Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

被引：43

作者：

Firbank, M

Okada, E

Delpy, DT

机构：

[1] Department of Medical Physics, University College London, London WC1E 6JA

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 1997年 / 42卷 / 03期

关键词：

D O I：

10.1088/0031-9155/42/3/002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the brood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (> 0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

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收藏

页码：465 / 477

页数：13

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