Losartan improves diastolic ventricular filling of hypertensive patients with diastolic dysfunction

被引:7
作者
Ayoub, JCA
Vitola, JV
Parro, A
Costa, OMC
Delgado, AS
de Parma, AHC
Takakura, IT
机构
[1] Inst Mol Cardiovasc, BR-15015210 Sao Paulo, Brazil
[2] Med Sch Sao Jose Rio Preto, Sao Jose Do Rio Preto, Brazil
来源
HYPERTENSION RESEARCH-CLINICAL AND EXPERIMENTAL | 1999年 / 22卷 / 02期
关键词
angiotensin II antagonists; diastolic dysfunction; losartan;
D O I
10.1291/hypres.22.155
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
To evaluate the role of losartan on left ventricular (LV) function of hypertensive patients. Hypertensive patients (n = 19) underwent evaluation of systolic and diastolic LV function, using radionuclide ventriculography (RVG), before and at 3 mo into the treatment with the angiotensin ZI antagonist losartan. All patients underwent a baseline 12 lead ECG and an echocardiogram (ECHO), which was also repeated at 3 mo into treatment. Results are expressed as mean +/- SEM and statistics were performed using paired t-test. A p value less than or equal to 0.05 was considered significant. Treatment with losartan for 3 mo had no effect on LV mass measured by echo (141 +/- 5 vs. 139 +/- 6 g/m(2)). The LV ejection fraction, measured by RVG, was unchanged by treatment when compared to the baseline study (58 +/- 2% vs. 57 +/- 2%, respectively, p = 0.49). Considering all patients involved in the study (n = 19), the LV "Peak Filling Rate" (PFR), a parameter of diastolic function measured by RVG, was also unchanged by treatment when compared to baseline (2.5 +/- 0.2 EDV/s vs. 2.5 +/- 0.3 EDV/s, respectively, p = 0.9). However the analysis of those patients with evidence of diastolic dysfunction (n = 12) on the baseline RVG (PFR < 2.5 EVD/s), demonstrated significant improvement of LV filling after therapy with losartan (PFR = 1.8 +/- 0.1 EDV/s vs. 2.3 +/- 0.2 EDV/s, respectively, p = 0.05). This change was associated with improvement of symptoms. Our results demonstrated that hypertensive patients with diastolic dysfunction on radionuclide ventriculography have significant improvement of ventricular filling at 3 mo into treatment with losartan.
引用
收藏
页码:155 / 159
页数:5
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