Asymmetric Darzens reaction utilizing chloromethyl phenyl sulfone under phase-transfer catalyzed conditions

被引：56

作者：

Arai, S ^{[1
]}

Shioiri, T ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

TETRAHEDRON | 2002年 / 58卷 / 07期

关键词：

asymmetric reaction; Darzens reaction; diastereoselection; epoxides; phase-transfer;

D O I：

10.1016/S0040-4020(01)01244-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of the catalytic asymmetric Darzens reaction utilizing chloromethyl phenyl sulfone is described. The reaction smoothly proceeded to give alpha,beta-epoxysulfones with satisfactory enantio selectivity (up to 83% ee) using chiral quaternary ammonium salts as the phase transfer catalyst. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1407 / 1413

页数：7

共 21 条

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