Failure of autoresuscitation in weanling mice: significance of cardiac glycogen and heart rate regulation

被引:49
作者
Deshpande, P [1 ]
Khurana, A [1 ]
Hansen, P [1 ]
Wilkins, D [1 ]
Thach, BT [1 ]
机构
[1] Univ Montpellier 2, Unite Biochim & Technol Alimentaires, Ctr Genie Biol & Sci Aliments, F-34095 Montpellier 05, France
来源
JOURNAL OF APPLIED PHYSIOLOGY | 1999年 / 13卷 / 04期
关键词
hypoxia; sudden infant death syndrome; liver; gasping; apnea;
D O I
10.1016/S0268-005X(99)00016-8
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Autoresuscitation'' (AR) is the spontaneous recovery from hypoxic apnea by gasping. We examined aspects of heart function in two situations: 1) the maturationally acquired failure of AR that is characteristic of SWR, but not BALB/c, weanling mice and 2) AR failure in BALB/c mice induced by repeated exposures to anoxia. We determined maturational changes in heart and liver glycogen. Unlike liver glycogen levels, heart glycogen levels in SWR mice differed from those in BALB/c mice. They were consistently much lower throughout maturation and reached a nadir during the brief period when SWR weanling mice are vulnerable to AR failure. Also, rate of cardiac glycogen utilization in vulnerable SWR mice was lower than that of same-aged BALB/c mice and was nil during the latter one-half of the gasping stage when heart function is critical for AR success. Therefore, because glycogen utilization reflects cardiac work, heart failure could explain AR failure in SWR weanlings. Additionally, the increase in hypoxic heart rate that occurs with maturation is developmentally delayed in SWR mice, and this may contribute to their AR failure. Cardiac glycogen was not fully depleted in BALB/c mice during repeated anoxic exposures, indicating other reasons for AR failure. We view these findings as a potential model for the age-related peak inincidence of sudden infant death syndrome. Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, St Louis, MO 63110 USA; Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA Washington University (WUSTL); Washington University (WUSTL) Thach, BT (corresponding author), Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, 1 Childrens Pl, St Louis, MO 63110 USA. 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However, the importance, origin, and significance of the mesenteric fat hypertrophy in this chronic inflammatory disease am unknown. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a crucial factor involved in the homeostasis of adipose tissue, a major source of biologically active mediators. Methods: Intraabdominal fat accumulation was quantified using a magnetic resonance imaging method in patients with Crohn's disease and controls. PPAR gamma and inflammatory cytokines synthesized by mesenteric adipose tissues were assessed by quantitative polymerase chain reaction, in situ hybridization, and immunohistochemistry. Results: In vivo, patients with Crohn's disease have an important accumulation of intra-abdominal fat. This mesenteric obesity, present from the onset of the disease, is associated with overexpression of PPAR gamma and tumor necrosis factor (TNF)-alpha, synthesized, at least in part, by adipocytes. Conclusions: These results suggest that confined increased PPAR gamma mesenteric concentrations could lead to the mesenteric fat hypertrophy, which could actively participate through the synthesis of TNF-alpha in the inflammatory response. 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JUL 1999 34 S A32 A33 2 Geochemistry & Geophysics Science Citation Index Expanded (SCI-EXPANDED) Geochemistry & Geophysics 223EA 2024-02-29 WOS:000081826400057 J Deutsch, EW Deutsch, EW The optical counterparts of the luminous X-ray binary stars in globular clusters PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF THE PACIFIC English Article Univ Washington, Dept Astron, Seattle, WA 98195 USA University of Washington; University of Washington Seattle Deutsch, EW (corresponding author), Univ Washington, Dept Astron, Box 351580, Seattle, WA 98195 USA. Deutsch, Eric/AAF-5912-2020 0 0 0 0 0 ASTRONOMICAL SOC PACIFIC SAN FRANCISCO 390 ASHTON AVE, SAN FRANCISCO, CA 94112 USA 0004-6280 PUBL ASTRON SOC PAC Publ. Astron. Soc. Pac. JUL 1999 111 761 916 916 10.1086/316392 http://dx.doi.org/10.1086/316392 1 Astronomy & Astrophysics Science Citation Index Expanded (SCI-EXPANDED) Astronomy & Astrophysics 219MW Bronze, Green Submitted 2024-02-29 WOS:000081611900017 J Dev, BN Dev, BN Materials modifications in heavy ion interactions with single crystals and their ion beam characterization NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS English Article; Proceedings Paper International Conference on Swift Heavy Ions in Materials Engineering and Characterization OCT 20-22, 1998 NUCL SCI CTR, NEW DELHI, INDIA NUCL SCI CTR BURIED COSI2 LAYERS; SHAPE TRANSITION; IMPLANTATION; INTERFACE; GROWTH; SCATTERING; SILICIDE; SURFACE; FILMS; GAAS Materials modifications in several hundred keV to a few MeV heavy ion interactions with single crystalline solids have been discussed. For the analysis of the modified layers mainly Rutherford backscattering spectrometry and channeling experiments have been performed with MeV He+, Li2+ and B2+ ions. Reviewing the recent work in the author's laboratory, examples of various kinds of modifications, such as, impurity incorporation at lattice sites, ion beam synthesis of buried epitaxial layers, modification of vaporization behavior and evolution of clusters have been presented. (C) 1999 Elsevier Science B.V. All rights reserved. Inst Phys, Bhubaneswar 751005, Orissa, India Institute of Physics Bhubaneswar (IOPB) Dev, BN (corresponding author), Inst Phys, Sachivalaya Marg, Bhubaneswar 751005, Orissa, India. bhupen@iopb.res.in CHRISTEL LA, 1981, J APPL PHYS, V52, P5050, DOI 10.1063/1.329448; Dev BN, 1998, APPL SURF SCI, V125, P163, DOI 10.1016/S0169-4332(97)00414-5; Feldman L.C., 1982, MAT ANAL ION CHANNEL; FELDMAN LC, 1982, MAT ANAL ION CHANNEL, P186; Ghose SK, 1999, NUCL INSTRUM METH B, V156, P125, DOI 10.1016/S0168-583X(99)00280-3; HASHIMOTO S, 1986, NUCL INSTRUM METH B, V13, P45, DOI 10.1016/0168-583X(86)90469-6; JEBASINSKI R, 1992, NUCL INSTRUM METH B, V64, P99, DOI 10.1016/0168-583X(92)95445-W; Kuri G, 1996, NUCL INSTRUM METH B, V111, P234, DOI 10.1016/0168-583X(95)01338-5; Kuri G, 1997, NUCL INSTRUM METH B, V129, P35, DOI 10.1016/S0168-583X(97)00125-0; Kuri G, 1996, NUCL INSTRUM METH B, V119, P403, DOI 10.1016/0168-583X(96)00360-6; LOU CY, 1971, J CHEM PHYS, V55, P4554, DOI 10.1063/1.1676789; MANTL S, 1991, MATER SCI REP, V8, P1; Satyam P. 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Atoms JUL 1999 156 1-4 258 264 10.1016/S0168-583X(99)00288-8 http://dx.doi.org/10.1016/S0168-583X(99)00288-8 7 Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S) Instruments & Instrumentation; Nuclear Science & Technology; Physics 226BG 2024-02-29 WOS:000082000000047 J Devincre, B; Veyssière, P; Saada, G Devincre, B; Veyssière, P; Saada, G Simulation of the plastic flow in Ni3Al:: work hardening and strain-rate sensitivity PHILOSOPHICAL MAGAZINE A-PHYSICS OF CONDENSED MATTER STRUCTURE DEFECTS AND MECHANICAL PROPERTIES English Article ORDERED ALLOYS; L1(2) ALLOYS; STRESS; DISLOCATIONS; TEMPERATURE; DYNAMICS; MOTION; MODEL The origin of the anomalous temperature dependence of the giant work-hardening rate and of the modest strain-rate sensitivity observed in many L1(2) alloys is investigated by means of an 'end-on' simulation of dislocation dynamics in Ni3Al. The present model reproduces most of the atypical mechanical properties observed experimentally. The study of the evolution of the distribution of the Kear-Wilsdorf locks during plastic deformation indicates that the order of magnitude of the work-hardening rate stems from a preferred exhaustion of the weakest locks. In addition, the low strain-rate sensitivity measured is found to rely on the absence of a correlation between the dislocation properties which provide the plastic strain and those which determine the flow stress level. Off Natl Etud & Rech Aerosp, CNRS, Lab Etude Microstruct, F-92322 Chatillon, France Universite Paris Saclay; National Office for Aerospace Studies & Research (ONERA); Centre National de la Recherche Scientifique (CNRS) Devincre, B (corresponding author), Off Natl Etud & Rech Aerosp, CNRS, Lab Etude Microstruct, BP 72, F-92322 Chatillon, France. 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JUL 1999 79 7 1609 1627 10.1080/01418619908210382 http://dx.doi.org/10.1080/01418619908210382 19 Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter Science Citation Index Expanded (SCI-EXPANDED) Materials Science; Metallurgy & Metallurgical Engineering; Physics 215PU 2024-02-29 WOS:000081391200007 J Devlin, JW; Boleski, G; Mlynarek, M; Nerenz, DR; Peterson, E; Jankowski, M; Horst, HM; Zarowitz, BJ Devlin, JW; Boleski, G; Mlynarek, M; Nerenz, DR; Peterson, E; Jankowski, M; Horst, HM; Zarowitz, BJ Motor Activity Assessment Scale: A valid and reliable sedation scale for use with mechanically ventilated patients in an adult surgical intensive care unit CRITICAL CARE MEDICINE English Article critical care; mechanical ventilation; sedation; psychometrics; surgery; pain; anxiety; intensive care unit; monitoring; nursing CRITICALLY ILL PATIENTS; DRUG EFFICACY; MIDAZOLAM; PROPOFOL; PAIN; NEED Objective: To establish the validity and reliability of a new sedation scale, the Motor Activity Assessment Scale (MAAS). Design:Prospective, psychometric evaluation. Setting: Sixteen-bed surgical intensive care unit (SICU) of a 937-bed tertiary care, university-affiliated teaching hospital. Patients: Twenty-five randomly selected, adult, mechanically ventilated, nonneurosurgical patients who were admitted to the SICU greater than or equal to 12 hrs after surgery and were not receiving neuromuscular blockers. Intervention: Four hundred assessments (eight per patient) were completed consecutively but independently, in pairs, at standardized times (both day and night) by two nurses who were preselected for each assessment from a pool of 32 pretrained SICU nurses. Measurements and Main Results:To estimate validity, paired assessments (four/patient) compared the MAAS result with the subjective assessment using a 10-cm visual analog sedation scale, the percent change in blood pressure and heart rate from the previous 4-hr baselines, and the number of recent agitation-related sequelae. To estimate reliability, paired assessments (four/patient) measured correlation between assessments of the same type (e.g., MAAS-MAAS). Generalized estimating equations, which accounted for the four repeated measures in each patient, supported MAAS validity by finding a linear trend between MAAS and the visual analog scale (p < .001), blood pressure (p < .001), heart rate (p < .001), and agitation-related sequelae (p < .001) end points. The MAAS (kappa = 0.83 [95% confidence interval, 0.72 to 0.94]) was found to be more reliable than subjective assessment using the visual analog scale (intraclass correlation coefficient = 0.32 [95% confidence interval, 0.05 to 0.55]). Conclusions: The MAAS is a valid and reliable sedation scale for use with mechanically ventilated patients in the SICU. Further studies are warranted regarding the effect of MAAS implementation in our SICU on patient outcomes, such as quality of sedation and length of mechanical ventilation, as well as the use of the MAAS in other patient populations (e.g., medical). Henry Ford Hosp, Dept Pharm Serv, Detroit, MI 48202 USA; Henry Ford Hosp, Patient Care Serv, Detroit, MI 48202 USA; Henry Ford Hosp, Dept Surg, Div Trauma Surg, Detroit, MI 48202 USA; Henry Ford Hlth Syst, Dept Biostat & Res Epidemiol, Detroit, MI USA; Henry Ford Hlth Syst, Dept Ambulatory Pharm Serv, Detroit, MI USA Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System; Henry Ford Hospital Devlin, JW (corresponding author), Detroit Receiving Hosp, Dept Pharm Serv, 4201 St Antoine, Detroit, MI 48201 USA. 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JUL 1999 27 7 1271 1275 10.1097/00003246-199907000-00008 http://dx.doi.org/10.1097/00003246-199907000-00008 5 Critical Care Medicine Science Citation Index Expanded (SCI-EXPANDED) General & Internal Medicine 224NZ 10446819 2024-02-29 WOS:000081906300007 J Devyatkin, VV; Runov, NN; Skorikov, VM Devyatkin, VV; Runov, NN; Skorikov, VM Synthesis of neodymium(III) germanates in solutions INORGANIC MATERIALS English Article The NdCl3-K2GeO3-L (L = H2O, C2H5OH) systems were studied by Tananaev's residual concentration method. In both systems, the equilibrium solid-phase composition depends on the initial NdCl3: K2GeO3 ratio, tt. From aqueous solutions with n less than or equal to 0.59 and n = 0.91-1.5, Nd-2(GeO3)(3) and Nd2Ge2O7 precipitate, respectively. From ethanolic solutions with n less than or equal to 0.75 and 1.61 < n less than or equal to 2.25, Nd2Ge2O7 and Nd2GeO5 precipitate, respectively. Ushinskii State Pedag Univ, Yaroslavl 150000, Russia; Russian Acad Sci, NS Kurnakov Gen & Inorgan Chem Inst, Moscow 117907, Russia Yaroslavl State Pedagogical University named after K.D. Ushinsky; Russian Academy of Sciences; Kurnakov Institute of General & Inorganic Chemistry of the Russian Academy of Sciences Devyatkin, VV (corresponding author), Ushinskii State Pedag Univ, Respublikanskaya Ul 108, Yaroslavl 150000, Russia. 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JUL 1999 35 7 716 719 4 Materials Science, Multidisciplinary Science Citation Index Expanded (SCI-EXPANDED) Materials Science 216EZ 2024-02-29 WOS:000081429600017 J Dewailly, E; Bruneau, S; Proulx, JF; Ayotte, P Dewailly, E; Bruneau, S; Proulx, JF; Ayotte, P Use of earwax as a non-invasive method to measure organochlorines in children. EPIDEMIOLOGY English Meeting Abstract Quebec Publ Hlth Ctr, Quebec City, PQ, Canada 0 1 1 1 3 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1044-3983 EPIDEMIOLOGY Epidemiology JUL 1999 10 4 268P S100 S100 1 Public, Environmental & Occupational Health Science Citation Index Expanded (SCI-EXPANDED) Public, Environmental & Occupational Health 208JK 2024-02-29 WOS:000080987100297 J Dewan, PA; Condron, SK; Morreau, PN; Byard, RW; Terlet, J Dewan, PA; Condron, SK; Morreau, PN; Byard, RW; Terlet, J Plastic migration from implanted central venous access devices ARCHIVES OF DISEASE IN CHILDHOOD English Article silicon; intravenous access device; plastic; migration SILICONE Background-This is the first reported study of histologically confirmed migration from intravenous access devices in children. Methods-The capsules from around intravenous access devices were examined by light microscopy to determine the extent of the foreign body response; energy dispersive x ray analysis was performed to document the elemental content of the foreign material. Results-A fibroconnective tissue capsule was found around all the samples. Elemental silicon was found in six of 13 tissue samples, and a foreign body giant cell reaction was seen in three of these. Conclusions-The pseudocapsule that surrounds an implanted vascular access device often has residual foreign material, including silicone. Royal Childrens Hosp, Dept Gen Surg, Parkville, Vic 3052, Australia Royal Children's Hospital Melbourne Dewan, PA (corresponding author), Royal Childrens Hosp, Dept Gen Surg, Flemington Rd, Parkville, Vic 3052, Australia. Byard, Roger/JDD-8801-2023 Byard, Roger/0000-0002-0524-5942 BOEDTS D, 1967, ARCHIV OTOLARYNGOL, V86, P562; CLAES H, 1989, J UROLOGY, V142, P821; ELLENBOGEN R, 1975, JAMA-J AM MED ASSOC, V234, P308, DOI 10.1001/jama.234.3.308; EVANS GRD, 1994, PLAST RECONSTR SURG, V93, P1117, DOI 10.1097/00006534-199405000-00001; Evans GRD, 1997, PLAST RECONSTR SURG, V99, P1354, DOI 10.1097/00006534-199704001-00023; TABATOWSKI K, 1990, ACTA CYTOL, V34, P10; TOOMEY JM, 1967, LARYNGOSCOPE, V77, P110, DOI 10.1288/00005537-196701000-00010 7 8 8 0 1 BRITISH MED JOURNAL PUBL GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0003-9888 ARCH DIS CHILD Arch. Dis. Child. JUL 1999 81 1 71 72 10.1136/adc.81.1.71 http://dx.doi.org/10.1136/adc.81.1.71 2 Pediatrics Science Citation Index Expanded (SCI-EXPANDED) Pediatrics 213QD 10373141 Bronze, Green Published 2024-02-29 WOS:000081284000017 J Dewing, J; Pritchard, E Dewing, J; Pritchard, E Views of a selected group of nurses and users on the role of Memory Clinics ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE English Meeting Abstract Royal Coll Nursing, Gerontol Nursing Programme, Oxford, England; Royal Coll Nursing, Gerontol Nursing Programme, London, England 0 0 0 0 0 DR DIETRICH STEINKOPFF VERLAG DARMSTADT PLATZ DER DEUTSCHEN EINHEIT 25, D-64293 DARMSTADT, GERMANY 0044-281X Z GERONTOL GERIATR Z. Gerontol. Geriatr. JUL 1999 32 2 2 940 245 245 1 Geriatrics & Gerontology; Gerontology Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) Geriatrics & Gerontology 217JC 2024-02-29 WOS:000081495400927 J DeWoody, KL DeWoody, KL Use of matrix designs in stability studies: A simulation study DRUG INFORMATION JOURNAL English Article drug stability study; matrix designs; uniform matrix designs; expiration dating period A stability study is designed to study the degradation profile of a drug product over time. It is required that at least three batches of the drug product in its finished form be studied over time. Often it is desired to manufacture the product in various forms, using a variety of packaging options. If three batches of product are studied for each combination of these experimental conditions at each of the recommended sampling times, the cost of the study can be substantial. Simulation studies are used to examine the effect of matrix designs; it is shown that the performance of these reduced testing plans is similar to the full sampling plan in terms of power to detect slope differences and estimation. of the expiration dating period. Centocor Inc, Dept Biostat, Malvern, PA 19355 USA; Temple Univ, Dept Stat, Philadelphia, PA 19122 USA Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University DeWoody, KL (corresponding author), Centocor Inc, Dept Biostat, 200 Great Valley Pkwy, Malvern, PA 19355 USA. DeWoody K, 1997, J Biopharm Stat, V7, P205, DOI 10.1080/10543409708835181; DEWOODY K, 1999, THESIS TEMPLE U; *FOOD DRUG ADM, 1987, GUID SUBM DOC STAB H; Murphy J R, 1996, J Biopharm Stat, V6, P477, DOI 10.1080/10543409608835157; Natarajan J., 1997, DRUG INF J, V31, P589; NORDHAUS WD, 1992, BROOKINGS PAPERS EC, V2, P1; U. S. Food and Drug Administration, 1998, FED REG, V63, P31224 7 2 2 1 1 DRUG INFORMATION ASSOCIATION FORT WASHINGTON 501 OFFICE CENTER DR, STE 450, FORT WASHINGTON, PA 19034-3212 USA 0092-8615 DRUG INF J Drug Inf. J. JUL-SEP 1999 33 3 859 868 10.1177/009286159903300327 http://dx.doi.org/10.1177/009286159903300327 10 Health Care Sciences & Services; Pharmacology & Pharmacy Science Citation Index Expanded (SCI-EXPANDED) Health Care Sciences & Services; Pharmacology & Pharmacy 228TE 2024-02-29 WOS:000082151100027 J Dhaliwal, LK; Gupta, KR; Aggarwal, N Dhaliwal, LK; Gupta, KR; Aggarwal, N Is hysterosalpingography an important tool in modern gynecological practice? INTERNATIONAL JOURNAL OF FERTILITY AND WOMENS MEDICINE English Article fertility outcome; hysterosalpingography; fallopian tube disease; laparoscopy; prognostic significance TUBAL PATHOLOGY; INFERTILITY; LAPAROSCOPY; DIAGNOSIS; ACCURACY Objective-To assess the value of hysterosalpingography (HSG) in diagnosing tubal patency and peritubal adhesions. Patients and Methods-HSG was followed whenever possible by diagnostic laparoscopy with chromopertubation to give the final prognosis in cases of infertility. Results-Normal HSG findings were obtained in 669 women, and abnormal ones in 306. No significant correlation was found between age of patient, duration, type of infertility, and HSG findings. Tubal blockage was seen in 89.2% and uterine factor in 9.4% of cases. Peritubal adhesions were suggestive in 12.75% of cases. On laparoscopy, done in about half of these women, findings were in agreement with HSG in 59.87% of cases. Follow-up was carried out whether the woman conceived, had a laparotomy, or required further investigations. Conclusion-Although somewhat insensitive, the high specificity of hysterosalpingography makes it very helpful for ruling out tubal disease, even where endoscopic evaluation is available. Postgrad Inst Med Educ & Res, Dept Obstet & Gynaecol, Chandigarh 160012, India Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh Dhaliwal, LK (corresponding author), POB 1515,PGI Post Off, Chandigarh 160012, India. DUFF DE, 1983, AM J ROENTGENOL, V141, P761; ELMINAWI MF, 1978, OBSTET GYNECOL, V51, P29; Mol BWJ, 1997, FERTIL STERIL, V67, P663, DOI 10.1016/S0015-0282(97)81363-5; Mol BWJ, 1996, HUM REPROD, V11, P1204; OPSAHL MS, 1993, FERTIL STERIL, V60, P444; RAJAH R, 1992, BRIT J RADIOL, V65, P849, DOI 10.1259/0007-1285-65-778-849; RICE JP, 1986, OBSTET GYNECOL, V67, P718, DOI 10.1097/00006250-198605000-00021; SNOWDEN EU, 1984, FERTIL STERIL, V41, P709; SWART P, 1995, FERTIL STERIL, V64, P486, DOI 10.1016/S0015-0282(16)57781-4; WADIN K, 1994, ACTA RADIOL, V35, P357 10 6 6 0 0 MEDICAL SCIENCE PUBLISHING INT INC PORT WASHINGTON 405 MAIN ST, PORT WASHINGTON, NY 11050 USA 1069-3130 INT J FERTIL WOMEN M Int. J. Fertil. Womens Med. JUL-AUG 1999 44 4 212 215 4 Obstetrics & Gynecology Science Citation Index Expanded (SCI-EXPANDED) Obstetrics & Gynecology 236EL 10499744 2024-02-29 WOS:000082585200007 J Dharmavaram, RM; Liu, G; Tuan, RS; Stokes, DG; Jiménez, SA Dharmavaram, RM; Liu, G; Tuan, RS; Stokes, DG; Jiménez, SA Stable transfection of human fetal chondrocytes with a type II procollagen minigene -: Expression of the mutant protein and alterations in the structure of the extracellular matrix in vitro ARTHRITIS AND RHEUMATISM English Article ARTICULAR-CARTILAGE DEFECTS; ACHONDROGENESIS TYPE-II; DELETED GENE; COLLAGEN; COL2A1; CHONDRODYSPLASIA; MUTATION; HYPOCHONDROGENESIS; DISEASES; VIVO Objective. To perform stable transfections of human chondrocytes under conditions that allow the maintenance of the chondrocyte-specific phenotype, and to examine the effects of the stable transfection of a mutated type II procollagen gene (COL2A1) on the structure of the cartilaginous extracellular matrix produced in vitro. Methods. A type II procollagen minigene that lacks exons 16-27 was stably transfected into human fetal epiphyseal chondrocytes in vitro, Expression of the minigene was detected by reverse transcriptase polymerase chain reaction, and the encoded protein was identified by Western blot with a human type II collagen-specific antibody. The cartilaginous extracellular matrix produced by the cultured transfected chondrocytes was characterized using histochemical staining, polarized light microscopy analysis, and transmission electron microscopy, Results. A shortened type II collagen encoded by the transfected minigene was biosynthesized and produced in the cultures of transfected cells, Histologic analyses demonstrated a more dense, negatively charged cartilaginous matrix in control cultures. In contrast, COL2A1 minigene-transfected cultures were more cellular, were populated with cells of irregular shape and less-chondrocytic appearance, contained abundant intracellular dense granules, and were sur rounded by a less-dense matrix. Polarized light microscopy and transmission electron microscopy revealed a well-organized collagen fibrillar matrix in untransfected, control chondrocyte cultures, while the matrix in the transfected cultures was less birefringent and contained numerous truncated collagen fibrils, Conclusion. The findings illustrate the feasibility of gene transfer into human fetal chondrocytes under conditions that allow the preservation of their specific phenotype, and also shed light on the function of type II collagen in the maintenance of the structural integrity of articular cartilage matrix. Thomas Jefferson Univ, Jefferson Med Coll, Div Rheumatol, Philadelphia, PA 19107 USA Jefferson University Jiménez, SA (corresponding author), Thomas Jefferson Univ, Jefferson Med Coll, Div Rheumatol, 233 S 10th St,Suite 509 BLSB, Philadelphia, PA 19107 USA. Jimenez, Sergio/0000-0001-5213-1203 NIAMS NIH HHS [AR-39740, AR-07583] Funding Source: Medline NIAMS NIH HHS(United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)) ALAKOKKO L, 1991, J BIOL CHEM, V266, P14175; Baragi VM, 1997, OSTEOARTHR CARTILAGE, V5, P275, DOI 10.1016/S1063-4584(97)80023-4; CHAN D, 1995, J BIOL CHEM, V270, P1747, DOI 10.1074/jbc.270.4.1747; EYRE DR, 1991, J CLIN INVEST, V87, P357, DOI 10.1172/JCI114994; EYRE DR, 1986, AM J HUM GENET, V39, P52; FERTALA A, 1994, BIOCHEM J, V298, P31, DOI 10.1042/bj2980031; FESCHCHENKO SP, 1989, HUM GENET, V82, P49; FREISINGER P, 1994, J BIOL CHEM, V269, P13663; GilbertBarnes E, 1996, AM J MED GENET, V63, P34, DOI 10.1002/(SICI)1096-8628(19960503)63:1<34::AID-AJMG9>3.0.CO;2-S; GODFREY M, 1988, AM J HUM GENET, V43, P904; HELMINEN HJ, 1993, J CLIN INVEST, V92, P582, DOI 10.1172/JCI116625; HORTON WA, 1987, PEDIATR RES, V22, P324, DOI 10.1203/00006450-198709000-00017; JIMENEZ S A, 1991, Arthritis and Rheumatism, V34, pS62; JIMENEZ SA, 1978, J BIOL CHEM, V253, P1420; Jimenez SA, 1997, MATRIX BIOL, V16, P29, DOI 10.1016/S0945-053X(97)90114-1; Kang R, 1997, OSTEOARTHR CARTILAGE, V5, P139, DOI 10.1016/S1063-4584(97)80007-6; MAYNE R, 1989, ARTHRITIS RHEUM, V32, P241, DOI 10.1002/anr.1780320302; PROCKOP DJ, 1995, ANNU REV BIOCHEM, V64, P403, DOI 10.1146/annurev.biochem.64.1.403; REGINATO AM, 1994, ARTHRITIS RHEUM, V37, P1338, DOI 10.1002/art.1780370912; SIERON AL, 1993, J BIOL CHEM, V268, P21232; SMALE G, 1992, ANAL BIOCHEM, V203, P352, DOI 10.1016/0003-2697(92)90324-Z; SMITH JFH, 1981, J ULTRA MOL STRUCT R, V77, P133, DOI 10.1016/S0022-5320(81)80037-8; VANDENBERG P, 1991, P NATL ACAD SCI USA, V88, P7640, DOI 10.1073/pnas.88.17.7640; VANDERREST M, 1991, FASEB J, V5, P2814, DOI 10.1096/fasebj.5.13.1916105; WILLIAMS CJ, 1995, J RHEUMATOL, V22, P28 25 18 21 0 0 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0004-3591 ARTHRITIS RHEUM Arthritis Rheum. JUL 1999 42 7 1433 1442 10.1002/1529-0131(199907)42:7<1433::AID-ANR17>3.0.CO;2-G http://dx.doi.org/10.1002/1529-0131(199907)42:7<1433::AID-ANR17>3.0.CO;2-G 10 Rheumatology Science Citation Index Expanded (SCI-EXPANDED) Rheumatology 213EK 10403271 2024-02-29 WOS:000081259400017 J Di Blasi, C; Signorelli, G; Portoricco, G Di Blasi, C; Signorelli, G; Portoricco, G Countercurrent fixed-bed gasification of biomass at laboratory scale INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH English Article FLUIDIZED-BED; FLASH PYROLYSIS; RAW GAS; STEAM A laboratory-scale countercurrent fixed-bed gasification plant has been designed and constructed to produce data for process modeling and to compare the gasification characteristics of several biomasses (beechwood, nutshells, olive husks, and grape residues). The composition of producer gas and spatial temperature profiles have been measured for biomass gasification at different air flow rates. The gas-heating value always attains a maximum as a function of this operating variable, associated with a decrease of the air-to-fuel ratio. Optimal gasification conditions of wood and agricultural residues give rise to comparable gas-heating values, comprised in the range 5-5.5 MJ/Nm(3) with 28-30% CO, 5-7% CO2, 6-8% Hz, 1-2% CH4, and small amounts of C-2- hydrocarbons (apart from nitrogen). However, gasification of agricultural residues is more difficult because of bed transport, partial ash sintering, nonuniform flow distribution, and the presence of a muddy phase in the effluents, so that proper pretreatments are needed for large-scale applications. Univ Naples Federico II, Dipartimento Ingn Chim, I-80125 Naples, Italy University of Naples Federico II Di Blasi, C (corresponding author), Univ Naples Federico II, Dipartimento Ingn Chim, P V Tecchio, I-80125 Naples, Italy. 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Eng. Chem. Res. JUL 1999 38 7 2571 2581 10.1021/ie980753i http://dx.doi.org/10.1021/ie980753i 11 Engineering, Chemical Science Citation Index Expanded (SCI-EXPANDED) Engineering 215NB 2024-02-29 WOS:000081386800007 J Di Carlo, A; Candelise, L; Gandolfo, C; Grigoletto, F; Volonnino, G; Baldereschi, M; Maggi, S; Scarlato, G; Amaducci, L; Inzitari, D Di Carlo, A; Candelise, L; Gandolfo, C; Grigoletto, F; Volonnino, G; Baldereschi, M; Maggi, S; Scarlato, G; Amaducci, L; Inzitari, D ILSA Working Grp Influence of different screening procedures on the stroke prevalence estimates: The Italian longitudinal study on aging CEREBROVASCULAR DISEASES English Article stroke; epidemiology; prevalence; screening questionnaires CEREBROVASCULAR-DISEASE; CARDIOVASCULAR-DISEASES; POPULATION; QUESTIONNAIRE; FEATURES; HEALTH Stroke prevalence surveys are more and more needed for health care and facility planning. Prevalence estimates and costs of the definition procedure may vary depending on different screening strategies, We evaluated the impact of these different strategies on the overall diagnostic procedure and on stroke prevalence estimates in the Italian Longitudinal Study on Aging. A population sample of 5,632 individuals aged 65-84 years was screened for stroke by a simple question on previous stroke diagnosis, questions on possible stroke symptoms and a simple neurological examination. Those screened positive by any of these procedures were fully examined by a neurologist for conclusive diagnosis, We determined the positive predictive value of each procedure on the final stroke diagnosis and calculated prevalence as if each procedure had been used separately, Using the three procedures combined, the prevalence rate was 6.0% (95% confidence interval, 5.4-6.7%), If each procedure had been used as the unique screening tool, the rates would have been 5.1% (4.5-5.7%), 4.1% (3.6-4.7%) and 2.3% (1.9-2.7%), a nd positive predictive values 66.4, 55.2 and 45.1%, respectively, Different screening procedures can affect stroke prevalence estimates. Compared to more complex screening strategies, the use of a simple question about previous diagnosis as the unique screening tool leads to only a slight underestimation of stroke prevalence and avoids a 66% increase in the number of subjects to be examined in a second-level specialist evaluation, potentially reducing the costs of the overall diagnostic procedure. CNR, Natl Res Council, Progetto Finalizzato Invecchiamento, Rome, Italy; Univ Milan, Ist Clin Neurol, I-20122 Milan, Italy; Univ Genoa, CNR, Dept Neurol Sci, Genoa, Italy; Univ Padua, Inst Hyg, Padua, Italy Consiglio Nazionale delle Ricerche (CNR); University of Milan; University of Genoa; Consiglio Nazionale delle Ricerche (CNR); University of Padua Inzitari, D (corresponding author), CNR, Progetto Finalizzato Invecchiamento, Via L Pancaldo 21, I-50127 Florence, Italy. dicarlo@area.fi.cnr.it Di Carlo, Antonio/AAB-9776-2022; Bortolan, Giovanni/AAY-2133-2020; Baldereschi, Marzia/AAF-9989-2019; Inzitari, Domenico/AAH-8722-2020; Scarpini, Elio/K-6547-2016 Di Carlo, Antonio/0000-0002-4822-9766; Bortolan, Giovanni/0000-0002-6603-927X; Baldereschi, Marzia/0000-0001-7703-4987; Rengo, Franco/0000-0002-2880-8357; Scarpini, Elio/0000-0002-6395-2119 AHO K, 1986, STROKE, V17, P681, DOI 10.1161/01.STR.17.4.681; BAUM HM, 1981, STROKE S1, V12, P59; BHARUCHA NE, 1988, STROKE, V19, P60, DOI 10.1161/01.STR.19.1.60; Bonita R, 1997, STROKE, V28, P1898, DOI 10.1161/01.STR.28.10.1898; Bots ML, 1996, STROKE, V27, P1499, DOI 10.1161/01.STR.27.9.1499; GUCCIONE AA, 1994, AM J PUBLIC HEALTH, V84, P351, DOI 10.2105/AJPH.84.3.351; HATANO S, 1976, B WORLD HEALTH ORGAN, V54, P541; Hoeymans N, 1998, AGE AGEING, V27, P35, DOI 10.1093/ageing/27.1.35; HU HH, 1989, STROKE, V20, P858, DOI 10.1161/01.STR.20.7.858; JAILLARD AS, 1995, STROKE, V26, P562, DOI 10.1161/01.STR.26.4.562; KISH L, 1992, WEIGHTING UNEQUAL PI, V10, P183; KURTZKE JF, 1982, NEUROLOGY, V32, P1207, DOI 10.1212/WNL.32.11.1207; LI SC, 1985, NEUROLOGY, V35, P1708, DOI 10.1212/WNL.35.12.1708; MAGGI S, 1994, AGING-CLIN EXP RES, V6, P464, DOI 10.1007/BF03324279; MITTELMARK MB, 1993, AM J EPIDEMIOL, V137, P311, DOI 10.1093/oxfordjournals.aje.a116678; MRABET A, 1990, REV NEUROL, V146, P297; OMAHONY PG, 1995, STROKE, V26, P1334, DOI 10.1161/01.STR.26.8.1334; PASCHALIS C, 1989, EUR NEUROL, V29, P186, DOI 10.1159/000116408; Psaty Bruce M., 1995, Annals of Epidemiology, V5, P270, DOI 10.1016/1047-2797(94)00092-8; Reggio A, 1996, NEUROEPIDEMIOLOGY, V15, P92, DOI 10.1159/000109894; *SAS I, 1989, SAS VERS 6 08; SCHOENBERG BS, 1986, ARCH NEUROL-CHICAGO, V43, P565, DOI 10.1001/archneur.1986.00520060029012; SORENSEN PS, 1982, ACTA NEUROL SCAND, V66, P68; URAKAMI K, 1987, STROKE, V18, P396, DOI 10.1161/01.STR.18.2.396; WYLLER TB, 1994, CEREBROVASC DIS, V4, P57, DOI 10.1159/000108452 25 11 13 0 3 KARGER BASEL ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND 1015-9770 1421-9786 CEREBROVASC DIS Cerebrovasc. Dis. JUL-AUG 1999 9 4 231 237 10.1159/000015961 http://dx.doi.org/10.1159/000015961 7 Clinical Neurology; Peripheral Vascular Disease Science Citation Index Expanded (SCI-EXPANDED) Neurosciences & Neurology; Cardiovascular System & Cardiology 212BB 10393411 2024-02-29 WOS:000081195400007 J Diamant, R; Jimenez, E; Haro-Poniatowski, E; Ponce, L; Fernandez-Guasti, M; Alonso, JC Diamant, R; Jimenez, E; Haro-Poniatowski, E; Ponce, L; Fernandez-Guasti, M; Alonso, JC Plasma dynamics inferred from optical emission spectra, during diamond-like thin film pulsed laser deposition DIAMOND AND RELATED MATERIALS English Article pulsed laser deposition; emission spectroscopy; Raman spectroscopy RAMAN Diamond-like thin films were produced via PLD with the fundamental line of a Nd:YAG laser, while the plasma dynamics were studied non-destructively by emission spectroscopy. Spectra obtained by analysing the plasma optical emission at various distances from the ablated graphite surface show how the composition and temperature vary within the plasma plume. The collected data allow the identification of various emitting species at different regions of the expanding plasma and estimation of their velocities. The further ahead in the plume, the more the ablated material is ionised. Temperatures are determined from the continuous broad background, while the plasma cools as it expands. The influence of substrate temperature on the resulting film structure is also studied through Raman scattering measurements. Optical microscope pictures are taken to evaluate surface quality. Plasma ionisation degree and kinetic energies are enough to grow diamond-like films, but high substrate temperatures favour graphitic order. (C) 1999 Elsevier Science S.A. All rights reserved. Univ Autonoma Metropolitana Iztapalapa, Dept Fis, Mexico City 09340, DF, Mexico; Univ Habana Vedado, IMRE, Habana 10400, Cuba; Univ Autonoma Metropolitana Iztapalapa, Inst Invest Mat, Mexico City 09340, DF, Mexico Universidad Autonoma Metropolitana - Mexico; Universidad de la Habana; Universidad Autonoma Metropolitana - Mexico Diamant, R (corresponding author), Univ Autonoma Metropolitana Iztapalapa, Dept Fis, Apartado Postal 55-534, Mexico City 09340, DF, Mexico. 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JUL 1999 8 7 1277 1284 10.1016/S0925-9635(99)00112-0 http://dx.doi.org/10.1016/S0925-9635(99)00112-0 8 Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter Science Citation Index Expanded (SCI-EXPANDED) Materials Science; Physics 213JL 2024-02-29 WOS:000081268900017 J Dickinson, KJM; Mark, AF Dickinson, KJM; Mark, AF Interpreting ecological patterns in an intact estuary, South-west New Zealand World Heritage Area JOURNAL OF BIOGEOGRAPHY English Article ecotourism; estuary; saltmarsh; south Westland; New Zealand; vector fitting; World Heritage Area VEGETATION ENVIRONMENT RELATIONS; ORDINATION; MARSHES; OTAGO Vegetation pattern, soil attributes, and salinity regimes along with several other environmental factors were studied in a small (11 ha) but unmodified estuary in south Westland, New Zealand. Part of an unmodified 40 km(2) catchment within the South-west New Zealand World Heritage Area, the Hapuka Estuary, formed behind a 5-km long barrier beach, provides considerable ecological value as well as baseline, conservation advocacy and educative potentials both in a national and international context. Seventy-four quadrats were sampled randomly along five transects at right angles to the main Hapuka River. Eight plant communities comprising 141 native and thirteen exotic vascular species, were differentiated using multivariate analyses, from bare mud (mean elevation 1.23 +/- 0.24 m above Mean Low Water Spring (MLWS)), saltmarsh and shrubland associations through to the adjacent podocarp-broadleaved rain forest (4.53 +/- 0.74 m above MLWS). Bulk density of the upper 10 cm of substrate varied from a maximum of 1.15 g cm(-3) in the lowest elevation association to a minimum of 0.15 g cm(-3) in the rain forest. pH showed a similar trend with values of 6.97 and 4.31, respectively. The reverse pattern was evident with organic matter, with the highest content (53% ODWt) in the rain forest substrate. The water which irrigates the saltmarsh at high tide reaches 15-19 parts per thousand salinity on calm days but may be much less saline when moderate to strong southerly winds counter the tidal influence. Northerly winds, or a southern outlet through the barrier beach, intermittently evident in the past, are likely to enhance salinity of the tidal waters across the saltmarsh. Ordination of the vegetation samples indicated a very strong gradient associated with Axis 1 (eigenvalue=0.872) and Axis 2 (eigenvalue=0.461). Vector fitting of nine measured environmental factors indicated a strong positive correlation with Axis 1 of the ordination, of soil pH, sodium and conductivity, and negative correlations with elevation, soil water, organic matter and potassium contents. Univ Otago, Dept Bot, Dunedin, New Zealand University of Otago Dickinson, KJM (corresponding author), Univ Otago, Dept Bot, POB 56, Dunedin, New Zealand. 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Biogeogr. JUL 1999 26 4 913 932 10.1111/j.1365-2699.1999.00316.x http://dx.doi.org/10.1111/j.1365-2699.1999.00316.x 20 Ecology; Geography, Physical Science Citation Index Expanded (SCI-EXPANDED) Environmental Sciences & Ecology; Physical Geography 273AV 2024-02-29 WOS:000084684400017 J Diener, J; Kovalev, D; Polisski, G; Heckler, H; Koch, F Diener, J; Kovalev, D; Polisski, G; Heckler, H; Koch, F The recombination statistics of excitons in silicon nanocrystals PHYSICA STATUS SOLIDI B-BASIC RESEARCH English Article POROUS SILICON; SI Tech Univ Munich, Phys Dept E16, D-85747 Garching, Germany Technical University of Munich Diener, J (corresponding author), Tech Univ Munich, Phys Dept E16, D-85747 Garching, Germany. 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JUL 1999 214 1 R13 R14 10.1002/(SICI)1521-3951(199907)214:1<R13::AID-PSSB999913>3.0.CO;2-# http://dx.doi.org/10.1002/(SICI)1521-3951(199907)214:1<R13::AID-PSSB999913>3.0.CO;2-# 2 Physics, Condensed Matter Science Citation Index Expanded (SCI-EXPANDED) Physics 235NF 2024-02-29 WOS:000082547300007 J Diethelm, S; Closset, A; Nisançioglu, K; Van herle, J; McEvoy, AJ; Gür, TM Diethelm, S; Closset, A; Nisançioglu, K; Van herle, J; McEvoy, AJ; Gür, TM Simultaneous determination of chemical diffusion and surface exchange coefficients of oxygen by the potential step technique JOURNAL OF THE ELECTROCHEMICAL SOCIETY English Article CONDUCTIVITY RELAXATION; TRANSPORT; SRFECO0.5OX; OXIDES Oxygen diffusion is treated in a dense electronically conducting cobaltate pellet blocked ionically on one surface, electronically on the other, and sealed on its cylindrical periphery. A procedure is developed for extracting the chemical diffusion and surface exchange coefficients for oxygen by use of the asymptotic equations derived for the current response to a potential step at short and long times. It is shown that, while the formation of interfacial phases by reaction between the sample and the electrolyte may affect the surface exchange coefficient, the chemical diffusion coefficient data determined by the present approach are independent of such interfacial phenomena. The consistency of data obtained from several specimens with varying thickness and manner of interfacing with the electrolyte validates the diffusion model and the method used for data analysis. An oxygen permeation cell is also developed in this work as a modification of the diffusion cell. The new cell allows monitoring of the permeation rate by electrochemical means. The steady-state permeation data obtained by the permeation cell are consistent with the chemical-diffusion and surface-exchange coefficients measured by the blocked diffusion cell as long as the assumptions of the related theoretical models are satisfied. This is a further validation of the diffusion model and the related methodology developed here for obtaining the necessary data for characterizing oxygen exchange and transport in such materials. (C) 1999 The Electrochemical Society. S0013-4651(98)06-048-0. All rights reserved. Ecole Polytech Fed Lausanne, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland; Stanford Univ, Ctr Mat Res, Stanford, CA 94305 USA; Norwegian Univ Sci & Technol, Dept Electrochem, N-7034 Trondheim, Norway Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Stanford University; Norwegian University of Science & Technology (NTNU) Diethelm, S (corresponding author), Ecole Polytech Fed Lausanne, Lab Photon & Interfaces, CH-1015 Lausanne, Switzerland. Diethelm, Stefan/AHD-4445-2022; Gur, Turgut M/J-8249-2012; Van herle, Jan/D-1672-2011; Nisancioglu, Kemal/AGO-4019-2022 Van herle, Jan/0000-0001-8916-6952; BELZNER A, 1992, SOLID STATE IONICS, V57, P327, DOI 10.1016/0167-2738(92)90166-M; Carslaw H. S., 1959, CONDUCTION HEAT SOLI; Crank J, 1979, MATH DIFFUSION; GESMUNDO F, 1985, OXID MET, V23, P141, DOI 10.1007/BF00659900; Guggilla S, 1997, J ELECTROCHEM SOC, V144, pL120, DOI 10.1149/1.1837631; Kilner J. 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Electrochem. Soc. JUL 1999 146 7 2606 2612 10.1149/1.1391979 http://dx.doi.org/10.1149/1.1391979 7 Electrochemistry; Materials Science, Coatings & Films Science Citation Index Expanded (SCI-EXPANDED) Electrochemistry; Materials Science 220EZ 2024-02-29 WOS:000081652700037 J Diether, S; Schaeffel, F Diether, S; Schaeffel, F Long-term changes in retinal contrast sensitivity in chicks from frosted occluders and drugs: relations to myopia? VISION RESEARCH English Article contrast adaptation; myopia; chick; retina FORM-DEPRIVATION MYOPIA; EYE GROWTH; PATTERN ELECTRORETINOGRAM; CHROMATIC ABERRATION; 6-HYDROXY DOPAMINE; VISUAL EXPERIENCE; REFRACTIVE ERRORS; SPECTACLE LENSES; NERVE-SECTION; ACCOMMODATION Experiments in animal models have shown that the retina analyzes the image to identify the position of the plane of focus and fine-tunes the growth of the underlying sclera. It is fundamental to the understanding of the development of refractive errors to know which image features are processed. Since the position of the image plane fluctuates continuously with accommodative status and viewing distance, a meaningful control of refractive development can only occur by an averaging procedure with a long time constant. As a candidate for a retinal signal for enhanced eye growth and myopia we propose the level of contrast adaptation which varies with the average amount of defocus. Using a behavioural paradigm, we have found in chickens (1) that contrast adaptation (CA, here referred to as an increase in contrast sensitivity) occurs at low spatial frequencies (0.2 cyc/deg) already after 1.5 h of wearing frosted goggles which cause deprivation myopia, (2) that CA also occurs with negative lenses (- 7.4D) and positive lenses (+ 6.9D) after 1.5 h, at least if accommodation is paralyzed and, (3) that CA occurs at a retinal level or has, at least, a retinal component. Furthermore, we have studied the effects of atropine and reserpine, which both suppress myopia development, on CA. Quisqualate, which causes retinal degeneration but leaves emmetropization functional, was also tested. We found that both atropine and reserpine increase contrast sensitivity to a level where no further CA could be induced by frosted goggles. Quisqualate increased only the variability of refractive development and of contrast sensitivity. Taken together, CA occurring during extended periods of defocus is a possible candidate for a retinal error signal for myopia development. However, the situation is complicated by the fact that there must be a second image processing mode generating a powerful inhibitory growth signal if the image is in front of the retina, even with poor images (Diether, S., & Schaeffel, F. (1999). Vision Research, 39, 1585-1589). (C) 1999 Elsevier Science Ltd. All rights reserved. Univ Tubingen, Hosp Eye, Dept Expt Ophthalmol, D-72076 Tubingen, Germany Eberhard Karls University of Tubingen Schaeffel, F (corresponding author), Univ Tubingen, Hosp Eye, Dept Expt Ophthalmol, Rontgenweg 11, D-72076 Tubingen, Germany. frank.schaeffel@uni-tuebingen.de BARTMANN M, 1994, VISION RES, V34, P873, DOI 10.1016/0042-6989(94)90037-X; BELL GA, 1977, BRAIN RES, V124, P263, DOI 10.1016/0006-8993(77)90884-8; Bodis-Wollner I, 1998, VISION RES, V38, P1479, DOI 10.1016/S0042-6989(98)00028-5; BRIGELL MG, 1987, INVEST OPHTH VIS SCI, V28, P1614; Diether S, 1997, VISION RES, V37, P659, DOI 10.1016/S0042-6989(96)00224-6; Diether Sigrid, 1997, Investigative Ophthalmology and Visual Science, V38, pS542; Fischer AJ, 1998, J COMP NEUROL, V393, P1; GEORGESON MA, 1975, J PHYSIOL-LONDON, V252, P627, DOI 10.1113/jphysiol.1975.sp011162; Goss DA, 1996, OPTOMETRY VISION SCI, V73, P263, DOI 10.1097/00006324-199604000-00008; GOSS DA, 1991, OPTOMETRY VISION SCI, V68, P110, DOI 10.1097/00006324-199102000-00005; GREENLEE MW, 1991, VISION RES, V31, P223, DOI 10.1016/0042-6989(91)90113-J; Kaymak Hakan, 1997, Investigative Ophthalmology and Visual Science, V38, pS758; Kee Chea-Su, 1998, IOVS, V39, pS715; KRUGER PB, 1995, OPTOMETRY VISION SCI, V72, P656, DOI 10.1097/00006324-199509000-00009; MCBRIEN NA, 1993, INVEST OPHTH VIS SCI, V34, P205; NAPPER GA, 1995, VISION RES, V35, P1337, DOI 10.1016/0042-6989(94)00226-C; Nau A., 1998, IOVS, V39, pS715; NICKLA D L, 1989, Investigative Ophthalmology and Visual Science, V30, P31; ODOM JV, 1984, DOC OPHTHALMOL P SER, V40, P29; Ohngemach S, 1997, VISUAL NEUROSCI, V14, P493, DOI 10.1017/S0952523800012153; ROHRER B, 1993, VISUAL NEUROSCI, V10, P447, DOI 10.1017/S0952523800004673; SCHAEFFEL F, 1990, VISUAL NEUROSCI, V4, P177, DOI 10.1017/S0952523800002327; Schaeffel F, 1999, OPHTHAL PHYSL OPT, V19, P180, DOI 10.1046/j.1475-1313.1999.00430.x; SCHAEFFEL F, 1988, VISION RES, V28, P639, DOI 10.1016/0042-6989(88)90113-7; SCHAEFFEL F, 1994, J OPT SOC AM A, V11, P487, DOI 10.1364/JOSAA.11.000487; Schaeffel F, 1999, VISION RES, V39, P1585, DOI 10.1016/S0042-6989(98)00304-6; SCHAEFFEL F, 1994, VISION RES, V34, P143, DOI 10.1016/0042-6989(94)90327-1; SCHAEFFEL F, 1995, VISION RES, V35, P1247, DOI 10.1016/0042-6989(94)00221-7; SCHAEFFEL F, 1991, VISION RES, V31, P717, DOI 10.1016/0042-6989(91)90011-S; SCHAEFFEL F, 1998, P 6 INT C MYOP TOK, P255; Schmid KL, 1997, VISION RES, V37, P2011, DOI 10.1016/S0042-6989(97)00014-X; Schmid KL, 1996, VISION RES, V36, P1023, DOI 10.1016/0042-6989(95)00191-3; Schmid KL, 1997, OPTOMETRY VISION SCI, V74, P20, DOI 10.1097/00006324-199701000-00016; Schmid KL, 1997, OPHTHAL PHYSL OPT, V17, P61, DOI 10.1111/j.1475-1313.1997.tb00525.x; Schwahn HN, 1997, VISION RES, V37, P2661, DOI 10.1016/S0042-6989(97)00114-4; SCHWAHN HN, 1994, INVEST OPHTH VIS SCI, V35, P3516; Siegwart J. 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JUL 1999 39 15 2499 2510 10.1016/S0042-6989(99)00005-X http://dx.doi.org/10.1016/S0042-6989(99)00005-X 12 Neurosciences; Ophthalmology; Psychology Science Citation Index Expanded (SCI-EXPANDED) Neurosciences & Neurology; Ophthalmology; Psychology 192XN 10396619 hybrid 2024-02-29 WOS:000080105200007 J Díez, JJ; Iglesias, P; Aguilera, A; Bajo, MA; Selgas, R Díez, JJ; Iglesias, P; Aguilera, A; Bajo, MA; Selgas, R Effects of cholinergic muscarinic blockade on growth hormone responses to growth hormone-releasing hormone in uraemic patients NEPHROLOGY DIALYSIS TRANSPLANTATION English Article chronic renal failure; growth hormone; growth hormone-releasing hormone; peritoneal dialysis; pirenzepine CHRONIC RENAL-FAILURE; INDUCED GH SECRETION; RECOMBINANT-HUMAN-ERYTHROPOIETIN; CHRONIC-HEMODIALYSIS; SOMATOSTATINERGIC TONE; RECEPTOR BLOCKADE; ANOREXIA-NERVOSA; NORMAL MEN; PYRIDOSTIGMINE; INSULIN Background. Several alterations in growth hormone (GH) secretion have been reported in patients with chronic renal insufficiency. However, cholinergic modulation of somatotopic cell function has not been fully clarified in uraemic patients. To gain further insight into the disrupted mechanism of GH regulation in chronic renal failure, we investigated whether the blockade of cholinergic muscarinic receptor with pirenzepine could modify the response of GH to its physiological releasing hormone. Methods. Eight uraemic male patients on peritoneal dialysis and six normal controls were studied. All subjects underwent two endocrine tests in random order. In one of them placebo was administered 60 min before the injection of GH-releasing hormone (GHRH, 100 mu g, i.v. in bolus at 0 min). In another the muscarinic blocking agent pirenzepine, 100 mg p.o., was administered at that time. Blood samples for GH were collected at -60, 0, 15, 30, 45, 60 and 90 min. Results. Baseline plasma GH concentrations were similar in patients and controls. GH responses to GHRH were characterized by great interindividual variability in uraemic patients with regard to the amount and the time to maximal peak. In the placebo plus GHRH test, the maximum GH concentrations in patients (14.0+/-3.2 mu g/l) were similar to those reached by controls (18.0+/-3.1 mu g/l), although GH secretion was more sustained in patients. The area under the secretory curve (AUC) of GH secretion in patients was also similar to that found in controls (14.4+/-2.9 vs 15.4+/-3.3 mu g/h/l). When subjects were given pirenzepine before GHRH injection an abolishment of GHRH-induced GH release was observed in all controls and in all but one of the uraemic patients. The AUC of GH secretion was, therefore, significantly reduced both in uraemic patients (4.1+/-2.0 mu g/h/l, P<0.05) and in control subjects (2.0+/-0.3 mu g/h/l, P<0.05). Conclusion. These results suggest that GH secretion in uraemic patients is modulated, at least in part, by a cholinergic mechanism. The muscarinic blockade, possibly acting via an increase in somatosatin release, is able to inhibit GH release in response to direct pituitary stimulation with GHRH. Hosp La Paz, Dept Endocrinol, Madrid, Spain; Hosp La Paz, Dept Nephrol, Madrid, Spain Hospital Universitario La Paz; Hospital Universitario La Paz Travesia Tellez 8,4R, E-28007 Madrid, Spain. mibarsd@infomed-dental.com Bajo, Maria A/ABF-6991-2020; Iglesias, P/AAU-1011-2020; Diez, Juan J./W-1803-2017; Iglesias, Pedro/AAC-1016-2020 Bajo, Maria A/0000-0001-7364-557X; Iglesias, P/0000-0003-0126-1985; Diez, Juan J./0000-0002-2017-0694; Iglesias, Pedro/0000-0003-0126-1985 Aman J, 1996, ACTA PAEDIATR, V85, P31, DOI 10.1111/j.1651-2227.1996.tb13886.x; ARENDS J, 1988, J CLIN ENDOCR METAB, V66, P389, DOI 10.1210/jcem-66-2-389; ARVAT E, 1993, J CLIN ENDOCR METAB, V76, P374, DOI 10.1210/jc.76.2.374; BESSARIONE D, 1987, ACTA ENDOCRINOL-COP, V114, P5, DOI 10.1530/acta.0.1140005; CANTALAMESSA L, 1991, CLIN ENDOCRINOL, V34, P85, DOI 10.1111/j.1365-2265.1991.tb01740.x; CAPPA M, 1991, PEDIATR NEPHROL, V5, P548, DOI 10.1007/BF01453699; CASANUEVA FF, 1983, ACTA ENDOCRINOL-COP, V103, P15, DOI 10.1530/acta.0.1030015; CASANUEVA FF, 1986, J CLIN ENDOCR METAB, V62, P186, DOI 10.1210/jcem-62-1-186; DELITALA G, 1983, J CLIN ENDOCR METAB, V57, P1145, DOI 10.1210/jcem-57-6-1145; DELITALA G, 1982, J CLIN ENDOCR METAB, V55, P1231, DOI 10.1210/jcem-55-6-1231; DELITALA G, 1987, NEUROENDOCRINOLOGY, V45, P243, DOI 10.1159/000124732; DIEGUEZ C, 1988, CLIN ENDOCRINOL, V28, P109; Diez JJ, 1996, NEPHRON, V74, P548, DOI 10.1159/000189450; DIEZ JJ, 1993, MED CLIN-BARCELONA, V100, P547; Friend K, 1997, EUR J ENDOCRINOL, V137, P377, DOI 10.1530/eje.0.1370377; Goni MJ, 1997, METABOLISM, V46, P1305, DOI 10.1016/S0026-0495(97)90235-3; GONZALEZ.D, 1973, J CLIN ENDOCR METAB, V36, P117, DOI 10.1210/jcem-36-1-117; ISMAIL IS, 1993, CLIN ENDOCRINOL, V38, P149, DOI 10.1111/j.1365-2265.1993.tb00987.x; KELIJMAN M, 1991, J CLIN ENDOCR METAB, V72, P1081; LACOUR B, 1986, NEPHRON, V44, P235, DOI 10.1159/000183993; LIM VS, 1978, MED CLIN N AM, V62, P1341; LOCATELLI V, 1986, J ENDOCRINOL, V111, P271, DOI 10.1677/joe.0.1110271; MAHESHWARI HG, 1992, ACTA ENDOCRINOL-COP, V127, P485, DOI 10.1530/acta.0.1270485; MARUMO F, 1979, NEPHRON, V24, P81, DOI 10.1159/000181688; MASSARA F, 1986, NEUROENDOCRINOLOGY, V43, P670, DOI 10.1159/000124602; MASSARA F, 1986, ACTA ENDOCRINOL-COP, V113, P12, DOI 10.1530/acta.0.1130012; MASSARA F, 1984, J CLIN ENDOCR METAB, V59, P1025, DOI 10.1210/jcem-59-5-1025; MURIALDO G, 1991, NEUROPSYCHOBIOLOGY, V24, P129, DOI 10.1159/000119475; PENALVA A, 1990, J CLIN ENDOCR METAB, V70, P324, DOI 10.1210/jcem-70-2-324; PENALVA A, 1993, J CLIN ENDOCR METAB, V76, P168, DOI 10.1210/jc.76.1.168; RAMIREZ G, 1990, METABOLISM, V39, P764, DOI 10.1016/0026-0495(90)90114-R; RAMIREZ G, 1994, J CLIN ENDOCR METAB, V78, P63, DOI 10.1210/jc.78.1.63; RAMIREZ G, 1978, ARCH INTERN MED, V138, P267, DOI 10.1001/archinte.138.2.267; RICHARDSON SB, 1980, ENDOCRINOLOGY, V107, P122, DOI 10.1210/endo-107-1-122; RODGER RSC, 1986, NEPHRON, V43, P169, DOI 10.1159/000183824; ROLLA M, 1991, BIOL PSYCHIAT, V29, P1079, DOI 10.1016/0006-3223(91)90250-P; SAMAAN NA, 1970, METABOLIS, V19, P102, DOI 10.1016/S0026-0495(70)90171-X; SANTOS F, 1991, CHILD NEPHROL UROL, V11, P130; TAMAI H, 1990, J CLIN ENDOCR METAB, V70, P738, DOI 10.1210/jcem-70-3-738; TORSELLO A, 1988, J ENDOCRINOL, V117, P273, DOI 10.1677/joe.0.1170273; VALCAVI R, 1991, CLIN ENDOCRINOL, V35, P141, DOI 10.1111/j.1365-2265.1991.tb03512.x; VELDHUIS JD, 1994, EUR J ENDOCRINOL, V131, P489, DOI 10.1530/eje.0.1310489; WATSCHINGER B, 1991, HORM RES, V36, P22, DOI 10.1159/000182100; WEHRENBERG WB, 1992, ENDOCRINOLOGY, V130, P1445, DOI 10.1210/en.130.3.1445 44 1 1 0 2 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0931-0509 1460-2385 NEPHROL DIAL TRANSPL Nephrol. Dial. Transplant. JUL 1999 14 7 1704 1709 10.1093/ndt/14.7.1704 http://dx.doi.org/10.1093/ndt/14.7.1704 6 Transplantation; Urology & Nephrology Science Citation Index Expanded (SCI-EXPANDED) Transplantation; Urology & Nephrology 217GG 10435880 Bronze 2024-02-29 WOS:000081491200017 J Digrak, M; Alma, MH; Ilçim, A; Sen, S Digrak, M; Alma, MH; Ilçim, A; Sen, S Antibacterial and antifungal effects of various commercial plant extracts PHARMACEUTICAL BIOLOGY English Article antimicrobial activity; gallnut powders; mimosa bark; Phlomis bourgei; Salvia aucheri var aucheri; valex The antimicrobial activities of valex (the extract of valonia), the extracts of mimosa bark, gallnut powders, Salvia aucheri Bentham var aucheri and Phlomis bourgei Boiss were studied. The antimicrobial activity of the above plants was evaluated by the disk diffusion method using Bacillus brevis TMC 3, Bacillus subtilis IMG 22, Bacillus cereus EU, Escherichia coli DM, Pseudomanas aeruginosa DSM 50071, Staphylococcus aureus Cowan 1, Listeria monocytogenes A. Micrococcus luteus LA 2971, Klebsiella pneumoniae FMC 5, Mycobacterium smegmatus RUT, Proteus vulgaris FMC 1 bacteria, and Alternaria alternata MDC 97 Penicillium italicum MDC 101, Fusarium equiseti C, Candida albicans CCM 314 fungi. The results indicated that mimosa bark extracts had the greatest antibacterial activity, followed by the valex, gallnut powders, Salvia aucheri var. aucheri and Phlomis bourgei extracts, respectively. Furthermore, it was found that gallnut powders and the extracts of mimosa bark contained high amounts of tannins and showed antifungal activity. Kahramanmaras Sutc Imam Univ, Fac Arts & Sci, Dept Biol, TR-46045 Kahramanmaras, Turkey; Kahramanmaras Sutc Imam Univ, Dept Ind Engn & Forestry, TR-46045 Kahramanmaras, Turkey Kahramanmaras Sutcu Imam University; Kahramanmaras Sutcu Imam University Digrak, M (corresponding author), Kahramanmaras Sutc Imam Univ, Fac Arts & Sci, Dept Biol, TR-46045 Kahramanmaras, Turkey. 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JUL 1999 37 3 216 220 10.1076/phbi.37.3.216.6307 http://dx.doi.org/10.1076/phbi.37.3.216.6307 5 Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy Science Citation Index Expanded (SCI-EXPANDED) Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy 247XN Bronze 2024-02-29 WOS:000083246400007 J DiGregorio, LM; Krasny, ME; Fahey, TJ DiGregorio, LM; Krasny, ME; Fahey, TJ Radial growth trends of sugar maple (Acer saccharum) in an Allegheny northern hardwood forest affected by beech bark disease JOURNAL OF THE TORREY BOTANICAL SOCIETY English Article Acer saccharum; radial growth; Allegheny northern hardwoods; gap; beech bark disease CANOPY GAPS; FAGUS-GRANDIFOLIA; TROPICAL FORESTS; CRAWFORD-NOTCH; TREEFALL GAPS; NEW-HAMPSHIRE; SUB-ALPINE; PATTERNS; DISTURBANCE; DYNAMICS In many forests of the northeastern U.S., canopy gaps are the predominant mode of disturbance and thus regulate future forest structure and species composition. We examined radial growth trends in canopy and subcanopy sugar maple (Acer saccharum Marsh.) trees growing in gaps and non-gap areas in three second-growth, Allegheny northern hardwood forest stands in central New York. Our objective was to determine if a recent diffuse disturbance of the canopy caused by beech bark disease stimulated growth of sugar maple trees in gaps and throughout the forest. Annual radial growth (mm/yr) of canopy gap-edge trees and subcanopy trees in gaps was significantly greater than that of canopy trees and subcanopy trees in non-gap areas. During the period of beech bark disease-induced canopy decline, non-gap subcanopy trees exhibited an annual radial growth 30% higher and a radial growth rate (mm/yr/yr) four times greater than during the years prior to the disturbance. In contrast, canopy trees not adjacent to gaps showed no change in radial growth coincident with the disturbance. These results suggest that in forests with significant canopy deterioration, differences in tree growth between gap and nongap environments can be expected; however, positive growth responses among sub-canopy trees may not be limited to the area directly in gaps and instead may occur throughout the forest. Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA Cornell University DiGregorio, LM (corresponding author), Cornell Univ, Dept Nat Resources, Fernow Hall, Ithaca, NY 14853 USA. 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JUL-SEP 1999 126 3 245 254 10.2307/2997279 http://dx.doi.org/10.2307/2997279 10 Plant Sciences Science Citation Index Expanded (SCI-EXPANDED) Plant Sciences 220LJ 2024-02-29 WOS:000081667200007 J Dimond, PF Dimond, PF Peptide synthesis technologies - Number of firms offer large-scale strategies and techniques GENETIC ENGINEERING NEWS English Article 0 0 0 0 0 MARY ANN LIEBERT INC PUBL LARCHMONT 2 MADISON AVENUE, LARCHMONT, NY 10538 USA 0270-6377 GENET ENG NEWS Genet. Eng. News JUL 1999 19 13 15 + 0 Biotechnology & Applied Microbiology; Genetics & Heredity Science Citation Index Expanded (SCI-EXPANDED) Biotechnology & Applied Microbiology; Genetics & Heredity 220AU 2024-02-29 WOS:000081642500007 J Ding, DY; Xie, HS; Su, GL; Guo, J; Jiang, DY; Xu, ZM; Zhang, YM Ding, DY; Xie, HS; Su, GL; Guo, J; Jiang, DY; Xu, ZM; Zhang, YM SiO2 glasses synthesized at 355-445°C and 2.0-5.5 GPa CHINESE SCIENCE BULLETIN English Article synthesized at high pressure; SiO2 glass; refraction index; water EXPERIMENTAL CONSTRAINTS; ZONE A series of SiO2 glasses were: synthesized by using spectroscopically pure silica on the YJ-3000 multi-anvil apparatus at 355-445 degrees C and 2.0-5.5 GPa. Their spectroscopic characteristics resemble that of the high-density quartz glass. In the meantime, the IR spectra of SiO2 glasses show that a small amount of water exists in SiO2 glasses in the form of OH-. It may be due simply to the small amount of water that contributes significantly to the amorphism of SiO2. The determination of refraction indices of SiO2 glasses shows that the refraction indices of SiO2 glasses and the high-density quartz glass are in good logarithmic relation with synthetic pressures. Chinese Acad Sci, Inst Geochem, Guiyang 550002, Peoples R China Chinese Academy of Sciences; Guiyang Institute of Geochemistry, CAS Ding, DY (corresponding author), Chinese Acad Sci, Inst Geochem, Guiyang 550002, Peoples R China. 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JUL 1999 44 13 1229 1232 10.1007/BF02885972 http://dx.doi.org/10.1007/BF02885972 4 Multidisciplinary Sciences Science Citation Index Expanded (SCI-EXPANDED) Science & Technology - Other Topics 242RG 2024-02-29 WOS:000082955000017 J Ding, H; Lamb, RJ Ding, H; Lamb, RJ Oviposition and larval establishment of Sitodiplosis mosellana (Diptera: Cecidomyiidae) on wheat (Gramineae) at different growth stages CANADIAN ENTOMOLOGIST English Article GEHIN DIPTERA; SPRING WHEAT; MIDGE; SASKATCHEWAN; INFESTATION; CEREALS The wheat midge, Sitodiplosis mosellana (Gehin), infests wheat, Triticum aestivum L., heads only up to anthesis when pollination occurs. The termination of infestation might be due to a deterrence of oviposition or to a suppression of larval growth on developing seeds. These hypotheses were tested in the laboratory by measuring oviposition preference, larval development, and larval preference for plants at different growth stages. Females showed no preference for ovipositing on heads at any stage from the onset of heading up to and including anthesis, and continued to lay eggs at a reduced rate 10 days after anthesis. Survival of newly hatched larvae was reduced on seeds 3-4 days after anthesis and survival and development was greatly reduced on seeds 5 or 6 days after anthesis. Larvae moved away from older seeds and fed on younger seeds in a choice test. Given a hatching time of 5-6 days, a failure to infest wheat after anthesis is not due to oviposition deterrence at anthesis, but to suppression of larval growth and development which begins soon after anthesis. Agr & Agri Food Canada, Cereal Res Ctr, Winnipeg, MB R3T 2M9, Canada Agriculture & Agri Food Canada Lamb, RJ (corresponding author), Agr & Agri Food Canada, Cereal Res Ctr, 195 Dafoe Rd, Winnipeg, MB R3T 2M9, Canada. 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JUL-AUG 1999 131 4 475 481 10.4039/Ent131475-4 http://dx.doi.org/10.4039/Ent131475-4 7 Entomology Science Citation Index Expanded (SCI-EXPANDED) Entomology 218ME 2024-02-29 WOS:000081555700007 J Ding, JT Ding, JT A remark on the FRTS realization and Drinfeld realization of quantum affine superalgebra Uq(osp(1, 2)) LETTERS IN MATHEMATICAL PHYSICS English Article quantum affine superalgebra; the q-Serre relation In this Letter, we present the hidden symmetry behind the Faddeev-Reshetikhin-Takhtajan-Semenov-Tian-Shansky (FRTS) realization of quantum affine superalgebras U-q(o (s) over cap p(1,2)) and add the q-Serre relation to the Drinfeld realization of U-q(o (s) over cap p(1,2)), derived from the FRTS realization. Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA University System of Ohio; University of Cincinnati Ding, JT (corresponding author), Univ Cincinnati, Dept Math Sci, 2624 Clifton Ave, Cincinnati, OH 45221 USA. 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JUL 1999 49 2 161 171 10.1023/A:1007645107236 http://dx.doi.org/10.1023/A:1007645107236 11 Physics, Mathematical Science Citation Index Expanded (SCI-EXPANDED) Physics 256GG 2024-02-29 WOS:000083717100007 J Dinnyés, A; Lonergan, P; Fair, T; Boland, MP; Yang, XZ Dinnyés, A; Lonergan, P; Fair, T; Boland, MP; Yang, XZ Timing of the first cleavage post-insemination affects cryosurvival of in vitro-produced bovine blastocysts MOLECULAR REPRODUCTION AND DEVELOPMENT English Article in vitro; cattle; embryo; vitrification; SOF SYNTHETIC OVIDUCT FLUID; HIGH IN-VITRO; OOCYTE MATURATION; EMBRYO CRYOPRESERVATION; FERTILIZED INVITRO; PREGNANCY RATES; 1ST CLEAVAGE; SURVIVAL; FROZEN; VITRIFICATION The time of the first cleavage of bovine zygotes during in vitro culture can affect the rate of development and cell number of the blastocysts. The aim of this work was to study the effect of the timing of first cleavage on the cryosurvival of the resulting blastocysts, Following standard IVM and IVF, zygotes were cultured in modified synthetic oviduct fluid (SOF), with 10% fetal calf serum (FCS) added 48 hr post insemination, in a humidified atmosphere of 5% CO2, 5% O-2 and 90% N-2, Embryos which cleaved by 24, 27 30, 33, or 36 hr after insemination (IVF) were harvested and further cultured to the blastocyst stage (day 7 or day 8 post IVF), All developing blastocysts on days 7 and 8 were classified into three groups and were cryopreserved by vitrification. Group A consisted of blastocysts (<150 mu m, small blastocysts); group B consisted of expanded or hatching blastocysts (>150 mu m, large blastocysts); and group C consisted of morphologically poor quality blastocysts. The vitrification solution consisted of 6.5 M glycerol and 6% bovine serum albumin in PBS (VS3a). Thawed embryos were cultured further and survival was defined as the re-expansion and maintenance of the blastocoel over 24, 48, and 72 hr, respectively. Overall survival and hatching at 72 hr post-thawing was higher in blastocysts formed by day 7 than those formed by day 8 (60% vs, 40% survival; 63% vs. 45% hatching). Large blastocysts from day-7 and day-8 groups survived significantly better than small or poor quality blastocysts (76% vs. 63% and 31%; 72% vs. 30% and 26%, respectively; P < 0.05). Day-7 blastocysts from the 27- and 30-hr cleavage groups survived significantly better than those from the 36-hr group (63% and 66% vs. 25%, P < 0.05). Day-8 blastocysts from later cleaved (30 hr) zygotes had a higher survival than the 27-hr cleavage groups (52% vs. 26%, P < 0.05). These results indicate that the day of blastocyst appearance, developmental stage, and timing of the first cleavage post-insemination can influence the cryosurvival of bovine blastocysts following vitrification. 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Reprod. Dev. JUL 1999 53 3 318 324 10.1002/(SICI)1098-2795(199907)53:3<318::AID-MRD7>3.3.CO;2-F http://dx.doi.org/10.1002/(SICI)1098-2795(199907)53:3<318::AID-MRD7>3.3.CO;2-F 7 Biochemistry & Molecular Biology; Cell Biology; Developmental Biology; Reproductive Biology Science Citation Index Expanded (SCI-EXPANDED) Biochemistry & Molecular Biology; Cell Biology; Developmental Biology; Reproductive Biology 199LX 10369392 2024-02-29 WOS:000080484500007 J Dirik, K; Göncüoglu, MC; Kozlu, H Dirik, K; Göncüoglu, MC; Kozlu, H Stratigraphy and pre-Miocene tectonic evolution of the southwestern part of the Sivas Basin, Central Anatolia, Turkey GEOLOGICAL JOURNAL English Article Sivas Basin; intracontinental basin; within-continental-plate eruptive setting; transpression; transtension BLOCK In central Anatolia there are several important basins developed mainly after closure of the northern branch of Neotethys. These are the Haymana, Tuzgolu, Ulukisla, Kizihrmak, Cankiri-Corum and Sivas basins. The Sivas Basin is located in the eastern part of central Anatolia between the Central Anatolian Crystalline Complex (CACC) in the north and Taurides in the south. The basement to the southeastern part of the basin consists of recrystallized limestone and clastics of the Permian-Lower Cretaceous Bunyan Metamorphics. These units are overlain by an Upper Cretaceous ophiolitic olistostrome that is overthrust by ophiolites and high pressure-low temperature metamorphic rocks. Lower Palaeocene cover units unconformably overlie this sequence. The basement to the northwestern part is constituted by CACC that includes a high temperature-low pressure polymetamorphic succession of Palaeozoic-Mesozoic age, overthrust by ophiolites and intruded by Upper Cretaceous post-collisional granitoids and syenitoids. The uppermost Maastrichtian-Palaeocene continental to shallow marine (lagoonal) unit unconformably overlies this unit. 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JUL 1999 32 2 2 313 82 82 1 Geriatrics & Gerontology; Gerontology Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) Geriatrics & Gerontology 217JC 2024-02-29 WOS:000081495400307 J Dittrich, S; Vogel, M; Dähnert, I; Berger, F; Alexi-Meskishvili, V; Lange, PE Dittrich, S; Vogel, M; Dähnert, I; Berger, F; Alexi-Meskishvili, V; Lange, PE Surgical repair of tetralogy of Fallot in adults today CLINICAL CARDIOLOGY English Article adult tetralogy of Fallot; late repair; arrhythmias; follow-up; socioeconomic status in congenital heart disease TERM FOLLOW-UP; VENTRICULAR ARRHYTHMIA; SURVIVAL; SURGERY; OUTFLOW; OLDER; AGE Background: Today, corrective surgery of native tetralogy of Fallot beyond childhood is a rare exception. In the years following the fall of the Berlin wall, 22 adults with uncorrected tetralogy presented to our center, mostly from former Eastern Block countries. Hypothesis: Our aim was to examine whether adults with tetralogy of Fallot benefit from late surgical repair. Nineteen patients underwent corrective surgery; hospital mortality was 16%. Follow-up examination 3.5 (0.3-9.7) years postoperatively consisted of chart review and a written questionnaire. Incidence of ventricular arrhythmias was 32% before surgery and increased to 50% 3.5 years after surgery. Clinical status and New York Heart Association classification were clearly improved. This was not reflected in an improvement of the patients' socioeconomic status, as none of the 9 patients in our group of 19, who were jobless before the surgery, experienced a change in employment status. Marital status did not change in any patient and, in particular, the number of single male patients remains high. Except for one nearly asymptomatic younger woman who had delivered four children, only one of the seven married women had delivered a child before and one of the younger women after cardiac repair, which we consider to be a positive effect of this surgery. Surgical correction of adult patients with tetralogy of Fallot carries a higher risk compared with correction in childhood. It improves quality of Life but does not change socioeconomic habits. Deutsch Herzzentrum Berlin, Abt Angeborene Herzfehler, Dept Congenital Heart Dis, D-13353 Berlin, Germany; German Heart Ctr, Dept Cardiac Thorac & Arterial Surg, Berlin, Germany German Heart Center Berlin; German Heart Center Berlin Dittrich, S (corresponding author), Deutsch Herzzentrum Berlin, Abt Angeborene Herzfehler, Dept Congenital Heart Dis, Augustenburger Pl 1, D-13353 Berlin, Germany. Dittrich, Sven/T-2753-2019 Dittrich, Sven/0000-0002-8455-3416; Alexi-Meskishvili, Vladimir V./0000-0002-3945-1242; Berger, Felix/0000-0001-7881-1557 BERTRANOU EG, 1978, AM J CARDIOL, V42, P458, DOI 10.1016/0002-9149(78)90941-4; CULLEN S, 1994, J AM COLL CARDIOL, V23, P1151, DOI 10.1016/0735-1097(94)90604-1; DITTRICH S, 1998, Z HERZ THORAX GEFASS, V12, P80; FUSTER V, 1980, AM J CARDIOL, V46, P635, DOI 10.1016/0002-9149(80)90514-7; HORSTKOTTE D, 1993, Z KARDIOL, V82, P552; HU DCK, 1985, J AM COLL CARDIOL, V5, P40, DOI 10.1016/S0735-1097(85)80083-8; JOFFE H, 1994, J AM COLL CARDIOL, V23, P1146, DOI 10.1016/0735-1097(94)90603-3; JONES M, 1977, AM J CARDIOL, V39, P1051, DOI 10.1016/S0002-9149(77)80221-X; KATZ NM, 1982, CIRCULATION, V65, P403, DOI 10.1161/01.CIR.65.2.403; KLINNER W, 1984, THORAC CARDIOV SURG, V32, P244, DOI 10.1055/s-2007-1023394; KOBAYASHI J, 1984, AM J CARDIOL, V54, P1310, DOI 10.1016/S0002-9149(84)80088-0; KRYMSKY LD, 1965, CIRCULATION, V32, P814, DOI 10.1161/01.CIR.32.5.814; LILLEHEI CW, 1955, ANN SURG, V142, P418, DOI 10.1097/00000658-195509000-00010; LUKACS L, 1992, THORAC CARDIOV SURG, V40, P261, DOI 10.1055/s-2007-1020161; MURPHY JG, 1993, NEW ENGL J MED, V329, P593, DOI 10.1056/NEJM199308263290901; Nollert G, 1997, THORAC CARDIOV SURG, V45, P178, DOI 10.1055/s-2007-1013719; PERLOFF JK, 1995, CIRCULATION, V91, P2118, DOI 10.1161/01.CIR.91.8.2118; Perloff Joseph K., 1993, Cardiology Clinics, V11, P689; REDDY VM, 1995, ANN THORAC SURG, V60, P592; ROSENTHAL A, 1984, ANN THORAC SURG, V38, P151, DOI 10.1016/S0003-4975(10)62224-2; RYGG IH, 1971, DAN MED BULL, V18, P25; WAIEN SA, 1992, J AM COLL CARDIOL, V20, P295, DOI 10.1016/0735-1097(92)90093-3; WALSH EP, 1988, CIRCULATION, V77, P1062, DOI 10.1161/01.CIR.77.5.1062; YANKAH AC, 1982, THORAC CARDIOV SURG, V30, P69, DOI 10.1055/s-2007-1022213; ZHAO HX, 1985, J THORAC CARDIOV SUR, V89, P204 25 34 40 0 2 CLINICAL CARDIOLOGY PUBL CO MAHWAH PO BOX 832, MAHWAH, NJ 07430-0832 USA 0160-9289 CLIN CARDIOL Clin. Cardiol. JUL 1999 22 7 460 464 10.1002/clc.4960220705 http://dx.doi.org/10.1002/clc.4960220705 5 Cardiac & Cardiovascular Systems Science Citation Index Expanded (SCI-EXPANDED) Cardiovascular System & Cardiology 212LT 10410289 Green Published 2024-02-29 WOS:000081218700007 J Dixon, AFG; Kindlmann, P Dixon, AFG; Kindlmann, P Cost of flight apparatus and optimum body size of aphid migrants ECOLOGY English Article aphids; cost of flight apparatus; insects; migration; optimum body size WING-DIMORPHIC CRICKET; AFRICAN ARMYWORM MOTH; SPODOPTERA-EXEMPTA; REPRODUCTIVE INVESTMENT; ONCOPELTUS-FASCIATUS; MEGOURA-VICIAE; VETCH APHID; TRADE-OFF; MIGRATION; ALLOCATION The incorporation of aerodynamic considerations into an optimal energy partitioning model developed for aphids results in the prediction that migrants should be smaller and take longer to develop than nonmigrants. If individuals are structurally similar (i.e., the relative sizes of body parts and flight apparatus are similar), then both within and between species, aerodynamic considerations predict that biomass of wing muscles should scale relative to body mass with an exponent between 1 and 7/6, and wing beat frequency directly proportional to wing length for maximum power output to 1/2 power of wing length, when cruising. The empirical results for aphids indicate that within species, individuals of different sizes may not be structurally identical: large individuals appear to have proportionally smaller wings, and as theory predicts, appear to compensate for this by having proportionally larger wing muscles than small individuals. Interspecifically, aphids appear to be structurally identical both in terms of wing area, wing beat frequency, and in the relative size of the thorax. As predicted both intra- and interspecifically, large migrants, although having larger gonads, nevertheless have proportionally smaller gonads than small migrants. Empirical results also conform to the prediction that migrants should be smaller than nonmigrants, particularly so in large species. The prediction that the developmental time for migrants should be longer than for nonmigrants is supported by published data for aphids. The significance of these Endings is discussed in the context of Roff's hypothesis that insect migrants should be larger and develop faster than nonmigrants. Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England; Univ S Bohemia, Fac Biol Sci, Ceske Budejovice 37005, Czech Republic; Acad Sci Czech Republic, CR-37005 Ceske Budejovice, Czech Republic University of East Anglia; Czech Academy of Sciences; University of South Bohemia Ceske Budejovice; Czech Academy of Sciences Dixon, AFG (corresponding author), Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England. a.f.dixon@uea.ac.uk Kindlmann, Pavel/H-7718-2014 Kindlmann, Pavel/0000-0003-4772-1182 ANGELO MJ, 1984, FLA ENTOMOL, V67, P22, DOI 10.2307/3494102; [Anonymous], 1981, Statistical Tables; [Anonymous], COMPREHENSIVE INSECT; BROUGH CN, 1989, FUNCT ECOL, V3, P747, DOI 10.2307/2389507; BROUGH CN, 1990, ENTOMOL EXP APPL, V56, P269, DOI 10.1007/BF00163698; BROWER LP, 1985, U TEXAS CONTRIB MA S, V27, P748; CASEY TM, 1976, J EXP BIOL, V64, P529; COCKBAIN AJ, 1961, J EXP BIOL, V38, P163; Dixon A.F.G., 1986, P145; DIXON AFG, 1993, J ANIM ECOL, V62, P182, DOI 10.2307/5492; DIXON AFG, 1969, J ANIM ECOL, V38, P585, DOI 10.2307/3037; DIXON AFG, 1968, NATURE, V220, P1337, DOI 10.1038/2201337a0; DIXON AFG, 1983, ENTOMOLOGIA EXPT APP, V33, P33; DUDLEY R, 1990, J COMP PHYSIOL A, V167, P145; ELLINGTON CP, 1990, NATURE, V347, P472, DOI 10.1038/347472a0; ELLINGTON CP, 1991, J EXP BIOL, V160, P71; GUNN A, 1986, PHYSIOL ENTOMOL, V11, P423, DOI 10.1111/j.1365-3032.1986.tb00433.x; GUNN A, 1993, PHYSIOL ENTOMOL, V18, P149, DOI 10.1111/j.1365-3032.1993.tb00462.x; HARRINGTON R, 1990, J ANIM ECOL, V59, P1177, DOI 10.2307/5039; HARRISON RG, 1980, ANNU REV ECOL SYST, V11, P95, DOI 10.1146/annurev.es.11.110180.000523; HARVEY PH, 1991, COMP METHODS EVOLUTI; Heie O. 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Dixon R, 1998, CEPHALALGIA, V18, P468, DOI 10.1046/j.1468-2982.1998.1807468.x; Proietti-Cecchini A, 1997, CEPHALALGIA, V17, P849, DOI 10.1046/j.1468-2982.1997.1708849.x; Schoenen J, 1985, MIGRAINE, P17; Wang W, 1996, NEUROLOGY, V46, P1404, DOI 10.1212/WNL.46.5.1404 4 3 3 0 0 SCANDINAVIAN UNIVERSITY PRESS OSLO PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY 0333-1024 CEPHALALGIA Cephalalgia JUL 1999 19 24 29 31 10.1177/0333102499019S2407 http://dx.doi.org/10.1177/0333102499019S2407 3 Clinical Neurology; Neurosciences Science Citation Index Expanded (SCI-EXPANDED) Neurosciences & Neurology 225QW 10526680 2024-02-29 WOS:000081973100007 J Dizon, RM; Yap, HT Dizon, RM; Yap, HT Short-term responses of coral reef microphytobenthic communities to inorganic nutrient loading LIMNOLOGY AND OCEANOGRAPHY English Article BENTHIC MICROALGAL COMMUNITIES; WATER SEDIMENT SYSTEM; MICROBIAL MAT; ENERGY-FLOW; PHYTOPLANKTON; GROWTH; LIGHT; PHOTOSYNTHESIS; PHILIPPINES; SEASONALITY The responses of coral reef hat microphytobenthos to short-term exposure to elevated levels of inorganic nitrogen (N) and phosphorus (P) were investigated in 1994 and 1995. Sand samples collected from the reef flat were maintained over 7 d in triplicate cultures with N-enriched (100 mu M NO3), P-enriched (10 mu M PO4), and ambient seawater. A fourth experiment used a treatment of combined N and P enrichment. The sediment samples were assessed for chlorophyll a (Chl a) content and photosynthesis-irradiance (P-I) responses. P-I curves, constructed from area- and Chi a-specific metabolic rates, showed consistently higher maximal rates in the nutrient-enriched samples. Sediments exposed to enhanced levels of N exhibited the highest Chi a content while both N- and P-enriched samples showed increased photosynthetic yield. Very little depletion of nutrients in the water column was detected over time in the batch cultures except in the N+P-enriched treatments where nutrient values dropped to near-ambient levels. Results from these experiments point to N and P colimitation in tropical carbonate sediments. Univ Philippines, Inst Marine Sci, Quezon 1101, Philippines University of the Philippines System; University of the Philippines Diliman Dizon, RM (corresponding author), Univ Philippines, Inst Marine Sci, Quezon 1101, Philippines. 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Oceanogr. JUL 1999 44 5 1259 1267 10.4319/lo.1999.44.5.1259 http://dx.doi.org/10.4319/lo.1999.44.5.1259 9 Limnology; Oceanography Science Citation Index Expanded (SCI-EXPANDED) Marine & Freshwater Biology; Oceanography 219ZN Bronze 2024-02-29 WOS:000081639000007 J Djavan, B; Ghawidel, K; Basharkhah, A; Hruby, S; Bursa, B; Marberger, M Djavan, B; Ghawidel, K; Basharkhah, A; Hruby, S; Bursa, B; Marberger, M Temporary intraurethral prostatic bridge-catheter compared with neoadjuvant and adjuvant alpha-blockade to improve early results of high-energy transurethral microwave thermotherapy UROLOGY English Article DOUBLE-BLIND; CLINICAL-TRIAL; HYPERPLASIA; MULTICENTER; STENTS Objectives. The maximal effect of transurethral microwave thermotherapy (TUMT) for lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH) occurs 3 to 6 months after treatment. In the acute period after TUMT, little change in symptoms, quality of life (QOL), and peak urinary flow rate (Qmax) is observed versus baseline. Some men may also develop acute urinary retention secondary to thermally induced edema. Recent reports suggest that early results of TUMT may be improved with concomitant use of either a temporary intraurethral prostatic bridge-catheter (PBC) or neoadjuvant and adjuvant alpha-blocker therapy. This report compares the results of these two adjunctive modalities directly. Methods. This nonrandomized retrospective comparison of results in 186 patients with LUTS of BPH is based on findings of three recently reported prospective clinical trials. All patients underwent targeted high-energy TUMT. Ninety-one patients received no further treatment (TUMT alone group), 54 an indwelling PBC for up to 1 month (TUMT + PBC group), and 41 neoadjuvant and adjuvant tamsulosin (0.4 mg daily) treatment (TUMT + tamsulosin group). The International Prostate Symptom Score (IPSS), QOL score, and Qmax were determined at baseline and 2 weeks after TUMT. Results. All three study groups experienced statistically significant improvements in mean IPSS and QOL score at 2 weeks versus baseline (P <0.0005). Nevertheless, the magnitude of improvement was greater in the TUMT + PBC group than the other two groups and greater in the TUMT + tamsulosin group than the TUMT alone group. A high proportion of the TUMT + PBC group (87.8%) attained a 50% or more IPSS improvement, compared with 4.5% of the TU MT alone group and none of the TU MT + tamsulosin group, and a similar pattern of between-group differences was noted with respect to the proportion of patients having 50% or more improvement in QOL score. The TUMT + PBC group was the only group to achieve significant Qmax improvement at 2 weeks compared with baseline. In the TUMT alone group, urinary retention 1 week or longer in duration occurred in 10 (11%) of 91 patients compared with 1 (2.4%) of 41 in the TUMT + tamsulosin group and none in the TUMT + PBC group. Early PBC removal was required in 11% of the TUMT + PBC group as a consequence of urinary retention secondary to clot formation or PBC migration. Conclusions. Both PBC placement and neoadjuvant and adjuvant alpha-blocker treatment are effective in alleviating symptoms and improving QOL during the acute period after TUMT. PBC usage also resulted in substantial early Qmax improvement. Either of these adjunctive modalities may be appropriate to consider in the treatment of TUMT patients during the early postprocedure recovery period. UROLOGY 54: 73-80, 1999. (C) 1999, Elsevier Science Inc. Univ Vienna, Dept Urol, A-1090 Vienna, Austria University of Vienna Djavan, B (corresponding author), Univ Vienna, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. BARRY MJ, 1995, J UROLOGY, V154, P1770, DOI 10.1016/S0022-5347(01)66780-6; Blute ML, 1996, J ENDOUROL, V10, P565, DOI 10.1089/end.1996.10.565; Dahlstrand C, 1997, BRIT J UROL, V79, P907, DOI 10.1046/j.1464-410X.1997.00186.x; Devonec M, 1998, WORLD J UROL, V16, P120, DOI 10.1007/s003450050037; deWildt MJAM, 1996, UROLOGY, V48, P416, DOI 10.1016/S0090-4295(96)00189-6; Djavan B, 1997, J UROLOGY, V158, P1829, DOI 10.1016/S0022-5347(01)64139-9; Djavan B, 1998, J UROLOGY, V160, P772, DOI 10.1016/S0022-5347(01)62783-6; Djavan B, 1999, J UROLOGY, V161, P144, DOI 10.1016/S0022-5347(01)62085-8; Djavan B, 1999, J UROLOGY, V161, P139, DOI 10.1016/S0022-5347(01)62084-6; Djavan B, 1998, UROLOGY, V52, P935, DOI 10.1016/S0090-4295(98)00471-3; Djavan B, 1999, UROLOGY, V53, P251, DOI 10.1016/S0090-4295(98)00538-X; Larson TR, 1998, UROLOGY, V51, P731, DOI 10.1016/S0090-4295(97)00710-3; Petas A, 1997, J UROLOGY, V157, P173, DOI 10.1016/S0022-5347(01)65316-3; Ramsey EW, 1998, WORLD J UROL, V16, P96, DOI 10.1007/s003450050033; Roehrborn CG, 1998, UROLOGY, V51, P19, DOI 10.1016/S0090-4295(97)00571-2 15 8 9 0 0 ELSEVIER SCIENCE INC NEW YORK 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA 0090-4295 UROLOGY UROLOGY JUL 1999 54 1 73 80 10.1016/S0090-4295(99)00029-1 http://dx.doi.org/10.1016/S0090-4295(99)00029-1 8 Urology & Nephrology Science Citation Index Expanded (SCI-EXPANDED) Urology & Nephrology 213BA 10414730 2024-02-29 WOS:000081251100017 J Dmitruk, N; Lepeshkina, T; Pavlovska, M; Zabashta, L Dmitruk, N; Lepeshkina, T; Pavlovska, M; Zabashta, L Polarizability of gold clusters on the GaAs surface NANOSTRUCTURED MATERIALS English Article; Proceedings Paper 4th International Conference on Nanostructured Materials (NANO 98) JUN 14-19, 1998 STOCKHOLM, SWEDEN Royal Inst Technol, Sweden, Swedish Consortium Clusters & Ultrafine Particles, Sweden, Royal Inst Technol, Brinell Ctr, Sweden, European Consortium Nanophase Mat, Switzerland, Acta Met Inc, USA, Alps Elect Co, Japan, Canon Ctr City, Sweden, Carl Tryggers Stiftelse, Sweden, Elsevier Sci Inc, Switzerland, Finnair, Finland, Off Naval Res ONR, USA, European Res Off US Army, USARDSD-UK, Swedish Nat Sci Res Council, NFR, Sweden, Swedish Res Council Engn Sci, TFR, Sweden, Swedish Nat Board Ind & Tech Dev (NUTEK), Swedish Royal Acad Sci, Nobel Comm Phys, Sweden, Swedish Royal Acad Sci, Nobel comm Chem, Sweden Here we used the chemical method of deposition of nanoparticles from wafer solution of metal salts on a less electropositivity substrates. The size-dependent polarizability of Au nanoparticles on the GaAs substrate was investigated by reflective ellipsometry methods: MAI and VASE. (C) 1999 Acta Metallurgica Inc. NASU, Inst Semicond Phys, UA-252650 Kiev, Ukraine; Taras Shevchenko Natl Univ, Kyiv, Ukraine; Sumy State Univ, Sumy, Ukraine National Academy of Sciences Ukraine; Lashkaryov Institute of Semiconductor Physics; Ministry of Education & Science of Ukraine; Taras Shevchenko National University of Kyiv; Ministry of Education & Science of Ukraine; Sumy State University Dmitruk, N (corresponding author), NASU, Inst Semicond Phys, 45 Prosp Nauki, UA-252650 Kiev, Ukraine. 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JUL 1999 12 1-4 A SI 295 298 10.1016/S0965-9773(99)00120-8 http://dx.doi.org/10.1016/S0965-9773(99)00120-8 4 Materials Science, Multidisciplinary Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED) Materials Science 224RM 2024-02-29 WOS:000081912100067 J Do, JS; Her, AS Do, JS; Her, AS Mass transfer and current efficiency for the electrodeposition of silver in fluorosilicic acid solution JOURNAL OF APPLIED ELECTROCHEMISTRY English Article current efficiency; electrodeposition; fluorosilicic acid; mass transfer; silver POWDER The stripping and electrodeposition of silver in fluorosilicic acid solution are irreversible reactions as indicated by cyclic voltammetry. The rate constant for the intrinsic heterogeneous cathodic deposition of silver was obtained as k(C)(o) = 40.77 exp(1.88 - 29.43 E-C(o') and the diffusion coefficient of the silver ion in fluorosilicic acid solution as 5.17 x 10(-5) cm(2) s(-1). Theoretical calculations of the concentration of silver ion correlated well with experimental data. The relationship between the diffusion layer thickness and the stirring rate was also obtained. Increasing the stirring rate and temperature, and decreasing the current density and concentration of fluorosilicic acid, caused an increase in the current efficiency for silver deposition on graphite. Tunghai Univ, Dept Chem Engn, Taichung 40704, Taiwan Tunghai University Do, JS (corresponding author), Tunghai Univ, Dept Chem Engn, Taichung 40704, Taiwan. Bard A. 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JUL 1999 29 7 829 836 8 Electrochemistry Science Citation Index Expanded (SCI-EXPANDED) Electrochemistry 209EQ 2024-02-29 WOS:000081035600007 J Docherty, JC; Kuzio, B; Silvester, JA; Bowes, J; Thiemermann, C Docherty, JC; Kuzio, B; Silvester, JA; Bowes, J; Thiemermann, C An inhibitor of poly (ADP-ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart BRITISH JOURNAL OF PHARMACOLOGY English Article ATP; creatine phosphate; global ischaemia; NMR; reperfusion injury; PARS; poly (ADP-ribose) polymerase; reactive oxygen species FREE-RADICAL GENERATION; DNA STRAND-BREAKS; POLY(ADP-RIBOSE) POLYMERASE; SUPEROXIDE-DISMUTASE; MYOCARDIAL-ISCHEMIA; STUNNED MYOCARDIUM; HYDROGEN-PEROXIDE; CARDIAC MYOBLASTS; PATHO-PHYSIOLOGY; CALCIUM OVERLOAD 1 The cardioprotective properties of inhibition of poly (ADP-ribose) synthetase (PARS) were investigated in the isolated perfused heart of the rat. Hearts were perfused in the Langendorff mode and subjected to 23 min total global ischaemia and reperfused for 60 min. 2 Left ventricular function was assessed by means of an intra-ventricular balloon. High energy phosphates were measured by P-31-NMR spectroscopy. Intracellular levels of NAD were measured by capillary electrophoresis of perchloric acid extracts of hearts at the end of reperfusion. 3 Reperfusion in the presence of the PARS inhibitor 1,5 didroxyisoquinoline (ISO, 100 mu M) attenuated the mechanical dysfunction observed following 1 h of reperfusion; 27+/-13 and 65+/-8% recovery of preischaemic rate pressure product for control and 100 mu M ISO, respectively. 4 This cardioprotection was accompanied by a preservation of intracellular high-energy phosphates during reperfusion; 38+/-2 vs 58+/-4% (P<0.05) of preischaemic levels of phosphocreatine (PCr) for control and 100 mu M ISO respectively and 23 fl vs 31+/-3% (P<0.05) of preischaemic levels of ATP for control and 100 mu M ISO respectively. 5 Cellular levels of NAD were higher in ISO treated hearts at the end of reperfusion; 2.56+/-0.45 vs 4.76+/-1.12 mu moles g(-1) dry weight (P<0.05) for control and ISO treated. 6 These results demonstrate that the cardioprotection afforded by inhibition of PARS activity with ISO is accompanied by a preservation of high-energy phosphates and cellular NAD levels and suggest that the mechanism responsible for this cardioprotection may involve prevention of intracellular ATP depletion. St Bartholomews & Royal London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England; Natl Res Council Canada, Inst Biodiagnost, Winnipeg, MB R3B 1Y6, Canada University of London; Queen Mary University London; National Research Council Canada Thiemermann, C (corresponding author), St Bartholomews & Royal London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England. 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J. Pharmacol. JUL 1999 127 6 1518 1524 10.1038/sj.bjp.0702705 http://dx.doi.org/10.1038/sj.bjp.0702705 7 Pharmacology & Pharmacy Science Citation Index Expanded (SCI-EXPANDED) Pharmacology & Pharmacy 223FV 10455304 Green Published 2024-02-29 WOS:000081831000027 J Dockerty, J; McBride, M; Miller, A; Ahlbom, A Dockerty, J; McBride, M; Miller, A; Ahlbom, A EMF and childhood leukemia EPIDEMIOLOGY English Meeting Abstract 0 0 0 0 0 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1044-3983 EPIDEMIOLOGY Epidemiology JUL 1999 10 4 517SO S174 S174 1 Public, Environmental & Occupational Health Science Citation Index Expanded (SCI-EXPANDED) Public, Environmental & Occupational Health 208JK 2024-02-29 WOS:000080987100547 J Dockerty, JD; Skegg, DCG; Elwood, JM; Herbison, GP; Becroft, DMO; Lewis, ME Dockerty, JD; Skegg, DCG; Elwood, JM; Herbison, GP; Becroft, DMO; Lewis, ME Infections, vaccinations, and the risk of childhood leukaemia BRITISH JOURNAL OF CANCER English Article epidemiology; leukaemia; infection; vaccination; case-control studies; influenza ACUTE LYMPHOBLASTIC-LEUKEMIA; ETIOLOGY A nationwide case-control study was conducted in New Zealand, to test hypotheses about the role of infections in the aetiology of childhood leukaemia. Children aged 0-14 years with leukaemia were matched on age and sex to controls selected from birth records. Case ascertainment was virtually complete and 121 (92%) of 131 eligible case families took part. The participation rate among the 303 first-choice eligible controls was 69%. Home interviews and serological tests were conducted. Adjusted relative risks were estimated by logistic regression. There was an increased risk of leukaemia in relation to reported influenza infection of the child during the first year of life (adjusted odds ratio 6.8, 95% confidence interval 1.8-25.7). This could be a chance finding due to multiple comparisons, and it should be tested elsewhere. Some key variables relevant to Greaves' hypothesis were not associated with B-cell precursor acute lymphoblastic leukaemia (numbers of infections and vaccinations, firstborn status, attendance at preschool groups), although a smalt effect could not be ruled out with a study of this size. Leukaemia risk was higher among children in poorer social circumstances, and this was true for all eligible children as well as for the participants. Univ Oxford, Childhood Canc Res Grp, Oxford OX2 6HJ, England; Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand; Univ Auckland, Natl Womens Hosp, Dept Obstet & Gynaecol, Auckland, New Zealand; Wellington Sch Med, Dept Paediat, Wellington S, New Zealand University of Oxford; University of Otago; University of Auckland; University of Otago Dockerty, JD (corresponding author), Univ Oxford, Childhood Canc Res Grp, 57 Woodstock Rd, Oxford OX2 6HJ, England. 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CAMPBELL CA, 1994, LANCET, V343, P109; CAMPBELL CA, 1996, POSTGRAD MED J S2, V72, pS11; FitzSimmons SC, 1997, NEW ENGL J MED, V336, P1283, DOI 10.1056/NEJM199705013361803; Oppenheimer E H, 1975, Perspect Pediatr Pathol, V2, P241; Ramsden WH, 1998, ARCH DIS CHILD, V79, P339, DOI 10.1136/adc.79.4.339; SMYTH RL, 1995, LANCET, V346, P1247, DOI 10.1016/S0140-6736(95)91860-4 6 0 0 0 0 BRITISH MED JOURNAL PUBL GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 0003-9888 ARCH DIS CHILD Arch. Dis. Child. JUL 1999 81 1 97 97 1 Pediatrics Science Citation Index Expanded (SCI-EXPANDED) Pediatrics 213QD 2024-02-29 WOS:000081284000027 J Dodson, AH; Moore, T; Baker, DF; Swann, JW Dodson, Alan H.; Moore, Terry; Baker, David F.; Swann, John W. Hybrid GPS plus GLONASS GPS SOLUTIONS English Article Data Processing; GNSS; Hybrid System; Frequency Diversity; Signal Frequency The hybridization of GPS with GLONASS has formed a first stage in GNSS development. We examine the performance of the hybrid system in the position domain for both code and carrier phase cases. Several major differences exist between GPS and GLONASS; most significant is GLONASS's signal frequency diversity, which can lead to measurement bias, particularly so when a pair of receivers are operating at different temperatures. Unless signal frequency diversity is addressed either on-receiver or at the data processing stage, positioning errors can occur at the centimeter level. We outline the difficulties of combining observations from the two systems and discuss how these may be overcome. (c) 1999 John Wiley & Sons, Inc. [Dodson, Alan H.; Moore, Terry; Baker, David F.; Swann, John W.] Univ Nottingham, IESSG, Nottingham NG7 2RD, England University of Nottingham Dodson, AH (corresponding author), Univ Nottingham, IESSG, Nottingham NG7 2RD, England. Engineering and Physical Sciences Research Council (EPSRC); Quest Ltd; University of Nottingham Engineering and Physical Sciences Research Council (EPSRC)(UK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC)); Quest Ltd; University of Nottingham The research into hybrid GPS and GLONASS data processing, at the IESSG, is supported by the Engineering and Physical Sciences Research Council (EPSRC), Quest Ltd, and the University of Nottingham. The support of all sponsors is gratefully acknowledged by the authors. [Anonymous], 1997, TSA 100 TEMPERATURE; Povalyaev AA, 1996, MEAS TECH+, V39, P516, DOI 10.1007/BF02375761; Walsh D, 1997, IEEE CONFERENCE ON INTELLIGENT TRANSPORTATION SYSTEMS, P514, DOI 10.1109/ITSC.1997.660527 3 11 11 0 0 SPRINGER HEIDELBERG HEIDELBERG TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY 1080-5370 1521-1886 GPS SOLUT GPS Solut. JUL 1999 3 1 32 41 10.1007/PL00012777 http://dx.doi.org/10.1007/PL00012777 10 Remote Sensing Science Citation Index Expanded (SCI-EXPANDED) Remote Sensing VI7OA 2024-02-29 WOS:000511700300007 J Doherty, DF; Nakano, J; Nakano, K Doherty, DF; Nakano, J; Nakano, K Neutrophil-derived heparin-binding protein -: A monocyte-specific chemoattractant that induces monocyte migration into rabbit lungs in vivo CHEST English Article; Proceedings Paper 41st Annual Thomal L Petty Aspen Lung Conference on Acute Lung Injury JUN 03-06, 1998 ASPEN, COLORADO 3M Pharmaceut, Alliance Pharmaceut Corp, Astra USA, Bayer Pharmaceut Div, Boehringer Ingelheim Pharmaceut Inc, Bristol-Myers Squibb Oncol, Dura Pharmaceut, Eli Lilly & Co Inc, Genetech Inc, Glaxo Wellcome, Hoechst Marion Roussel Inc, Human Genome Sci Inc, Invitrogen Corp, Key Pharmaceut, Merck Res Labs & Merck Frosst Canada, NEXSTAR Pharmaceut Inc, Novartis Pharmaceut Corp, Ohmeda Inc, Ortho-McNeil Pharmaceut Inc, PathoGenesis Corp, Pfizer Inc, Pharmacia & Upjohn, Rhone-Poulenc Rorer Pharmaceut, Roche Labs, Sanofi Winthrop Inc, Schering Corp, Teijin Ltd, Wallace Labs, Zeneca Pharmaceut, Francis Families Fdn, Respiratory Distress Syndrome Fdn, Aspen Lung Conf Endowment Fund Univ Kentucky, Albert B Chandler Med Ctr, Lexington Vet Adm Med Ctr, Div Pulm & Crit Care Med, Lexington, KY 40536 USA; Natl Jewish Med & Res Ctr, Dept Med, Denver, CO USA University of Kentucky; US Department of Veterans Affairs; Veterans Health Administration (VHA); Lexington VA Medical Center; National Jewish Health Doherty, DF (corresponding author), Univ Kentucky, Albert B Chandler Med Ctr, Lexington Vet Adm Med Ctr, Div Pulm & Crit Care Med, 800 Rose St,MN 614, Lexington, KY 40536 USA. 0 4 4 0 1 AMER COLL CHEST PHYSICIANS NORTHBROOK 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA 0012-3692 CHEST Chest JUL 1999 116 1 S 34S 35S 10.1378/chest.116.suppl_1.34S-a http://dx.doi.org/10.1378/chest.116.suppl_1.34S-a 2 Critical Care Medicine; Respiratory System Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED) General & Internal Medicine; Respiratory System 220CC 10424582 2024-02-29 WOS:000081646100027 J Dolimbek, BZ; Atassi, MZ Dolimbek, BZ; Atassi, MZ Capacity of antibodies to synthetic peptides of α-bungarotoxin for recognizing conformational sections of the neurotoxin molecule CHEMISTRY OF NATURAL COMPOUNDS English Article PROTEIN ANTIGENIC STRUCTURES; SITES The capacity of antibodies to various synthetic peptides of alpha-bungarotoxin for binding peptides of the neurotoxin and recognizing the corresponding regions of the alpha-bungarotoxin molecule has been investigated. It has been established that individual conformational sections of the alpha-bungarotoxin molecule are specifically recognized by antibodies to synthetic epitopes of the neuroroxin. Acad Sci Republ Uzbekistan, AS Sadykov Bioorgan Chem Inst, Tashkent, Uzbekistan; Baylor Coll Med, Houston, TX 77030 USA Academy of Sciences of Uzbekistan; Sadykov Institute of Bioorganic Chemistry; Baylor College of Medicine Dolimbek, BZ (corresponding author), Acad Sci Republ Uzbekistan, AS Sadykov Bioorgan Chem Inst, Tashkent, Uzbekistan. 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JUL-AUG 1999 35 4 448 451 10.1007/BF02282516 http://dx.doi.org/10.1007/BF02282516 4 Chemistry, Medicinal; Chemistry, Organic Index Chemicus (IC); Science Citation Index Expanded (SCI-EXPANDED) Pharmacology & Pharmacy; Chemistry 299ZH 2024-02-29 WOS:000086228000017 J Donaghy, M; Kennett, R Donaghy, M; Kennett, R Varying occurrence of vocal cord paralysis in a family with autosomal dominant hereditary motor and sensory neuropathy JOURNAL OF NEUROLOGY English Article hereditary motor and sensory neuropathy type IIC; vocal cord paralysis; abducens nerve palsy CHARCOT; MARIE; TOOTH A white British family with the axonal form of hereditary motor and sensory neuropathy (HMSN, type II) contained one member who developed a recurrent laryngeal nerve palsy at the age of 41 years, in addition to 4 years of symptomatic polyneuropathy and an abducens nerve palsy. Neither of the other family members (the mother and sister) with electrophysiologically confirmed polyneuropathy had any neuropathic symptoms in the limbs or laryngeal or respiratory muscle involvement. An autosomal dominant pattern of inheritance is likely. This is a second report of this rare form of HMSN (type IIC) in which there is associated laryngeal or respiratory muscle weakness. This family differs from the two previously reported pedigrees in which laryngeal or diaphragm weakness had commenced within the first two decades. The discovery of asymptomatic family members attests to the diagnostic value of clinical and electrophysiological study of first-degree relatives when laryngeal or bulbar symptoms develop in the context of chronic axonal polyneuropathy. HMSN type IIC should be distinguished from the more common forms of HMSN - type IIA, in which axonal polyneuropathy is restricted to the limbs, and type IIB, which is of early onset and associated with foot ulceration. 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World JUL 1999 22 7 46 48 3 Computer Science, Software Engineering Science Citation Index Expanded (SCI-EXPANDED) Computer Science 394UT 2024-02-29 WOS:000166542200017 J Dong, TZ; Mankbadi, RR Dong, TZ; Mankbadi, RR Simulation of unsteady flow in nozzle-ejector mixer JOURNAL OF PROPULSION AND POWER English Article; Proceedings Paper AIAA/CEAS 2nd Joint Aeroacoustics Conference MAY 06-08, 1996 STATE COLL, PENNSYLVANIA AIAA, CEAS FINITE-DIFFERENCE SCHEMES; BOUNDARY-CONDITIONS A numerical-simulation capability is developed with emphasis on capturing the flow and acoustic disturbances in internal flows. The configuration considered is that of a circular ejector with single element primary nozzle. The Favre-filtered Navier-Stokes equations with a subgrid model are used to simulate the large scale structure. The high-order dispersion relation-preserving scheme is used to minimize dispersion and dissipation errors. Special boundary treatments are adopted for inflow, outflow, and solid walls to eliminate nonphysical reflections. Results show the growth of the disturbances, the formation of weak shock-cell structures, and the propagation of acoustic waves. NASA, John H Glenn Res Ctr Lewis Field, Cleveland, OH 44135 USA National Aeronautics & Space Administration (NASA); NASA Glenn Research Center Dong, TZ (corresponding author), NASA, John H Glenn Res Ctr Lewis Field, Cleveland, OH 44135 USA. AHUJA KJ, 1996, 960639 AIAA; CRAIK ADD, 1986, LAMINAR TURBULENT TR, P1; DONG TZ, 1995, 95064 AIAA CEAS; DONG TZ, 1995, P ICASE LARC WORKSH, P285; DONG TZ, 1997, 97164 AIAA; EDISON TM, 1985, J FLUID MECH, V158, P245; ENGQUIST B, 1977, MATH COMPUT, V31, P629, DOI 10.1090/S0025-5718-1977-0436612-4; ERLEBACHER G, 1992, J FLUID MECH, V238, P155, DOI 10.1017/S0022112092001678; HUFF DL, 1998, 980177 AIAA; JONES RR, 1993, 930731 AIAA; Liu J.T.C., 1988, Adv. Appl. 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Power JUL-AUG 1999 15 4 539 543 10.2514/2.5476 http://dx.doi.org/10.2514/2.5476 5 Engineering, Aerospace Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED) Engineering 217QY 2024-02-29 WOS:000081511500007 J Dorfman, YA; Polimbetova, GS; Aleshkova, MM; Borangazieva, AK Dorfman, YA; Polimbetova, GS; Aleshkova, MM; Borangazieva, AK Oxidative phosphine arylation and hydroxyalkylation with n-benzoquinone and alcohol in the coordination sphere of palladium(II) complexes RUSSIAN JOURNAL OF COORDINATION CHEMISTRY English Article PHOSPHORUS It was established that PdCl2 forms with PH3 palladium(II) chlorophosphide (PdCl)(3)P, which undergoes new fast and selective reactions of oxidative phosphine arylation and hydroxyalkylation in dioxane and alcohol solutions of n-benzoquinone. NMR spectroscopy, gas chromatography, potentiometry, and chemical modeling methods were used to demonstrate that the formation of the intermediate pi-complex of (PdCl)(3)P and n-benzoquinone is the rate-limiting step of these reactions. Kazakh Acad Sci, DV Sokolskii Organ Catalysis & Electrochem Inst, Almaty, Kazakhstan Kazakh British Technical University; DV Sokolsky Institute of Fuel Catalysis & Electrochemistry; National Academy of Sciences of the Republic of Kazakhstan Dorfman, YA (corresponding author), Kazakh Acad Sci, DV Sokolskii Organ Catalysis & Electrochem Inst, Almaty, Kazakhstan. Kamalovna, Akbope/AAQ-9373-2020; Полимбетова, Гульшара/AAP-1947-2021 AXELRAD G, 1981, J ORG CHEM, V46, P5200, DOI 10.1021/jo00338a028; DORFMAN YA, 1993, USP KHIM+, V62, P928; Dorfman YA, 1995, ZH OBSHCH KHIM+, V65, P1849; DORFMAN YA, 1995, KOORDINATS KHIM+, V21, P191; DORFMAN YA, 1994, JAP FSU CAT SEM 94 C, P78; Dorfman Ya. 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Nauk SSSR, P1660; RUDAKOV ES, 1977, METALLOKOMPLEKSNYI K, P85; SHULYNDIN SV, 1981, USP KHIM+, V50, P1653; TARABANKO VE, 1978, ISSLEDOVANIE SVOISTV, P182; TAVS P, 1970, TETRAHEDRON, V26, P5529; Temkin O.N., 1991, Acetylene. Chemistry. Reaction Mechanisms. Technology; TEMKIN ON, 1978, GOMOGENNOE OKISLENIE, P3; TEMKIN ON, 1995, RUSS KOR SEM CAT NOV, V2, P54; WESFMIJZE H, 1977, RECL TRAV CHIM PAY B, V96, P194 36 0 0 0 1 MAIK NAUKA/INTERPERIODICA NEW YORK C/O PLENUM/CONSULTANTS BUREAU 233 SPRING ST, NEW YORK, NY 10013 USA 1070-3284 RUSS J COORD CHEM+ Russ. J. Coord. Chem. JUL 1999 25 7 487 493 7 Chemistry, Inorganic & Nuclear Science Citation Index Expanded (SCI-EXPANDED) Chemistry 217KK 2024-02-29 WOS:000081498300007 J Dormann, JL; Fiorani, D; Cherkaoui, R; Spinu, L; Lucari, F; D'Orazio, F; Noguès, M; Tronc, E; Jolivet, JP; Garcia, A Dormann, JL; Fiorani, D; Cherkaoui, R; Spinu, L; Lucari, F; D'Orazio, F; Noguès, M; Tronc, E; Jolivet, JP; Garcia, A Collective glass state in a magnetic nanoparticle system NANOSTRUCTURED MATERIALS English Article; Proceedings Paper 4th International Conference on Nanostructured Materials (NANO 98) JUN 14-19, 1998 STOCKHOLM, SWEDEN Royal Inst Technol, Sweden, Swedish Consortium Clusters & Ultrafine Particles, Sweden, Royal Inst Technol, Brinell Ctr, Sweden, European Consortium Nanophase Mat, Switzerland, Acta Met Inc, USA, Alps Elect Co, Japan, Canon Ctr City, Sweden, Carl Tryggers Stiftelse, Sweden, Elsevier Sci Inc, Switzerland, Finnair, Finland, Off Naval Res ONR, USA, European Res Off US Army, USARDSD-UK, Swedish Nat Sci Res Council, NFR, Sweden, Swedish Res Council Engn Sci, TFR, Sweden, Swedish Nat Board Ind & Tech Dev (NUTEK), Swedish Royal Acad Sci, Nobel Comm Phys, Sweden, Swedish Royal Acad Sci, Nobel comm Chem, Sweden FINE-PARTICLE SYSTEMS; GAMMA-FE2O3 NANOPARTICLES; INTERPARTICLE INTERACTIONS; SPIN-GLASS; RELAXATION; MOMENTS Studies of static and dynamic properties of gamma-Fe2O3 particle ( 5 nm) assemblies reveal the existence of three magnetic regimes with increasing strength of the interparticle interactions: pure superparamagnetic for very weak interactions, modified superparamagnetic for weak-medium interactions, and collective for strong interactions. The East presents a low-temperature state similar to the spin-glass state, but the glass transition shows distinct features. (C)1999 Acta Metallurgica Inc. Univ Versailles, CNRS, LMOV, F-78035 Versailles, France; CNR, ICMAT, I-00016 Rome, Italy; Univ Aquila, Dipartimento Fis, INFM, I-67100 Laquila, Italy; Univ Paris 06, CNRS, LCMC, F-75252 Paris 05, France Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Consiglio Nazionale delle Ricerche (CNR); University of L'Aquila; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale per la Fisica della Materia (INFM-CNR); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS) Dormann, JL (corresponding author), Univ Versailles, CNRS, LMOV, F-78035 Versailles, France. García-Santiago, Antoni/L-9485-2014; D'Orazio, Franco/M-1905-2015 García-Santiago, Antoni/0000-0001-5757-5858; D'Orazio, Franco/0000-0002-1907-3125 BINDER K, 1986, REV MOD PHYS, V58, P801, DOI 10.1103/RevModPhys.58.801; Djurberg C, 1997, PHYS REV LETT, V79, P5154, DOI 10.1103/PhysRevLett.79.5154; Dormann JL, 1998, J MAGN MAGN MATER, V183, pL255, DOI 10.1016/S0304-8853(97)01123-2; Dormann JL, 1996, PHYS REV B, V53, P14291, DOI 10.1103/PhysRevB.53.14291; DORMANN JL, 1988, J PHYS C SOLID STATE, V21, P2015, DOI 10.1088/0022-3719/21/10/019; Dormann JL, 1997, ADV CHEM PHYS, V98, P283, DOI 10.1002/9780470141571.ch4; Dormann JL, 1997, MATER SCI FORUM, V235-2, P669, DOI 10.4028/www.scientific.net/MSF.235-238.669; Dormann JL, 1998, J MAGN MAGN MATER, V187, pL139, DOI 10.1016/S0304-8853(98)00135-8; Fischer K. H., 1991, SPIN GLASSES; Jonsson T, 1998, PHYS REV B, V57, P497, DOI 10.1103/PhysRevB.57.497; Mamiya H, 1998, PHYS REV LETT, V80, P177, DOI 10.1103/PhysRevLett.80.177; MEYER C, 1985, J MAGN MAGN MATER, V46, P254, DOI 10.1016/0304-8853(85)90044-7; Neel L., 1949, Ann. Geophys. (C.N.R.S.), V5, P99, DOI DOI 10.1016/S0009-2509(00)00427-9; TRONC E, 1995, HYPERFINE INTERACT, V95, P129, DOI 10.1007/BF02146310; TRONC E, 1992, N-HOLLAND D, P199; VAYSSIERES L, IN PRESS J COLLOID I 16 15 16 0 8 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0965-9773 NANOSTRUCT MATER Nanostruct. Mater. JUL 1999 12 5-8 B SI 757 762 10.1016/S0965-9773(99)00231-7 http://dx.doi.org/10.1016/S0965-9773(99)00231-7 6 Materials Science, Multidisciplinary Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S) Materials Science 224RN 2024-02-29 WOS:000081912200037 J Dorrance, HR; Oien, K; O'Dwyer, PJ Dorrance, HR; Oien, K; O'Dwyer, PJ Effects of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model SURGERY English Article ABDOMINAL-WALL METASTASES; ASSISTED COLECTOMY; SITE METASTASES; GALLBLADDER CANCER; SURGERY; ADENOCARCINOMA; RECURRENCE; COLON; LYMPHADENECTOMY; CHOLECYSTECTOMY Background and aims. Laparoscopic surgery for colorectal cancer is currently being evaluated in humans. The aim of this study was to examine the effect of laparoscopy on intraperitoneal tumor growth and distant metastases in an animal model. We also examined the effect of combining laparotomy with laparoscopy and on infusing the peritoneal cavity with normal saline solution (NaCl), crater; and sodium hypochlorite after laparoscopy on intraperitoneal tumor growth. Material and methods. Female Fischer rats were given MtLn3 adenocarcinoma cells by intraperitoneal injection to produce intraperitoneal tumor growth and by tail vein injection to produce lung metastases. A pneumoperitoneum was then induced to a pressure of 8 mm Hg with carbon dioxide (CO2), helium, or room air After this, animals were allowed to either recover or underwent laparotomy or infusion of NaCl, water, or sodium hypochlorite before recovery, depending on the experiment. At 21 days all animals were killed and intraperitoneal tumor growth was assessed by counting the number of peritoneal and serosal nodules and by weighing the omental pad of tumor Lung metastases were assessed by counting the number of metastases after fixation. Results. Laparoscopy caused a marked intraperitoneal dissemination of tumor with a median of 17 (10 to 20) peritoneal and serosal nodules for CO2, 19.5 (12.5 to 25) for helium, and 15.0 (9.9 to 1.77) for room air compared with 0 (0 to 1) for controls (P <.0001). The weight of omental tumor was also significantly increased (P <.02) in the CO2, helium, and room air groups. Infusion with NaCl, water, or sodium hypochlorite had no effect on tumor dissemination after laparoscopy. The combination of laparoscopy and laparotomy caused a significant reduction (P <.05) in the number of peritoneal nodules but had no significant effect on omental tumor growth. Laparoscopy also had no effect on the number of pulmonary metastases induced compared with controls. Conclusions. This study shows that laparoscopy promotes intraperitoneal dissemination of tumor. This effect is independent of the insufflating gas used and is not affected by use of a cytotoxic agent. The use of gasless laparoscopy should be encouraged by those undertaking curative laparoscopic surgery for colorectal cancer. Univ Glasgow, Western Infirm, Dept Surg, Glasgow G11 6NT, Lanark, Scotland; Univ Glasgow, Western Infirm, Dept Pathol, Glasgow G11 6NT, Lanark, Scotland University of Glasgow; University of Glasgow O'Dwyer, PJ (corresponding author), Univ Glasgow, Western Infirm, Dept Surg, Glasgow G11 6NT, Lanark, Scotland. Oien, Karin/AAH-3849-2019 ALLENDORF JDF, 1995, SURG ENDOSC-ULTRAS, V9, P49; BANGMA CH, 1995, J UROLOGY, V153, P1635, DOI 10.1016/S0022-5347(01)67484-6; BERENDS FJ, 1994, LANCET, V344, P58, DOI 10.1016/S0140-6736(94)91079-0; Bouvy ND, 1996, SURG ENDOSC-ULTRAS, V10, P490, DOI 10.1007/BF00188392; Bouvy ND, 1996, ANN SURG, V224, P694, DOI 10.1097/00000658-199612000-00005; CAVA A, 1990, EUR J SURG ONCOL, V16, P63; Champault G, 1997, BRIT J SURG, V84, P993, DOI 10.1002/bjs.1800840724; CIROCCO WC, 1994, SURGERY, V116, P842; CLAIR DG, 1993, SURGERY, V113, P355; DOCHERTY JG, 1995, BRIT J SURG, V82, P1050, DOI 10.1002/bjs.1800820816; DROUARD F, 1991, NEW ENGL J MED, V325, P1316; EGGERMONT AMM, 1988, CANCER DETECT PREV, V12, P421; FONG YM, 1993, ARCH SURG-CHICAGO, V128, P1054; FUSCO MA, 1993, DIS COLON RECTUM, V36, P858, DOI 10.1007/BF02047384; GRAY D, 1994, J SURG ONCOL, V57, P8, DOI 10.1002/jso.2930570104; HSIU JG, 1986, OBSTET GYNECOL, V68, pS90; HUBENS G, 1996, SURG ENDOSC-ULTRAS, V10, P181; HUGHES ESR, 1983, DIS COLON RECTUM, V26, P571, DOI 10.1007/BF02552962; Jacobi CA, 1997, SURGERY, V121, P72, DOI 10.1016/S0039-6060(97)90185-9; Jacobs M, 1991, Surg Laparosc Endosc, V1, P144; Jacquet P, 1995, Eur J Surg Oncol, V21, P568, DOI 10.1016/S0748-7983(95)97564-0; KNOLMAYER TJ, 1996, SURG ENDOSC, V10, P181; MILSOM JW, 1994, SURG ENDOSC-ULTRAS, V8, P1117, DOI 10.1007/BF00705735; MONSON JRT, 1992, LANCET, V340, P831, DOI 10.1016/0140-6736(92)92694-B; MONTORSI M, 1995, BRIT J SURG, V82, P1036, DOI 10.1002/bjs.1800820810; NDUKA CC, 1994, BRIT J SURG, V81, P648, DOI 10.1002/bjs.1800810506; NERI A, 1981, INT J CANCER, V28, P731, DOI 10.1002/ijc.2910280612; OROURKE N, 1993, LANCET, V342, P368, DOI 10.1016/0140-6736(93)91511-J; PHILLIPS EH, 1992, ANN SURG, V216, P703, DOI 10.1097/00000658-199212000-00015; PRASAD A, 1994, BRIT J SURG, V81, P1697, DOI 10.1002/bjs.1800811151; RAE D, 1995, BRIT J SURG, V82, P1142; Redwine D B, 1991, J Laparoendosc Surg, V1, P217, DOI 10.1089/lps.1991.1.217; STOCKDALE AD, 1985, EUR J SURG ONCOL, V11, P373; vanDijkum EJMN, 1996, BRIT J SURG, V83, P1793, DOI 10.1002/bjs.1800831242; Watson DI, 1997, ARCH SURG-CHICAGO, V132, P166; WEESE JL, 1986, SURGERY, V100, P273; WEXLER H, 1966, JNCI-J NATL CANCER I, V36, P641, DOI 10.1093/jnci/36.4.641; WEXNER SD, 1992, DIS COLON RECTUM, V35, P651, DOI 10.1007/BF02053755; WEXNER SD, 1995, BRIT J SURG, V82, P295, DOI 10.1002/bjs.1800820305 39 45 46 0 1 MOSBY-ELSEVIER NEW YORK 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA 0039-6060 SURGERY Surgery JUL 1999 126 1 35 40 10.1067/msy.1999.99056 http://dx.doi.org/10.1067/msy.1999.99056 6 Surgery Science Citation Index Expanded (SCI-EXPANDED) Surgery 219YP 10418590 Green Accepted 2024-02-29 WOS:000081636400007 J Doskey, PV; Fukui, Y; Sultan, M; Al Maghraby, A; Taher, A Doskey, PV; Fukui, Y; Sultan, M; Al Maghraby, A; Taher, A Source profiles for nonmethane organic compounds in the atmosphere of Cairo, Egypt JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION English Article CHEMICAL MASS-BALANCE; SOURCE-RECONCILIATION; CALCULATED REACTIVITIES; SOURCE FINGERPRINTS; VOLATILE ORGANICS; AIR-QUALITY; EMISSIONS; HYDROCARBONS; OZONE; APPORTIONMENT Profiles of the sources of nonmethane organic compounds (NMOCs) were developed for emissions from vehicles, petroleum fuels (gasoline, liquefied petroleum gas [LPG], and natural gas), a petroleum refinery, a smelter and a cast iron factory in Cairo, Egypt. More than 100 hydrocarbons and oxygenated hydrocarbons were tentatively identified and quantified. Gasoline-vapor and whole-gasoline profiles could be distinguished from the other profiles by high concentrations of the C-5 and C-6 saturated hydrocarbons. The vehicle emission profile was similar to the whole-gasoline profile, with the exception of the unsaturated and aromatic hydrocarbons, which were present at higher concentrations in the vehicle emission profile. High levels of the C-2-C-4 saturated hydrocarbons, particularly n-butane, were characteristic features of the petroleum refinery emissions. The smelter and cast iron factory emissions were similar to the refinery emissions; however, the levels of benzene and toluene were greater in the former two sources. The LPG and natural gas emissions contained high concentrations of n-butane and ethane, respectively. The NMOC source profiles for Cairo were distinctly different from profiles for U.S. sources, indicating that NMOC source profiles are sensitive to the particular composition of petroleum fuels that are used in a location. Argonne Natl Lab, Div Environm Res, Argonne, IL 60439 USA; Cairo Univ, Ctr Environm Hazard Mitigat, Giza, Egypt; Cairo Univ, Dept Geol, Giza, Egypt United States Department of Energy (DOE); Argonne National Laboratory; Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo University Doskey, PV (corresponding author), Argonne Natl Lab, Div Environm Res, 9700 S Cass Ave, Argonne, IL 60439 USA. Almaghraby, Abdallah/AAU-8541-2021 Almaghraby, Abdallah/0000-0001-6541-0850 ARONIAN PF, 1989, ATMOS ENVIRON, V23, P911, DOI 10.1016/0004-6981(89)90295-3; ATKINSON R, 1989, J PHYS CHEM REF DATA, V1; BLAKE DR, 1995, SCIENCE, V269, P953, DOI 10.1126/science.269.5226.953; CARTER WPL, 1994, J AIR WASTE MANAGE, V44, P881; CONNER TL, 1995, J AIR WASTE MANAGE, V45, P383, DOI 10.1080/10473289.1995.10467370; DOSKEY PV, 1992, J AIR WASTE MANAGE, V42, P1437, DOI 10.1080/10473289.1992.10467090; FUJITA EM, 1994, ENVIRON SCI TECHNOL, V28, P1633, DOI 10.1021/es00058a016; Fukui Y, 1996, J ENVIRON QUAL, V25, P601, DOI 10.2134/jeq1996.00472425002500030028x; Gertler AW, 1996, ATMOS ENVIRON, V30, P2297, DOI 10.1016/1352-2310(95)00090-9; HAMPTON CV, 1983, ENVIRON SCI TECHNOL, V17, P699, DOI 10.1021/es00118a003; HOEKMAN SK, 1992, ENVIRON SCI TECHNOL, V26, P1206, DOI 10.1021/es50002a610; KENSKI DM, 1995, J ENVIRON ENG-ASCE, V121, P483, DOI 10.1061/(ASCE)0733-9372(1995)121:7(483); Kirchstetter TW, 1996, ENVIRON SCI TECHNOL, V30, P661, DOI 10.1021/es950406p; LONNEMAN WA, 1986, ENVIRON SCI TECHNOL, V20, P790, DOI 10.1021/es00150a005; MAYRSOHN H, 1976, ATMOS ENVIRON, V10, P137, DOI 10.1016/0004-6981(76)90231-6; MAYRSOHN H, 1977, ATMOS ENVIRON, V11, P189, DOI 10.1016/0004-6981(77)90225-6; McLaren R, 1996, ATMOS ENVIRON, V30, P2219, DOI 10.1016/1352-2310(95)00178-6; McLaren R, 1996, ENVIRON SCI TECHNOL, V30, P3001, DOI 10.1021/es960036k; NELSON PF, 1983, ATMOS ENVIRON, V17, P439, DOI 10.1016/0004-6981(83)90117-8; OSHEA WJ, 1988, JAPCA J AIR WASTE MA, V38, P1020, DOI 10.1080/08940630.1988.10466443; PUJITA EM, 1995, ATMOS ENVIRON, V29, P3019; Rappaport S. M., 1987, APPL IND HYG, V2, P148, DOI 10.1080/08828032.1987.10390542; Sagebiel JC, 1996, ATMOS ENVIRON, V30, P2287, DOI 10.1016/1352-2310(95)00117-4; SCANION JT, 1985, J CHROMATOGR SCI, V23, P333, DOI 10.1093/chromsci/23.8.333; Scheff PA, 1996, J AIR WASTE MANAGE, V46, P1048, DOI 10.1080/10473289.1996.10467540; SCHEFF PA, 1989, JAPCA J AIR WASTE MA, V39, P469, DOI 10.1080/08940630.1989.10466546; SEXTON K, 1983, ATMOS ENVIRON, V17, P467, DOI 10.1016/0004-6981(83)90120-8; SIGSBY JE, 1987, ENVIRON SCI TECHNOL, V21, P466, DOI 10.1021/es00159a007; WADDEN RA, 1986, ENVIRON SCI TECHNOL, V20, P473, DOI 10.1021/es00147a006 29 34 37 0 18 AIR & WASTE MANAGEMENT ASSOC PITTSBURGH ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA 1047-3289 J AIR WASTE MANAGE J. Air Waste Manage. Assoc. JUL 1999 49 7 814 822 10.1080/10473289.1999.10463850 http://dx.doi.org/10.1080/10473289.1999.10463850 9 Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences Science Citation Index Expanded (SCI-EXPANDED) Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences 218ZR 28060656 2024-02-29 WOS:000081582900007 J Dou, WB; Sun, ZL Dou, WB; Sun, ZL Comparison of diffraction fields of lens by two calculation formulas INTERNATIONAL JOURNAL OF INFRARED AND MILLIMETER WAVES English Article millimeter waves; imaging; diffraction fields Diffraction fields in the focal space of some lens is investigated by using ray tracing and Stratton-Chu formulas. Two formulas are used. One is surface integration formula, and for another a line integration is added. Comparison of two calculation results is given. It is shown that for hyperbolic lens two calculations results are same and for extended hemi-ellipsoidal lens there are a lilt difference between them. Southeast Univ, Dept Radio Engn, State Key Lab Millimeter Waves, Nanjing 210096, Peoples R China Southeast University - China Dou, WB (corresponding author), Southeast Univ, Dept Radio Engn, State Key Lab Millimeter Waves, Nanjing 210096, Peoples R China. Dou WB, 1998, J ELECTROMAGNET WAVE, V12, P1575, DOI 10.1163/156939398X00494; MIZUNO K, 1998, 23 INT C INFR MILL W, P1; SILVER S, 1984, IEE SERIES ELECTROMA, V19; Solimeno S., 1986, Guiding, Diffraction and Confinement of Optical Radiation 4 0 0 0 1 KLUWER ACADEMIC/PLENUM PUBL NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 0195-9271 INT J INFRARED MILLI Int. J. Infrared Millimeter Waves JUL 1999 20 7 1307 1315 10.1023/A:1021766626289 http://dx.doi.org/10.1023/A:1021766626289 9 Engineering, Electrical & Electronic; Optics; Physics, Applied Science Citation Index Expanded (SCI-EXPANDED) Engineering; Optics; Physics 216EU 2024-02-29 WOS:000081429000007 J Douglas, MR; Mallonee, S; Istre, GR Douglas, MR; Mallonee, S; Istre, GR Estimating the proportion of homes with functioning smoke alarms: A comparison of telephone survey and household survey results AMERICAN JOURNAL OF PUBLIC HEALTH English Article RESIDENTIAL-FIRE INJURIES; RISK-FACTORS; HEALTH; SURVEILLANCE Administering questionnaires by telephone has become an increasingly acceptable and widely used means of doing health research.(1) Telephone surveys have many advantages over in-person surveys. They are usually less expensive,(1-5) and they minimize sampling error when the sample is drawn from random-digit dialing.(1,6,7) Telephone surveys allow for timely data collection for states and subgroups of the population.(2-4,8) The main disadvantage of telephone surveys has been the potential for sampling bias(2,9) and variable estimates of behavioral factors caused by excluding households not accessible by telephone. According to the US census, 95% of US households and 91% of Oklahoma households had telephones in 1990. To determine the proportion of households with functioning smoke alarms in a low-income area of Oklahoma City with a high rate of residential fire-related injuries,(10) we conducted a targeted random telephone survey; to validate the telephone survey, we conducted a retrospective random household survey. The purpose of the survey was to establish a baseline rate for use in evaluating a large smoke-alarm giveaway program in this high-risk area. Oklahoma State Dept Hlth, Injury Prevent Serv, Oklahoma City, OK 73117 USA; Greater Dallas Injury Prevent Ctr, Dallas, TX USA; Pediat Crit Care Associates, Dallas, TX USA Mallonee, S (corresponding author), Oklahoma State Dept Hlth, Injury Prevent Serv, 0307,1000 NE 10th St, Oklahoma City, OK 73117 USA. PHS HHS [R49/CCR603696] Funding Source: Medline PHS HHS(United States Department of Health & Human ServicesUnited States Public Health Service) [Anonymous], 1992, Morbidity and mortality weekly report; BALLARD JE, 1992, AM J EPIDEMIOL, V135, P26, DOI 10.1093/oxfordjournals.aje.a116198; BRAMBILLA DJ, 1987, AM J EPIDEMIOL, V126, P962, DOI 10.1093/oxfordjournals.aje.a114734; Cannell C. F., 1965, VITAL HLTH STAT, V2; COREY CR, 1990, HEALTH SERV RES, V25, P129; *CTR DIS CONTR PRE, 1994, EPI INF COMP PROGR V; FOX TA, 1992, J AM DIET ASSOC, V92, P729; Kahn HA., 1989, STAT METHODS EPIDEMI; LOCANDER W, 1976, J AM STAT ASSOC, V71, P269, DOI 10.2307/2285297; Mallonee S, 1996, NEW ENGL J MED, V335, P27, DOI 10.1056/NEJM199607043350106; MARCUS AC, 1986, MED CARE, V24, P97, DOI 10.1097/00005650-198602000-00002; MARIN G, 1990, AM J PUBLIC HEALTH, V80, P323, DOI 10.2105/AJPH.80.3.323; *NAT FIR PROT ASS, 1996, GUID IMPL FIR PREV W; NEBOT M, 1994, J EPIDEMIOL COMMUN H, V48, P412, DOI 10.1136/jech.48.4.412; POTTHOFF RF, 1994, AM J EPIDEMIOL, V139, P967, DOI 10.1093/oxfordjournals.aje.a116946; REMINGTON PL, 1988, PUBLIC HEALTH REP, V103, P366; RUNYAN CW, 1992, NEW ENGL J MED, V327, P859, DOI 10.1056/NEJM199209173271207; SIEMIATYCKI J, 1979, AM J PUBLIC HEALTH, V69, P238, DOI 10.2105/AJPH.69.3.238; Smith C.L., 1993, SMOKE DETECTOR OPERA; WEEKS MF, 1983, AM J PUBLIC HEALTH, V73, P1389, DOI 10.2105/AJPH.73.12.1389 20 33 34 0 1 AMER PUBLIC HEALTH ASSOC INC WASHINGTON 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 USA 0090-0036 AM J PUBLIC HEALTH Am. J. Public Health JUL 1999 89 7 1112 1114 10.2105/AJPH.89.7.1112 http://dx.doi.org/10.2105/AJPH.89.7.1112 3 Public, Environmental & Occupational Health Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) Public, Environmental & Occupational Health 209QG 10394329 Green Published, Bronze 2024-02-29 WOS:000081059100027 J Dover, JS Dover, JS In my hands ... - Response DERMATOLOGIC SURGERY English Letter 0 0 0 0 0 BLACKWELL SCIENCE INC MALDEN 350 MAIN ST, MALDEN, MA 02148 USA 1076-0512 DERMATOL SURG Dermatol. Surg. JUL 1999 25 7 593 593 1 Dermatology; Surgery Science Citation Index Expanded (SCI-EXPANDED) Dermatology; Surgery 219XD 2024-02-29 WOS:000081632800027 J Dowd, S Dowd, S The integration of intellectual property (IP) for a system ASIC ELECTRONIC ENGINEERING English Article IP and design re-use are now accepted solutions to the problems of design productivity for today's deep sub micron (DSM), multi-million gate system level ASIC designs. Physical implementation of system ASIC designs can no longer be considered aback-end task to the design process; the old serial demarcation between front and back-end is no longer acceptable. This article presents the system design methodology for a system level ASIC design for, set top box which has been successfully implemented on 0.35 mu m embedded array Fujitsu ASIC technology. Fujitsu Microelect, European ASIC Design Grp, San Jose, CA 95134 USA Fujitsu Ltd Dowd, S (corresponding author), Fujitsu Microelect, European ASIC Design Grp, San Jose, CA 95134 USA. 0 0 0 0 0 MILLER FREEMAN TECHNICAL LTD LONDON 30 CALDERWOOD ST, LONDON, ENGLAND SE18 6QH 0013-4902 ELECTRON ENG Electron. Eng. JUL 1999 71 870 25 + 4 Engineering, Electrical & Electronic Science Citation Index Expanded (SCI-EXPANDED) Engineering 228AU 2024-02-29 WOS:000082114000007 J Dowker, JS; Kirsten, K Dowker, JS; Kirsten, K Spinors and forms on the ball and the generalized cone COMMUNICATIONS IN ANALYSIS AND GEOMETRY English Article ANTISYMMETRIC TENSOR-FIELDS; HEAT-KERNEL COEFFICIENTS; D-DIMENSIONAL BALL; ZETA-FUNCTION; LAPLACE OPERATOR; BOUNDARY-CONDITIONS; SPECTRAL GEOMETRY; LENS SPACES; DETERMINANTS; TORSION A method is presented, and used, for determining any heat-kernel coefficient for the form-valued Laplacian on the D-ball as an explicit function of dimension and form order. The calculation is offerred as a particular application of a general technique developed earlier for obtaining heat-kernel coefficients on a bounded generalized cone which involves writing the sphere and ball xi-functions, and coefficients, in terms of Barnes xi-functions and generalized Bernoulli polynomials. Functional determinants are computed. Spinors are also treated by the general method. Univ Manchester, Dept Theoret Phys, Manchester M13 9PL, Lancs, England; Univ Leipzig, Inst Theoret Sci, D-04109 Leipzig, Germany University of Manchester; Leipzig University Dowker, JS (corresponding author), Univ Manchester, Dept Theoret Phys, Manchester M13 9PL, Lancs, England. Barnes E., 1904, T CAMBRIDGE PHILOS S, V19, P374; Barnes E. 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Adv. Math., V2nd; IKEDA A, 1978, OSAKA J MATH, V15, P515; IWASAKI I, 1979, P JPN ACAD A-MATH, V55, P141, DOI 10.3792/pjaa.55.141; Kirsten K, 1996, CLASSICAL QUANT GRAV, V13, P633, DOI 10.1088/0264-9381/13/4/005; Levitin M, 1998, DIFFER GEOM APPL, V8, P35, DOI 10.1016/S0926-2245(97)00016-8; MOSS IG, 1994, PHYS LETT B, V333, P326, DOI 10.1016/0370-2693(94)90150-3; NASH C, 1995, J MATH PHYS, V36, P1462, DOI 10.1063/1.531134; NORLUND NE, 1921, ACTA MATH, V4, P1922; RAY DB, 1970, ADV MATH, V4, P109, DOI 10.1016/0001-8708(70)90018-6; RUSSELL IH, 1986, CLASSICAL QUANT GRAV, V4, P1357; VOROS A, 1987, COMMUN MATH PHYS, V110, P439, DOI 10.1007/BF01212422; [No title captured] 37 24 24 0 2 INT PRESS CO LTD IRVINE UNIV CALIFORNIA, IRVINE, DEPT MATHEMATICS, IRVINE, CA 92697-3875 USA 1019-8385 COMMUN ANAL GEOM Commun. Anal. Geom. JUL 1999 7 3 641 679 10.4310/CAG.1999.v7.n3.a7 http://dx.doi.org/10.4310/CAG.1999.v7.n3.a7 39 Mathematics Science Citation Index Expanded (SCI-EXPANDED) Mathematics 283KG Bronze 2024-02-29 WOS:000085274300007 J Downing, JA; McClain, M; Twilley, R; Melack, JM; Elser, J; Rabalais, NN; Lewis, WM; Turner, RE; Corredor, J; Soto, D; Yanez-Arancibia, A; Kopaska, JA; Howarth, RW Downing, JA; McClain, M; Twilley, R; Melack, JM; Elser, J; Rabalais, NN; Lewis, WM; Turner, RE; Corredor, J; Soto, D; Yanez-Arancibia, A; Kopaska, JA; Howarth, RW The impact of accelerating land-use change on the N-cycle of tropical aquatic ecosystems: Current conditions and projected changes BIOGEOCHEMISTRY English Review estuaries; lakes; marine; nitrogen; phosphorus; rivers; streams; temperate; tropics CENTRAL AMAZON BASIN; PHYTOPLANKTON NUTRIENT LIMITATION; RAIN-FOREST CATCHMENT; NORTH-ATLANTIC OCEAN; MAJOR IONIC SOLUTES; LOWER PARANA RIVER; NITROGEN LIMITATION; MARINE-ENVIRONMENT; FLOODPLAIN LAKE; ATMOSPHERIC DEPOSITION Published data and analyses from temperate and tropical aquatic systems are used to summarize knowledge about the potential impact of land-use alteration on the nitrogen biogeochemistry of tropical aquatic ecosystems, identify important patterns and recommend key needs for research. The tropical N-cycle is traced from pre-disturbance conditions through the phases of disturbance, highlighting major differences between tropical and temperate systems that might influence development strategies in the tropics. Analyses suggest that tropical freshwaters are more frequently N-limited than temperate zones, while tropical marine systems may show more frequent P limitation. These analyses indicate that disturbances to pristine tropical lands will lead to greatly increased primary production in freshwaters and large changes in tropical freshwater communities. Increased freshwater nutrient flux will also lead to an expansion of the high production, N- and light-limited zones around river deltas, a switch from P- to N-limitation in calcareous marine systems, with large changes in the community composition of fragile mangrove and reef systems. Key information gaps are highlighted, including data on mechanisms of nutrient transport and atmospheric deposition in the tropics, nutrient and material retention capacities of tropical impoundments, and N/P coupling and stoichiometric impacts of nutrient supplies on tropical aquatic communities. The current base of biogeochemical data suggests that alterations in the N-cycle will have greater impacts on tropical aquatic ecosystems than those already observed in the temperate zone. Iowa State Univ, Dept Anim Ecol, Ames, IA 50011 USA; Univ Miami, RSMAS, MGG, Miami, FL USA; Univ SW Louisiana, Dept Biol, Lafayette, LA 70504 USA; Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA USA; Arizona State Univ, Dept Zool, Tempe, AZ 85287 USA; Louisiana Univ Marine Consortium, Chauvin, LA USA; Univ Colorado, Cooperat Inst Res Environm Sci, Ctr Limnol, Boulder, CO USA; Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA; Univ Puerto Rico, Dept Marine Sci, Mayaguez, PR 00709 USA; Univ Austral Chile, Inst Ciencias Nat & Exactas, Fac Pesquierias & Oceanog, Puerto Montt, Chile; Inst Ecol AC, Dept Coastal Resources, Xalapa, Veracruz, Mexico; Cornell Univ, Ecol & Systemat Sect, Ithaca, NY 14853 USA Iowa State University; University of Miami; University of Louisiana Lafayette; University of California System; University of California Santa Barbara; Arizona State University; Arizona State University-Tempe; University of Colorado System; University of Colorado Boulder; Louisiana State University System; Louisiana State University; University of Puerto Rico; University of Puerto Rico Mayaguez; Universidad Austral de Chile; Instituto de Ecologia - Mexico; Cornell University Downing, JA (corresponding author), Iowa State Univ, Dept Anim Ecol, Ames, IA 50011 USA. 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J. Anaesth.-J. Can. Anesth. JUL 1999 46 7 704 706 10.1007/BF03013964 http://dx.doi.org/10.1007/BF03013964 3 Anesthesiology Science Citation Index Expanded (SCI-EXPANDED) Anesthesiology 215DP Bronze 2024-02-29 WOS:000081366900017 J Doyle, V; Virji, S; Crompton, M Doyle, V; Virji, S; Crompton, M Evidence that cyclophilin-A protects cells against oxidative stress BIOCHEMICAL JOURNAL English Article antisense oligodeoxynucleotides; cardiomyocytes; cyclosporin A MITOCHONDRIAL PERMEABILITY TRANSITION; CYCLOSPORINE-A; MESSENGER-RNA; INORGANIC-PHOSPHATE; REPERFUSION INJURY; INDUCED DAMAGE; PORE; HEPATOCYTES; INVOLVEMENT; CLONING Cyclophilin-A is the cytosolic isoform of a family of peptidyl-proline cis-rr uns-isomerases that bind cyclosporin A. This study investigates the role of cyclophilin-A in necrotic cell death, induced by chemical ischaemia and by t-butylhydroperoxide. An 18-mer antisense phosphorothioate oligodeoxynucleotide was used to target a translated region of cyclophilin-a mRNA in rat neonatal cardiomyocytes. After a 24 h exposure to the oligonucleotide, the amount of cyclophilin-A in the cells was decreased by at least 93% as judged bq immunological and enzymic criteria. For the enzyme assays, peptidyl proline cis-trans-isomerase activity was measured fluorimetrically in small (10 mu l) volumes of cell extract. Immunoblots were developed with a polyclonal anti-cyclophilin-A antibody after sample isoelectric focusing and SDS/PAGE. Cyclophilin-A suppression had no effect on cyanide-plus-3-deoxyglucose-induced cell death. However, cyclophilin-A-suppressed cells were markedly more sensitive to t-butylhydroperoxide. Cyclosporin A conferred some resistance to the peroxide in both types of cell, bur protection was greater in cyclophilin-A-suppressed cells, where cyclosporin A increased the survival time 2-fold. It is concluded that two cyclophilin isoforms are involved, in quite different ways, in peroxide-induced cell death. Cyclophilin-A has a protective role. Another isoform, possibly mitochondrial cyclophilin-D, has a deleterious cole, such that blockade by cyclosporin A leads to protection. 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J. JUL 1 1999 341 1 127 132 10.1042/0264-6021:3410127 http://dx.doi.org/10.1042/0264-6021:3410127 6 Biochemistry & Molecular Biology Science Citation Index Expanded (SCI-EXPANDED) Biochemistry & Molecular Biology 216XB 10377253 Green Published 2024-02-29 WOS:000081468800017 J Doyle, W; Crawley, H; Robert, H; Bates, CJ Doyle, W; Crawley, H; Robert, H; Bates, CJ Iron deficiency in older people: Interactions between food and nutrient intakes with biochemical measures of iron; further analysis of the National Diet and Nutrition Survey of people aged 65 years and over EUROPEAN JOURNAL OF CLINICAL NUTRITION English Article elderly; iron status; nutrient intake; food consumption CALCIUM INTAKE; ABSORPTION; IMMUNITY; DISEASE; BRAIN Objective: To quantitatively investigate relationships between food consumption, nutrient intake and biochemical markers of iron status in a population of older people. Design: National Diet and Nutrition Survey: cross-sectional survey of a nationally representative population of men and women aged 65y and over. Setting: Mainland Great Britain Subjects: 1268 participants (651 men and 617 women) who provided both dietary intake and blood biochemistry. 986 were living in private households and 282 were living in residential or nursing homes. Results: Intakes of alcohol, vitamin C, protein, haem and non-haem iron and fibre were positively associated with iron status. Consumption of meat, poultry and fish were positively associated with six measures of iron status, and vegetables and potatoes with four measures. Calcium, dairy foods and tea generally had a negative association with most measures of iron status. Conclusions: A varied diet containing meat, poultry and fish, vegetables and fruit, with a moderate intake of alcohol will make a positive contribution to the iron status of elderly people. Univ N London, Inst Brain Chem & Human Nutr, London E9 6QU, England; Univ N London, Sch Math Sci, London N7 6DB, England; MRC, Dunn Nutr Lab, Cambridge CB4 1XJ, England London Metropolitan University; London Metropolitan University Doyle, W (corresponding author), Univ N London, Inst Brain Chem & Human Nutr, 189 Well St, London E9 6QU, England. 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Clinically, the lesion resembled periapical pathosis of odontogenic origin. The clinical and histopathologic features of cemento-osseous dysplasia are reviewed. Univ Belgrade, Clin Oral Surg, Fac Stomatol, YU-11000 Belgrade, Yugoslavia University of Belgrade Drazic, R (corresponding author), Univ Belgrade, Clin Oral Surg, Fac Stomatol, Dr Subot 4, YU-11000 Belgrade, Yugoslavia. EVERSOLE LR, 1984, ORAL SURG ORAL MED O, V58, P456, DOI 10.1016/0030-4220(84)90344-X; Slootweg PJ, 1996, SEMIN DIAGN PATHOL, V13, P104; SUMMERLIN DJ, 1994, ORAL SURG ORAL MED O, V78, P611, DOI 10.1016/0030-4220(94)90174-0; WALDRON CA, 1993, J ORAL MAXIL SURG, V51, P828, DOI 10.1016/S0278-2391(10)80097-7; WALDRON CA, 1995, ORAL MAXILLOFACIAL P, P444 5 13 13 0 1 MOSBY-ELSEVIER NEW YORK 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA 1079-2104 1528-395X ORAL SURG ORAL MED O Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 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Differentiation induction is a new approach taking into account that malignant glioma cells share many features with immature glial progenitor cells that are capable of terminal differentiation. The concept of differentiation therapy is currently evaluated for several pediatric malignancies with or without multimodal standard therapy. Valproic acid (VPA) is a branched chain fatty acid that is able to inhibit proliferation of neuroectodermal cells and to induce these cells along neuronal or glial lineage. Preclinical studies have shown that VPA inhibits growth of human and rodent glial tumor cells in vitro and induces a distinct mature glial phenotype, In addition, growth of human neuroblastoma cells is inhibited in vitro and in vivo and exhibits marked evidence of differentiation. Treatment of neuroblastoma and glioma cells with VPA was accompanied by changes of surface molecule expression that enhance immunogenicity and reduce their capability to metastasize. The antitumoral effects observed in preclinical studies were reached at concentrations that are readily achieved in patients treated with VPA for epilepsy. Epilepsy patients receiving VPA have significantly enhanced hemoglobin F levels, supporting the hypothesis that nontoxic levels of VPA can induce cellular differentiation. Broad clinical experience with VPA and its low toxicity encourage the evaluation of VPA in patients that have been submitted to postoperative combined chemo- and radiotherapy for pediatric malignant glioma. 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Dnepropetrovsk State Univ, Dnepropetrovsk, Ukraine Ministry of Education & Science of Ukraine; Oles Honchar Dnipro National University Drobakhin, OO (corresponding author), Dnepropetrovsk State Univ, Dnepropetrovsk, Ukraine. Drobakhin, Oleg O/U-9647-2017; drobakhin, oleg/D-3936-2016 drobakhin, oleg/0000-0003-2624-9122 AKHMETSHIN AM, 1984, DEFEKTOSKOPIYA, P84; APLETALIN VN, 1991, IZMER TEKH, P40; BARTASHEVSKII EL, 1991, DEFEKTOSKOPIYA, P86; BORULKO VF, 1986, DEFEKTOSKOPIYA, P36; BORULKO VF, 1993, DEFEKTOSKOPIYA, P70; BORULKO VF, 1993, DEFECTOSKOPIYA, P65; DROBAKHIN OO, Patent No. 1485150; DROBAKHIN OO, 1984, DEFEKTOSKOPIYA, P19; DROBAKHIN OO, 1999, DEFECTOSKOPIYA, P37; Ginzburg V. M., 1981, Holographic measurements 10 0 0 0 0 PLENUM PUBL CORP NEW YORK CONSULTANTS BUREAU, 233 SPRING ST, NEW YORK, NY 10013 USA 1061-8309 RUSS J NONDESTRUCT+ Russ. J. Nondestr. Test. JUL 1999 35 7 545 551 7 Materials Science, Characterization & Testing Science Citation Index Expanded (SCI-EXPANDED) Materials Science 264ET 2024-02-29 WOS:000084168200007 J Droste, C; Starosta, K; Wierzchucka, A; Morek, T; Rohozinski, SG; Srebrny, J; Bergström, M; Herskind, B; Wesolowski, E Droste, C; Starosta, K; Wierzchucka, A; Morek, T; Rohozinski, SG; Srebrny, J; Bergström, M; Herskind, B; Wesolowski, E PPCO:: polarization-polarization correlation from oriented nuclei NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT English Article linear polarization of gamma radiation; polarization-polarization angular correlation; multidetector arrays for gamma-ray spectroscopy DIRECTIONAL CORRELATION; COMPTON POLARIMETERS The correlation between linear polarization of one gamma-ray quantum and polarization of the next gamma-ray quantum emitted in a cascade from an oriented nucleus is discussed. This correlation forms the basis for developing the PPCO method which, in principle, can determine spins, parities and multipolarities. The method is particularly useful when gamma rays are produced in heavy ion reactions, ensuring a high spin alignment. The paper presents an experimental test of the PPCO method and the results suggest, that this method can be applied with success in modern gamma-ray spectroscopy in which a large number of detectors are sensitive to the polarization (e.g. the CLOVER detectors). When this method is combined with an angular correlation analysis, the number of the possibilities concerning spins, parities and multipolarity sequences can be reduced significantly. (C) 1999 Elsevier Science B.V. All rights reserved. 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ANNALS OF BOTANY English Article 3D plant architecture; horizontal gradients in leaf nitrogen; leaf irradiance; leaf nitrogen content per unit area; maize; nitrogen partitioning; nitrogen remobilization; virtual plant; Zea mays L. LUCERNE CANOPY; USE EFFICIENCY; CARBON GAIN; C-3 PLANTS; PHOTOSYNTHESIS; LEAVES; RADIATION; DENSITY; AGE; ACCLIMATION Numerous studies have dealt with the relationship between leaf nitrogen content and leaf irradiance. However, most of them refer to dense stands presenting reduced horizontal heterogeneity of foliage distribution. Both gradients of leaf nitrogen and leaf irradiance related to canopy depth are significant under such conditions, and modelling radiative exchange using a turbid-medium analogy and dividing the canopy into vegetation layers is sufficient. Conversely, row crops such as maize are characterized by strong horizontal heterogeneity of foliage distribution and the one-dimensional (1D) approach may be unsuitable. We thus modelled the three-dimensional (3D) geometry of maize canopies with varying densities and at different developmental stages using plant digitizing under field conditions. The nitrogen content per unit area of each leaf part was obtained subsequently by nitrogen analysis. We next calculated radiative exchange using a 3D volume-based approach within the canopies in order to estimate local leaf irradiance on a daily integration scale. Vertical gradients in leaf nitrogen content per unit area observed in dense stands during the vegetative phase corresponded largely to those reported in the literature. We also identified significant gradients in nitrogen content along the leaves, which had not before been clearly demonstrated. Our study shows that local light climate during plant development plays a major role in leaf nitrogen distribution and remobilization. Moreover, brutal plant thinning involves rapid changes in leaf nitrogen partitioning. 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Bot. JUL 1999 84 1 61 69 10.1006/anbo.1999.0890 http://dx.doi.org/10.1006/anbo.1999.0890 9 Plant Sciences Science Citation Index Expanded (SCI-EXPANDED) Plant Sciences 213QA Bronze 2024-02-29 WOS:000081283700007 J Druhan, JP; Wilent, WB Druhan, JP; Wilent, WB Effects of the competitive N-methyl-D-aspartate receptor antagonist, CPP, on the development and expression of conditioned hyperactivity and sensitization induced by cocaine BEHAVIOURAL BRAIN RESEARCH English Article N-methyl-D-aspartate; cocaine; excitatory amino acid AMPHETAMINE BEHAVIORAL SENSITIZATION; RAT-BRAIN MEMBRANES; CHANNEL COMPLEX; OPEN-FIELD; STRESS; NMDA; MK-801; ACQUISITION; LOCOMOTOR; AMYGDALA This study used novel behavioral measures to examine the effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist, CPP, on the development and expression of conditioned hyperactivity and sensitization produced with cocaine. The first experiment confirmed that horizontal locomotor activity measured in the central zone of an activity enclosure could be increased by 10.0 mg/kg cocaine. This increased activity showed sensitization after repeated cocaine injections, and it could be conditioned to the test environment. Subsequent experiments demonstrated that CPP (0.2 and 0.4 nmol, icv) could block the development, but not the expression, of conditioned hyperactivity and sensitization in the central zone. These findings confirm that NMDA receptors are critically involved in the development of conditioned hyperactivity and sensitization, but indicate that such receptors may not be necessary for the expression of these neurobehavioral adaptations. (C) 1999 Elsevier Science B.V. All rights reserved. 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JUL 1999 102 1-2 195 210 10.1016/S0166-4328(99)00017-0 http://dx.doi.org/10.1016/S0166-4328(99)00017-0 16 Behavioral Sciences; Neurosciences Science Citation Index Expanded (SCI-EXPANDED) Behavioral Sciences; Neurosciences & Neurology 214HV 10403027 hybrid 2024-02-29 WOS:000081323300017 J Du, ZY; Gromet-Elhanan, Z Du, ZY; Gromet-Elhanan, Z Refolding of recombinant α and β subunits of the Rhodospirillum rubrum F0F1 ATP synthase into functional monomers that reconstitute an active α1β1-dimer EUROPEAN JOURNAL OF BIOCHEMISTRY English Article assembly of active alpha(1)beta(1)-dimers; ATP synthase; F-1-ATPase; refolding of functional alpha and beta monomers; Rhodospirillum rubrum THERMOPHILIC BACTERIUM PS3; ESCHERICHIA-COLI; ALPHA-3-BETA-3 COMPLEX; OVER-EXPRESSION; CATALYTIC CORE; CHLOROPLAST; F1-ATPASE; ROTATION; SEQUENCE; BINDING The alpha subunit from the Rhodospirillum rubrum F0F1 ATP synthase (RrF(1)alpha) was over-expressed in une operon-deleted Escherichia coli strains under various growth conditions only in insoluble inclusion bodies, The functional refolding of urea-solubilized RrF(1)alpha was followed by measuring its ability to stimulate the restoration of ATP synthesis and hydrolysis in beta-less R. rubrum chromatophores reconstituted with pure native or recombinant RrF(1)beta [Nathanson, L,. & Gromet-Elhanan, Z. (1998) J. Biol. Chem. 273, 10933-10938]. The refolding efficiency was found to increase with decreasing RrF(1)alpha concentrations and required high concentrations of MgATP, saturating approximate to 60% when 50 mu g protein.mL(-1) were refolded in presence of 50 mM MgATP. Size-exclusion HPLC of such refolded RrF(1)alpha revealed a 50-60% decrease in its aggregated form and a parallel appearance of its monomeric peak. RrF(1)beta refolded under identical conditions appeared almost exclusively as a monomer. This procedure enabled the isolation of large amounts of a stable RrF(1)alpha monomer, which stimulated the restoration of ATP synthesis and hydrolysis much more efficiently than the refolded cu mixture, and bound ATP and ADP in a Mg-dependent manner. Incubation of both RrF(1)alpha and beta monomers, which by themselves had no ATPase activity, resulted in a parallel appearance of activity and assembled alpha(1)beta(1)-dimers, but showed no formation of alpha(3)beta(3)-hexamers. The RrF(1)-alpha(1)beta(1)-ATPase activity was, however, very similar to the activity observed in isolated native chloroplast CF1-alpha(3)beta(3), indicating that these dimers contain only the catalytic nucleotide-binding site at their alpha/beta interface. Their inability to associate into an alpha(3)beta(3)-hexamer seems therefore to. reflect a much lower stability of the noncatalytic RrF(1) alpha/beta interface. 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JUL 1999 20 3 223 225 3 Environmental Sciences Science Citation Index Expanded (SCI-EXPANDED) Environmental Sciences & Ecology 240QN 2024-02-29 WOS:000082836800007 J Dubey, SP; Garap, JP Dubey, SP; Garap, JP Paediatric tracheostomy: an analysis of 40 cases JOURNAL OF LARYNGOLOGY AND OTOLOGY English Article tracheostomy; child; post-operative complications PEDIATRIC TRACHEOTOMY Tracheostomy in the paediatric patient has been associated with significant morbidity and mortality compared to that in the adult. A retrospective analysis was made of 40 patients up to the age of 12 years having tracheostomies. Upper airway obstruction made up the commonest (32 patients, or 80 per cent) indication for paediatric tracheostomy in our series where males slightly outnumbered females. The majority (31 patients, or 77.5 per cent) underwent the operation under general anaesthesia with endotracheal intubation. Thirty-four (85 per cent) patients underwent 'planned' tracheostomies and six (15 per cent) underwent 'crash' procedures. Thirteen (32.5 per cent) patients were under the age of one year when tracheostomies were performed. The maximum duration of tracheostomies was between one week to within a month and after one month to within three months; each containing 11 (27.5 per cent) patients. Sixty-four different surgical procedures were performed on these patients in which laryngoscopy and bronchoscopy were the commonest procedures. Nine (22.5 per cent) had early post-operative and 14 (35 per cent) had late post-operative complications. Among these 40 children with tracheostomies, one (2.5 per cent) died due to a tracheostomy-related cause and 10 (25 per cent) due to the primary disease process itself. Tracheostomies performed to provide access for general anaesthesia for other surgical procedures were associated with a better prognosis. 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Laryngol. Otol. JUL 1999 113 7 645 651 10.1017/S0022215100144743 http://dx.doi.org/10.1017/S0022215100144743 7 Otorhinolaryngology Science Citation Index Expanded (SCI-EXPANDED) Otorhinolaryngology 216TE 10605562 2024-02-29 WOS:000081458900007 J Dubois, S; Piraux, L; George, JM; Ounadjela, K; Duvail, JL; Fert, A Dubois, S; Piraux, L; George, JM; Ounadjela, K; Duvail, JL; Fert, A Evidence for a short spin diffusion length in permalloy from the giant magnetoresistance of multilayered nanowires PHYSICAL REVIEW B English Article PERPENDICULAR MAGNETORESISTANCE; MAGNETIC MULTILAYERS; AG/CO MULTILAYERS; CO/CU NANOWIRES; TRANSPORT; MEMBRANE; NIFE/CU; SWITCH We present magnetization and giant magnetoresistance (GMR) measurements performed on two series of electrodeposited Py/Cu multilayered nanowires (Py = Ni80Fe20) of diameter null set =90 nm. The multilayers of the first series are composed of a conventional stacking of Py and Cu layers and the GMR is studied as a function of the Cu thickness for a constant Py thickness. The multilayers of the second series are composed of Py/Cu/Py trilayers uniformly distributed along the filament and separated from each other by thick Cu layers. For this second series, magnetic and GMR properties were investigated as a function of the Py layer thickness and our magnetization measurements demonstrate that, for Py layers thinner than about 90 nm, the magnetic moments of the two Py layers of a trilayer are approximately antiparallel at zero field. Analysis of the GMR data using the Valet-Fert model allows us to estimate that the spin diffusion length in Py, L-sf((PY)) , is between 3.3 and 5.3 nm. [S0163-1829(99)06125-1]. Unite Phys Chim & Phys Mat, B-1348 Louvain, Belgium; CNRS, LCR Thomson, Unite Mixte Rech Thomson, F-91404 Orsay, France; Univ Paris 11, F-91405 Orsay, France; Inst Phys & Chim Mat Strasbourg, F-67037 Strasbourg, France; Unite Phys Chim & Phys Mat, B-1348 Louvain, Belgium Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg Dubois, S (corresponding author), Unite Phys Chim & Phys Mat, Pl Croix Sud 1, B-1348 Louvain, Belgium. Duvail, Jean-Luc/B-4635-2009; Sylvain, DUBOIS/A-4724-2013; Duvail, Jean-Luc/K-4438-2015 Sylvain, DUBOIS/0000-0003-1881-7185; Duvail, Jean-Luc/0000-0002-8929-9365 BASS J, IN PRESS COMMENTS CO; BLONDEL A, 1994, APPL PHYS LETT, V65, P3019, DOI 10.1063/1.112495; Campbell I. 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Rev. B JUL 1 1999 60 1 477 484 10.1103/PhysRevB.60.477 http://dx.doi.org/10.1103/PhysRevB.60.477 8 Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter Science Citation Index Expanded (SCI-EXPANDED) Materials Science; Physics 218KE 2024-02-29 WOS:000081551100067 J Duck, SC; Rapaport, R Duck, SC; Rapaport, R Long-term treatment with GHRH [1-44] amide in prepubertal children with classical growth hormone deficiency JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM English Article GHRH [1-44]; growth hormone deficiency; treatment THERAPY A cohort of 20 GH deficient prepubertal patients were treated with GHRH [1-44] 10 mu g/kg or 20 mu g/kg twice daily for up to four years (5 patients). GHRH treatment resulted in sustained improvement in height velocity. The mean prepubertal height velocity was 3.57 +/- 1.05 cm/yr pretreatment; 8.49 +/- 1.45 cm/yr at year 1; 6.86 +/- 1.45 cm/yr at year 2; 6.22 +/- 0.74 cm/yr at year 3; and 6.16 +/- 0.97 cm/yr at year 4, IGF-I levels increased and remained within normal range. The difference between the children's and the parents' Ht SD scores significantly diminished from a pretreatment difference of -2.43 to -0.48 after four years of treatment. No adverse effects were noted during treatment. We conclude that twice-daily GHRH [1-44] treatment in a small group of prepubertal GH deficient children resulted in sustained improvement in height and growth velocity, and achieved height SDS approaching closely those of their parents. Northwestern Univ, Evanston Hosp, Dept Pediat, Div Pediat Endocrinol, Evanston, IL 60201 USA; Northwestern Univ, Sch Med, Evanston, IL USA; Children Hosp New Jersey, Newark, NJ USA; Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA Northwestern University; NorthShore University Health System; Northwestern University; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences Duck, SC (corresponding author), Northwestern Univ, Sch Med, Skokie, IL 60077 USA. 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JUL-AUG 1999 12 4 531 536 6 Endocrinology & Metabolism; Pediatrics Science Citation Index Expanded (SCI-EXPANDED) Endocrinology & Metabolism; Pediatrics 214TP 10417969 2024-02-29 WOS:000081343900007 J Dujella, A Dujella, A A proof of the Hoggatt-Bergum conjecture PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY English Article Fibonacci numbers; property of Diophantus; simultaneous Pellian equations; linear form in logarithms; Baker-Davenport reduction procedure It is proved that if k and d are positive integers such that the product of any two distinct elements of the set {F-2k, F2k+2, F2k+4, d} increased by 1 is a perfect square, then d has to be 4F(2k+1)F(2k+2)F(2k+3). This is a generalization of the theorem of Baker and Davenport for k = 1. Univ Zagreb, Dept Math, Zagreb 10000, Croatia University of Zagreb Dujella, A (corresponding author), Univ Zagreb, Dept Math, Bijenicka Cesta 30, Zagreb 10000, Croatia. Dujella, Andrej/B-8060-2009; Dujella, Andrej/AAG-5396-2020 Dujella, Andrej/0000-0001-6867-5811; ARKIN J, 1979, FIBONACCI QUART, V17, P333; BAKER A, 1969, Q J MATH, V20, P129, DOI 10.1093/qmath/20.1.129; BAKER A, 1993, J REINE ANGEW MATH, V442, P19; Dickson L. E., 1966, HIST THEORY NUMBERS, V2, P513; Diophantus of Alexandria, 1974, ARITHMETICS BOOK POL, P103; Dujella A, 1997, PUBL MATH-DEBRECEN, V51, P311; Dujella A, 1998, Q J MATH, V49, P291, DOI 10.1093/qmathj/49.3.291; GRINSTEAD CM, 1978, MATH COMPUT, V32, P936, DOI 10.1090/S0025-5718-1978-0491480-0; HOGGATT VE, 1977, FIBONACCI QUART, V15, P323; JONES BW, 1978, FIBONACCI QUART, V16, P155; KANAGASABAPATHY P, 1975, Q J MATH, V26, P275, DOI 10.1093/qmath/26.1.275; Kedlaya KS, 1998, MATH COMPUT, V67, P833, DOI 10.1090/S0025-5718-98-00918-1; Nagell T., 1951, Introduction to Number Theory; SANSONE G, 1976, ANN MAT PUR APPL, V111, P125 14 36 36 0 1 AMER MATHEMATICAL SOC PROVIDENCE 201 CHARLES ST, PROVIDENCE, RI 02940-2213 USA 0002-9939 P AM MATH SOC Proc. Amer. Math. Soc. JUL 1999 127 7 1999 2005 10.1090/S0002-9939-99-04875-3 http://dx.doi.org/10.1090/S0002-9939-99-04875-3 7 Mathematics, Applied; Mathematics Science Citation Index Expanded (SCI-EXPANDED) Mathematics 186RT hybrid 2024-02-29 WOS:000079743300017 J Dumansky, YD; Nikitina, NG Dumansky, YD; Nikitina, NG The morbidity of the population living under 50 Hz magnetic field exposure EPIDEMIOLOGY English Meeting Abstract Ukrainian Sci Ctr Hyg, UA-253660 Kyiv 94, Ukraine 0 0 0 0 0 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1044-3983 EPIDEMIOLOGY Epidemiology JUL 1999 10 4 338P S118 S118 1 Public, Environmental & Occupational Health Science Citation Index Expanded (SCI-EXPANDED) Public, Environmental & Occupational Health 208JK 2024-02-29 WOS:000080987100367 J Dumay, E; Laligant, A; Zasypkin, D; Cheftel, JC Dumay, E; Laligant, A; Zasypkin, D; Cheftel, JC Pressure- and heat-induced gelation of mixed β-lactoglobulin/polysaccharide solutions:: scanning electron microscopy of gels FOOD HYDROCOLLOIDS English Article high pressure; mixed gels; beta-lactoglobulin; pectins; alginate; phase separation ENZYME-TREATED CASEINS; WHEY PROTEINS; RHEOLOGY; POLYSACCHARIDES; LACTOGLOBULIN; EMULSIONS This study concerns the microstructure of pressure-induced gels (P-gels, 450 MPa, 25 degrees C, 30 min) of mixed beta-lactoglobulin/anionic polysaccharide solutions (12% w/w protein, pH 7.0, plus 0.1-1% w/w sodium alginate, low methoxy pectin or high methoxy pectin). Mixed biopolymer solutions were compatible at ambient temperature and atmospheric pressure in the concentration range studied. Scanning electron microscopy of mixed P-gels from 12% protein-0.1% polysaccharide (PS) solutions revealed microalveoles with a honeycomb structure, suggesting that pressure promoted the formation of water in water emulsion with two distinct phases of different protein and PS concentrations. Increasing PS concentration from 0.1 to 1% (w/w) progressively converted the micro-alveolated structure of P-gels into a coarser porous structure with large pores and pillars", and protein microparticles located in the pores. The trend to phase separation and protein microparticulation increased with PS concentration and varied in the following decreasing order: ALG much greater than LMP much greater than HMP. Phase separation phenomena and the resulting P-gel microstructure probably depend on the net negative charges carried by the PS and on the imparted solution viscosity. Heating the mixed protein-polysaccharide solutions at 87 degrees C for 40 min also induced phase separation, porous structures and protein microparticulation. The results suggest that phase separation in the presence of an anionic polysaccharide is triggered by beta-lactoglobulin unfolding and/or aggregation. (C) 1999 Elsevier Science Ltd. All rights reserved.
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