Theoretical and Experimental Evidence for Hysteresis in Cell Proliferation

被引：11

作者：

Bai, Shaochun ^{[1
]}

Goodrich, David ^{[1
]}

Thron, C. Dennis

Tecarro, Edwin ^{[2
]}

Obeyesekere, Mandri ^{[3
]}

机构：

[1] Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

[2] Univ St Thomas, Dept Math, Houston, TX 77006 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Biomath, 1515 Holcomb Blvd, Houston, TX 77030 USA

来源：

CELL CYCLE | 2003年 / 2卷 / 01期

关键词：

Cell cycle; G(1) phase; Mathematical model; Cyclins; Retinoblastoma; E2; Hysteresis;

D O I：

10.4161/cc.2.1.186

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We propose a mathematical model for the regulation of the G1-phase of the mammalian cell cycle taking into account interactions of cyclin D/cdk4, cyclin E/cdk2, Rb and E2F. Mathematical analysis of this model predicts that a change in the proliferative status in response to a change in concentrations of serum growth factors will exhibit the property of hysteresis: the concentration of growth factors required to induce proliferation is higher than the concentration required to maintain proliferation. We experimentally confirmed this prediction in mouse embryonic fibroblasts in vitro. In agreement with the mathematical model, this indicates that changes in proliferative mode caused by small changes in concentrations of growth factors are not easily reversible. Based on this study, we discuss the importance of proliferation hysteresis for cell cycle regulation.

引用

页码：46 / 52

页数：7

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