The influence of lipid composition and lamellarity of liposomes on the physical stability of liposomes upon storage

被引：106

作者：

duPlessis, J ^{[1
]}

Ramachandran, C ^{[1
]}

Weiner, N ^{[1
]}

Muller, DG ^{[1
]}

机构：

[1] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI 48109 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 127卷 / 02期

关键词：

physical stability; liposomes; lamellarity; lipid composition; storage;

D O I：

10.1016/0378-5173(95)04281-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The physical stability of the four liposomal systems was determined on storage at 4 and 25 degrees C over a 6-month period. A correlation of the mean volume diameter, zeta potential and pH lead to the conclusion that stability follows the order of egg lecithin (PC)/cholesterol (CH)/stearylamine (SA) < PC/CH/phosphatidylserine (PS) < bovine brain ceramides (CM)/CH/palmitic acid (PA)/CS < PC/CH/cholesteryl sulphate (CS) at 4 degrees C, as well as at 25 degrees C, after a 6-month storage period. Large unilamellar vesicles (REV) proved to be superior to multilamellar liposomes (MLV) and dehydration/rehydration liposomes (DRV) systems as far as physical stability was concerned. Instability was exaggerated in the systems stored at 25 degrees C as compared to storage at 4 degrees C.

引用

页码：273 / 278

页数：6

共 11 条

[1] DIFFUSION OF UNIVALENT IONS ACROSS LAMELLAE OF SWOLLEN PHOSPHOLIPIDS [J].