Evidence for the presence of clofazimine and its distribution in the healthy mouse brain

被引：25

作者：

Baijnath, Sooraj ^{[1
]}

Naiker, Suhashni ^{[1
]}

Shobo, Adeola ^{[1
]}

Moodley, Chivonne ^{[2
]}

Adamson, John ^{[2
]}

Ngcobo, Bongani ^{[2
]}

Bester, Linda A. ^{[3
]}

Singh, Sanil ^{[3
]}

Kruger, Hendrik G. ^{[1
]}

Naicker, Tricia ^{[1
]}

Govender, Thavendran ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Pharm & Pharmacol, Catalysis & Peptide Res Unit, Durban, South Africa

[2] Univ KwaZulu Natal, Nelson R Mandela Sch Med, KwaZulu Natal Res Inst TB & HIV, Durban, South Africa

[3] Univ KwaZulu Natal, Biomed Resource Unit, Durban, South Africa

来源：

JOURNAL OF MOLECULAR HISTOLOGY | 2015年 / 46卷 / 4-5期

基金：

新加坡国家研究基金会;

关键词：

Clofazimine; Brain distribution; MALDIMSI; SERIES;

D O I：

10.1007/s10735-015-9634-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

This is the first report of clofazimine (CFZ) penetration and distribution in normal mouse brain. Mice were administered 25 mg/kg CFZ or 100 mg/kg CFZ orally, daily for 2 weeks. Animals were sacrificed and blood and brain tissues were harvested. Liquid chromatography tandem mass spectrometry showed high concentrations of CFZ in homogenized brain, with 100 mg/kg dose having significantly higher concentration than 25 mg/kg. Matrix-assisted laser desorption/ionization spectrometric imaging of brain sections showed widespread tissue distribution of CFZ. Our results show dose dependent localization in brain.

引用

页码：439 / 442

页数：4

共 20 条

[1]

[Anonymous], 2013, WHO GLOB TUB REP 201

[2]

Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response [J].