A Prospective, Multicenter Survey on Causes of Chronic Cough in China

被引：562

作者：

Lai, Kefang ^{[1
]}

Chen, Ruchong ^{[1
]}

Lin, Jiangtao ^{[2
]}

Huang, Kewu ^{[3
]}

Shen, Huahao ^{[4
]}

Kong, Lingfei ^{[5
]}

Zhou, Xin ^{[6
]}

Luo, Zhiyang ^{[7
]}

Yang, Lan ^{[8
]}

Wen, Fuqiang ^{[9
]}

Zhong, Nanshan ^{[1
]}

机构：

[1] Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China

[2] China Japan Friendship Hosp, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Beijing, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Hangzhou 310003, Zhejiang, Peoples R China

[5] China Med Univ, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China

[6] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Shanghai 200030, Peoples R China

[7] First Peoples Hosp Foshan, Foshan, Guangdong, Peoples R China

[8] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Xian 710049, Shanxi, Peoples R China

[9] Sichuan Univ, West China Hosp, West China Sch Med, Chengdu 610064, Sichuan, Peoples R China

来源：

CHEST | 2013年 / 143卷 / 03期

关键词：

GASTROESOPHAGEAL-REFLUX DISEASE; CHRONIC NONPRODUCTIVE COUGH; RESPIRATORY-HEALTH-SURVEY; CHRONIC PERSISTENT COUGH; EOSINOPHILIC BRONCHITIS; DIAGNOSTIC PROTOCOL; ASTHMA; COMMUNITY; GUIDELINES; MANAGEMENT;

D O I：

10.1378/chest.12-0441

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Background: The causes of chronic cough in China and its relations with geography, seasonality, age, and sex are largely uncertain. Methods: A prospective, multicenter survey was conducted to evaluate patients with chronic cough across five regions in China by using a modified diagnostic algorithm. The effects of geography, seasonality, age, and sex on spectrum of chronic cough were also investigated. Results: The current study evaluated 704 adult patients, including 315 men (44.7%) and 389 women (55.3%). The causes of chronic cough were determined in 640 subjects (90.9%). Common causes included cough variant asthma (CVA) (32.6%), upper airway cough syndrome (UACS) (18.6%), eosinophilic bronchitis (EB) (17.2%), and atopic cough (AC) (13.2%). Collectively, these four causes accounted for 75.2% to 87.6% across five different regions without significant difference (P>.05), although there was variation on single causes. Gastroesophageal reflux-related cough was identified in 4.6% of causes. Seasonality, sex, and age were not associated with the spectrum of chronic cough (all P>.05). Conclusion: CVA, UACS, EB, and AC were common causes of chronic cough in China. Geography, seasonality, age, and sex were not associated with the spectrum of chronic cough. CHEST 2013; 143(3):613-620

引用

页码：613 / 620

页数：8

共 35 条

[1]

[Anonymous], 2011, INT J RESP

[2]

Chronic tonsillar enlargement and cough: preliminary evidence of a novel and treatable cause of chronic cough [J].

Birring, SS ;

Passant, C ;

Patel, RB ;

Prudon, B ;

Murty, GE ;

Pavord, ID .

EUROPEAN RESPIRATORY JOURNAL, 2004, 23 (02) :199-201

[3]

Eosinophilic bronchitis is an important cause of chronic cough [J].

Brightling, CE ;

Ward, R ;

Goh, KL ;

Wardlaw, AJ ;

Pavord, ID .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (02) :406-410

[4]

THE EUROPEAN-COMMUNITY-RESPIRATORY-HEALTH-SURVEY [J].

BURNEY, PGJ ;

LUCZYNSKA, C ;

CHINN, S ;

JARVIS, D ;

VERMEIRE, P ;

DAHL, R ;

NIELSEN, N ;

MAGNUSSEN, H ;

WICHMANN, H ;

PAPAGEORGIOU, N ;

ANTO, J ;

CAPELASTEGUI, A ;

CASTILLO, J ;

MALDONADO, J ;

MORATALLA, J ;

QUIROS, R ;

BOUSQUET, J ;

NEUKIRCH, F ;

PIN, I ;

TAYTARD, A ;

TECULESCU, D ;

PRICHARD, J ;

BUGIANI, M ;

DEMARCO, R ;

CASCIO, VL ;

RIJCKEN, B ;

AVILA, R ;

LOUREIRO, C ;

MARQUES, A ;

BURR, M ;

HALL, R ;

HARRISON, B ;

STARK, J ;

FLOREY, C ;

POPP, W ;

GISLASON, T ;

GULSVIK, A ;

ACKERMANNLIEBRICH, U ;

LINDHOLM, N ;

BOMAN, G ;

ROSENHALL, L ;

AITKHALED, N ;

ABRAMSON, M ;

MANFREDA, J ;

CHOWGULE, R ;

CRANE, J ;

STEPANOV, I ;

BUIST, S .

EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (05) :954-960

[5]

Prospective study of dietary patterns and persistent cough with phlegm among Chinese Singaporeans [J].

Butler, LM ;

Koh, WP ;

Lee, HP ;

Tseng, M ;

Yu, MC ;

London, SJ .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (03) :264-270

[6]

Chronic cough 1 - Prevalence, pathogenesis, and causes of chronic cough [J].

Chung, Kian Fan ;

Pavord, Ian D. .

LANCET, 2008, 371 (9621) :1364-1374

[7]

Crapo RO, 2000, AM J RESP CRIT CARE, V161, P309

[8]

Gastroesophageal reflux among different racial groups in the United States [J].

El-Serag, HB ;

Petersen, NJ ;

Carter, J ;

Graham, DY ;

Richardson, P ;

Genta, RM ;

Rabeneck, L .

GASTROENTEROLOGY, 2004, 126 (07) :1692-1699

[9]

Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms [J].

Ford, A. C. ;

Forman, D. ;

Moayyedi, P. ;

Morice, A. H. .

THORAX, 2006, 61 (11) :975-979

[10]

Importance of atopic cough, cough variant asthma and sinobronchial syndrome as causes of chronic cough in the Hokuriku area of Japan [J].

Fujimura, M ;

Abo, M ;

Ogawa, H ;

Nishi, K ;

Kibe, Y ;

Hirose, T ;

Nakatsumi, Y ;

Iwasa, K .

RESPIROLOGY, 2005, 10 (02) :201-207

← 1 2 3 4 →