Sol-gel synthesis of SiO2-CaO-P2O5 glasses: Influence of the heat treatment on their bioactivity and biocompatibility

被引：59

作者：

Catauro, M. ^{[1
]}

Bollino, F. ^{[1
]}

Renella, R. A. ^{[1
]}

Papale, F. ^{[1
]}

机构：

[1] Univ Naples 2, Dept Ind & Informat Engn, Naples, Italy

来源：

CERAMICS INTERNATIONAL | 2015年 / 41卷 / 10期

关键词：

SiO2-CaO-P2O5; glasses; Sol-gel synthesis; Heat treatment; Bioactivity test; Cytotoxicity evaluation; IN-VITRO BIOACTIVITY; APATITE FORMATION; BIOLOGICAL EVALUATION; MECHANICAL-PROPERTIES; THERMAL-STABILITY; SILICATE GLASS; HYDROXYAPATITE; SPECTROSCOPY; CERAMICS;

D O I：

10.1016/j.ceramint.2015.06.075

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

081705 [工业催化]; 082905 [生物质能源与材料];

摘要：

The main goal of the present work is to synthesize SiO2 center dot CaO center dot P2O5 bioactive glasses by a sol-gel method. The influence of the Ca/P molar ratio and of heat treatment on the biological properties of the glassy materials has been investigated. Two gels with different Ca/P molar ratios have been prepared. The gels obtained have been subjected to heat-treatment at three different temperatures: 120 degrees C, 600 degrees C and 1000 degrees C. The bioactivity of the glasses has been evaluated by soaking the samples in a simulated body fluid. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) allowed the presence of an hydroxyapatite layer on the surface of the samples after 7, 14 and 21 days of exposure to be detected. Moreover, the biocompatibility of the obtained glasses has been assessed by means of WST-8 assay using NIH 3T3 murine fibroblast cells. It has been shown that both the Ca/P molar ratio and heat-treatment have a significant influence on the biological properties of the materials. The sample with the higher calcium content and heat-treated at 600 degrees C has been found to be the most bioactive. The biocompatibility of the materials treated at 600 degrees C and 1000 degrees C is much higher than that of those heated at 120 degrees C. (C) 2015 Published by Elsevier Ltd and Techna Group S.r.l.

引用

页码：12578 / 12588

页数：11

共 45 条

[1]

Chemical synthesis of bone-like carbonate hydroxyapatite from hen eggshells and its characterization [J].

Acevedo-Davila, J. L. ;

López-Cuevas, J. ;

Vargas-Gutierrez, G. ;

Rendón-Angeles, J. C. ;

Méndez-Nonell, J. .

BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO, 2007, 46 (05) :225-231

[2]

Bioactive nanocrystalline wollastonite synthesized by sol-gel combustion method by using eggshell waste as calcium source [J].

Anjaneyulu, U. ;

Sasikumar, S. .

BULLETIN OF MATERIALS SCIENCE, 2014, 37 (02) :207-212

[3]

[Anonymous], AAPP ATTI ACCAD PELO

[4]

Development and in vitro characterization of sol-gel derived CaO-P2O5-SiO2-ZnO bioglass [J].

Balamurugan, Anbalagan ;

Balossier, Gerard ;

Kannan, Sanjeevi ;

Michel, Jean ;

Rebelo, Avito H. S. ;

Ferreira, Jose M. F. .

ACTA BIOMATERIALIA, 2007, 3 (02) :255-262

[5]

Barralet J, 1998, J BIOMED MATER RES, V41, P79, DOI 10.1002/(SICI)1097-4636(199807)41:1<79::AID-JBM10>3.0.CO

[6]

2-C

[7]

Bizari D, 2013, CERAM-SILIKATY, V57, P201

[8]

Brinker C.J., 1989, Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing

[9]

Bun A., 1997, J THERM ANAL, V49, P863

[10]

Influence of the polymer amount on bioactivity and biocompatibility of SiO2/PEG hybrid materials synthesized by sol-gel technique [J].

Catauro, M. ;

Bollino, F. ;

Papale, F. ;

Gallicchio, M. ;

Pacifico, S. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 48 :548-555

← 1 2 3 4 5 →