Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells

被引：7

作者：

Hazawa, Masaharu ^{[1
]}

Yasuda, Takeshi ^{[1
]}

Noshiro, Katsuko ^{[1
]}

Saotome-Nakamura, Ai ^{[1
]}

Fukuzaki, Tomoko ^{[1
]}

Michikawa, Yuichi ^{[1
]}

Gotoh, Takaya ^{[1
]}

Tajima, Katsushi ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Res Ctr Radiat Emergency Med, Inage Ku, Chiba 2638555, Japan

来源：

FEBS OPEN BIO | 2012年 / 2卷

关键词：

Vitronectin; Integrin; p21; Radiation; MAPK;

D O I：

10.1016/j.fob.2012.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Vitronectin (VN) is a multi-functional protein involved in extracellular matrix (ECM)-cell binding through integrin receptors on the cell surface, which is an important environmental process for maintaining biological homeostasis. We investigated how VN affects the survival of endothelial cells after radiation damage. VN attenuated radiation-induced expression of p21, an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK-dependent p21 induction after radiation exposure through regulation of the activity of GSK-3 beta. VN also reduced the cleavage of caspase-3, thereby inhibiting radiation-induced apoptotic cell death. These results suggest that VN has important roles in cell survival after radiation damage. (C ) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：334 / 338

页数：5

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