
]}

Wirk, Baldeep ^{[34
]}

Maloney, David G. ^{[20
]}

Smith, Sonali M. ^{[35
]}

Sureda, Anna M. ^{[36
,37
]}

Carreras, Jeanette ^{[3
]}

Hamadani, Mehdi ^{[3
]}

机构：

[1] Univ Minnesota, Blood & Marrow Transplant Program, Med Ctr, Minneapolis, MN 55455 USA

[2] Natl Marrow Donor Program Be The Match, Hlth Serv Res, Minneapolis, MN USA

[3] Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA

[5] Stanford Hosp & Clin, Div Bone Marrow Transplant, Stanford, CA USA

[6] Banner MD Anderson Canc Ctr, Stem Cell Transplantat & Cellular Therapy Program, Gilbert, AZ USA

[7] H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA

[8] Baylor Univ, Med Ctr, Blood Serv, Dallas, TX USA

[9] Baylor Univ, Med Ctr, Marrow Transplant Serv, Dallas, TX USA

[10] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[11] Ohio State Univ, Med Ctr, Div Hematol, Columbus, OH 43210 USA

[12] New York Med Coll, Dept Pediat, Valhalla, NY 10595 USA

[13] Barnes Jewish Hosp, Dept BMT Oncol, St Louis, MO 63110 USA

[14] Emory Univ, Sch Med, Dept Hematol & Med Oncol, Winship Canc Inst, Atlanta, GA USA

[15] South Texas Vet Hlth Care Syst, San Antonio, TX USA

[16] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[17] Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Hematol Res Ctr, London, England

[18] Univ Kansas, Med Ctr, Div Hematol & Oncol, Blood & Marrow Transplantat, Kansas City, KS 66103 USA

[19] Carolinas Healthcare Syst, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA

[20] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[21] Mayo Clin, Div Hematol, Rochester, MN USA

[22] W Virginia Univ, Osborn Hematopoiet Malignancy & Transplantat Prog, Morgantown, WV 26506 USA

[23] Univ Hosp Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA

[24] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY USA

[25] Louisiana State Univ Hlth Shreveport, Dept Internal Med, Sect Hematol Oncol, Shreveport, LA USA

[26] Fdn IRCCS Inst Nazl Tumori, SC Ematol & Trapianto Midollo Osseo, Milan, Italy

[27] Univ Milan, Milan, Italy

[28] Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA

[29] Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand

[30] Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel

[31] Columbia Univ, Dept Pediat, Med Ctr, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA

[32] City Hope Natl Med Ctr, Dept Hematol Oncol, Duarte, CA 91010 USA

[33] Loyola Univ, Med Ctr, Dept Hematol Oncol, Chicago, IL 60611 USA

[34] Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA

[35] Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA

[36] Hosp Duran & Reynals, Serv Hematol, Inst Catara Oncol, Barcelona, Spain

[37] European Grp Blood & Marrow Transplantat, Istanbul, Turkey

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2015年 / 21卷 / 09期

关键词：

Non-Hodgkin lymphoma; Allogeneic transplantation; Positron emission tomography; LONG-TERM OUTCOMES; RESPONSE ASSESSMENT; PREDICT SURVIVAL; SCAN; DONOR; CHEMOTHERAPY; MALIGNANCIES; CONSENSUS; CLASSIFICATION; INDOLENT;

D O I：

10.1016/j.bbmt.2015.05.007

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Assessment with F-18-fluorodeoxy glucose (FDG) positron emission tomography (PET) before hematopoietic cell transplantation (HCT) for lymphoma may be prognostic for outcomes. Patients with chemotherapy-sensitive non-Hodgkin lymphoma (NHL) undergoing allogeneic HCT reported to the Center of International Blood and Marrow Transplantation Registry between 2007 and 2012 were included. Pre-HCT PET status (positive versus negative) was determined by the reporting transplantation centers. We analyzed 336 patients; median age was 55 years and 60% were males. Follicular lymphoma (n = 104) was more common than large cell (n = 85), mantle cell (n = 69), and mature natural killer or T cell lymphoma (n = 78); two thirds of the cohort received reduced-intensity conditioning; one half had unrelated donor grafts. Patients underwent PET scanning a median of 1 month (range, .07 to 2.83 months) before HCT; 159 were PET positive and 177 were PET negative. At 3 years, relapse/progression, progression-free survival (PFS), and overall survival (OS) in PET-positive versus PET-negative groups were 40% versus 26%; P = .007; 43% versus 47%; P = .47; and 58% versus 60%; P = .73, respectively. On multivariate analysis, a positive pretransplantation PET was associated with an increased risk of relapse/progression (risk ratio [RR], 1.86; P = .001) but was not associated with increased mortality (RR, 1.29, 95% confidence interval [CI], .96 to 1.7; P = .08), therapy failure (RR, 1.32; 95% CI, .95 to 1.84; P = .10), or nonrelapse mortality (RR, .75; 95% CI, .48 to 1.18; P = .22). PET status conferred no influence on graft-versus-host disease. A positive PET scan before HCT is associated with increased relapse risk but should not be interpreted as a barrier to a successful allograft. PET status does not appear to predict survival after allogeneic HCT for NHL. 2015 American Society for Blood and Marrow Transplantation.

引用

页码：1605 / 1611

页数：7

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