Piecing Together the Puzzle of Severe Malaria

被引：41

作者：

Cunnington, Aubrey J. ^{[1
]}

Walther, Michael ^{[2
]}

Riley, Eleanor M. ^{[3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Paediat Sect, London W2 1PG, England

[2] NIAID, NIH, Div Intramural Res, Immune Regulat Sect,Lab Malaria Immunol & Vaccino, Rockville, MD 20852 USA

[3] London Sch Hyg & Trop Med, Dept Immunol & Infect, London WC1E 7HT, England

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2013年 / 5卷 / 211期

基金：

英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; PARASITE SEQUESTRATION; CEREBRAL MALARIA; GENES; COMMUNICATION; MECHANISMS; CHILDREN; BINDING; SUBSET;

D O I：

10.1126/scitranslmed.3007432

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identifed as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these fndings into new therapies.

引用

页数：5

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