WNT signalling pathways as therapeutic targets in cancer

被引：1768

作者：

Anastas, Jamie N. ^{[1
,2
,3
,4
,5
]}

Moon, Randall T. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98109 USA

[2] Univ Washington, Dept Pharmacol, Seattle, WA 98109 USA

[3] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98109 USA

[4] Univ Washington, Mol & Cellular Biol Grad Program, Seattle, WA 98109 USA

[5] Univ Washington, Sch Med, Seattle, WA 98109 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 01期

关键词：

WNT/BETA-CATENIN PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; FAMILIAL ADENOMATOUS POLYPOSIS; NUCLEAR BETA-CATENIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOCALIZED PROSTATE-CANCER; HUMAN COLORECTAL-CANCER; RENAL-CELL CARCINOMA; LEUKEMIC STEM-CELLS; BREAST-CANCER;

D O I：

10.1038/nrc3419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our appreciation for the complex roles for WNT signalling pathways in cancer has increased dramatically. WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis. Although WNT signalling pathways have been difficult to target, improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models, thus setting the stage for clinical trials in humans.

引用

页码：11 / 26

页数：16

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