Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women

被引：90

作者：

Rejnmark, L

Buus, NH

Vestergaard, P

Heickendorff, L

Andreasen, F

Larsen, ML

Mosekilde, L

机构：

[1] Aarhus Univ Hosp, Dept Endocrinol & Metab C, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Fac Hlth Sci, Aarhus, Denmark

[3] Aarhus Univ, Fac Hlth Sci, Ctr Clin Pharmacol, Aarhus, Denmark

[4] Aarhus Univ Hosp, Dept Clin Biochem, DK-8000 Aarhus, Denmark

[5] Aarhus Univ Hosp, Dept Med & Cardiol, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 05期

关键词：

clinical trials; osteoporosis; treatments; bone densitometry; bone turnover markers;

D O I：

10.1359/JBMR.040209

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

To study effects of statins on human bone, 82 postmenopausal women were randomized to I-year treatment with simvastatin 40 mg/day or placebo. The study showed no effect of simvastatin on biochemical bone markers or on BMD at the hip or spine. Thus, our results do not support a general beneficial effect of simvastatin on bone.

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收藏

页码：737 / 744

页数：8

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