Monoclonal antibody therapeutics: history and future

被引：415

作者：

Buss, Nicholas A. P. S. ^{[1
]}

Henderson, Simon J. ^{[1
]}

McFarlane, Mary ^{[1
]}

Shenton, Jacintha M. ^{[1
]}

de Haan, Lolke ^{[1
]}

机构：

[1] MedImmune, Biol Safety Assessment, Cambridge CB21 6GH, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 05期

关键词：

BLOOD-BRAIN-BARRIER; HUMAN-IGG ANTIBODIES; IN-VIVO; BISPECIFIC ANTIBODIES; LINKER STABILITY; CANCER-THERAPY; HALF-LIFE; T-CELLS; MOUSE; ISOTYPE;

D O I：

10.1016/j.coph.2012.08.001

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Over the last three decades, monoclonal antibodies have made a dramatic transformation from scientific tools to powerful human therapeutics. At present, approximately 30 therapeutic monoclonal antibodies are marketed in the United States and Europe in a variety of indications, with sales in the US alone reaching approximately $18.5 billion in 2010. This review describes how antibody engineering has revolutionized drug discovery and what are considered the key areas for future development in the monoclonal antibody therapy field.

引用

页码：615 / 622

页数：8

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