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Fragmentation of angiotensin-I converting enzyme inhibitory peptides from bonito meat under intestinal digestion conditions and their characterization

被引：11
作者：
Hasan, F.
Kumada, Y.
Hashimoto, N.
Katsuda, T.
Terashima, M.
Katoh, S.
机构：
[1] Kobe Univ, Grad Sch Sci & Technol, Dept Mol Sci & Mat Engn, Kobe, Hyogo 6578501, Japan
[2] Kobe Univ, Fac Engn, Kobe, Hyogo, Japan
[3] Kobe Womens Coll Pharm, Dept Biosphere Sci, Nishinomiya, Hyogo, Japan
[4] Okayama Univ, Dept Biosci & Biotechnol, Okayama, Japan
来源：
FOOD AND BIOPRODUCTS PROCESSING | 2006年 / 84卷 / C2期
关键词：
angiotensin-I converting enzyme; inhibitory peptide; anti-peptide antibody; intestinal digestion; bonito; competitive inhibitor;
D O I：
10.1205/fbp.05152
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];
摘要：
Kinetics of fragmentation of angiotensin-I converting enzyme inhibitory peptides obtained by digestion in gastric juice were studied under intestinal digestion conditions and their inhibitory activities were determined. A fragment IKYGD produced by digestion, as well as IKWGD synthesized, showed similar inhibitory activity to the original peptides. These peptides somehow were resistant to tryptic and/or chymotryptic digestion, and IK + aromatic amino acid might be important functional parts in some kinds of ACE inhibitory peptides.
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收藏
页码：135 / 138
页数：4
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