Crohn's disease

被引：449

作者：

Shanahan, F

机构：

[1] Cork Univ Hosp, Dept Med, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Cork, Ireland

来源：

LANCET | 2002年 / 359卷 / 9300期

关键词：

D O I：

10.1016/S0140-6736(02)07284-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Crohn's disease is a disorder mediated by T lymphocytes which arises In genetically susceptible Individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria, Regulation of Immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity Is probable, with various underlying defects associated with a similar pathophysiological outcome. Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora Is becoming a realistic option.

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收藏

页码：62 / 69

页数：8

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