Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens

被引：91

作者：

Cortes-Vieyra, Ricarda ^{[1
]}

Bravo-Patino, Alejandro ^{[1
]}

Valdez-Alarcon, Juan J. ^{[1
]}

Cajero Juarez, Marcos ^{[1
]}

Brett Finlay, B. ^{[2
]}

Baizabal-Aguirre, Victor M. ^{[1
]}

机构：

[1] Univ Michoacana, Ctr Multidisciplinario Estudios Biotecnol, Fac Med Vet & Zootecnia, Morelia 58893, Michoacan, Mexico

[2] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

来源：

JOURNAL OF INFLAMMATION-LONDON | 2012年 / 9卷

关键词：

GSK3; beta; NF-kappa B; Inflammation; Virulence factors; Bacterial infection; NF-KAPPA-B; SIGNALING PATHWAY; CELLS; LIPOPOLYSACCHARIDE; ACTIVATION; CATENIN; IL-10; AKT; PHOSPHORYLATION; EXPRESSION;

D O I：

10.1186/1476-9255-9-23

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Glycogen synthase kinase 3 beta (GSK3 beta) plays a fundamental role during the inflammatory response induced by bacteria. Depending on the pathogen and its virulence factors, the type of cell and probably the context in which the interaction between host cells and bacteria takes place, GSK3 beta may promote or inhibit inflammation. The goal of this review is to discuss recent findings on the role of the inhibition or activation of GSK3 beta and its modulation of the inflammatory signaling in monocytes/macrophages and epithelial cells at the transcriptional level, mainly through the regulation of nuclear factor-kappaB (NF-kappa B) activity. Also included is a brief overview on the importance of GSK3 in non-inflammatory processes during bacterial infection.

引用

页数：9

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