Engraftment and multilineage expression of human bone marrow CD34- cells in vivo

被引：36

作者：

Zanjani, ED

Almeida-Porada, G

Livingston, AG

Porada, CD

Ogawa, M

机构：

[1] Univ Nevada, Dept Vet Affairs Med Ctr, Reno, NV 89520 USA

[2] Univ S Carolina, Dept Vet Affairs Med Ctr, Charleston, SC 29401 USA

来源：

HEMATOPOIETIC STEM CELLS: BIOLOGY AND TRANSPLANTATION | 1999年 / 872卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb08467.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fetal sheep competitive engraftment model of human hematopoietic stem cells (HSC) was used to evaluate the in vivo engraftment potential of human bone marrow CD34(-) Lin(-) cells. Transplantation of CD31(-) Lin(-) cells into primary hosts resulted in the long-term (>1 gear) engraftment and multilineage donor cell/progenitor expression with production of significant numbers of CD34(+) cells. Secondary transplantation and limiting dilution studies confirmed the presence in human CD34(-) fraction of HSC with in vivo long-term engraftment and multilineage differentiation potentials.

引用

页码：220 / 232

页数：13

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