Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice

被引：6

作者：

Vergnes, L

Baroukh, N

Léhy, T

Moizo, L

Bado, A

Baralle, M

Baralle, FE

Zakin, MM

Ochoa, A

机构：

[1] Inst Pasteur, Unite Express Genes Eucaryotes, F-75724 Paris 15, France

[2] Hop Bichat Claude Bernard, INSERM 10, Unite Rech Gastroenterol, F-75877 Paris 18, France

[3] Int Ctr Genet Engn & Biotechnol, I-34012 Trieste, Italy

[4] INRA, Unite Differenciat Cellulaire, F-78352 Jouy En Josas, France

来源：

FEBS LETTERS | 1999年 / 460卷 / 01期

关键词：

transgenic mouse; gastric mucosa; apolipoprotein A-IV; indomethacin; ulcer; gastric acid secretion;

D O I：

10.1016/S0014-5793(99)01332-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the involvement of human apolipoprotein A-IV (apoA-IV) in gastric acid secretion and ulcer formation in recently generated apoA-IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43-77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa, In addition, no variation in gastrin levels was observed. Transgenics mere protected against indomethacin-induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA-IV expression can regulate gastric acid secretion and ulcer development. (C) 1999 Federation of European Biochemical Societies.

引用

收藏

页码：178 / 181

页数：4

相关论文

共 17 条

[1] INTESTINAL EXPRESSION OF HUMAN APOLIPOPROTEIN A-IV IN TRANSGENIC MICE FAILS TO INFLUENCE DIETARY-LIPID ABSORPTION OR FEEDING-BEHAVIOR [J].

AALTOSETALA, K ;

BISGAIER, CL ;

HO, A ;

KIEFT, KA ;

TRABER, MG ;

KAYDEN, HJ ;

RAMAKRISHNAN, R ;

WALSH, A ;

ESSENBURG, AD ;

BRESLOW, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (04) :1776-1786

[2] APOLIPOPROTEIN A-IV SYNTHESIS IN RAT INTESTINE - REGULATION BY DIETARY TRIGLYCERIDE [J].

APFELBAUM, TF ;

DAVIDSON, NO ;

GLICKMAN, RM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (05) :G662-G666

[3] Regulation of the human apolipoprotein AIV gene expression in transgenic mice [J].

Baralle, M ;

Vergnes, L ;

Muro, AF ;

Zakin, MM ;

Baralle, FE ;

Ochoa, A .

FEBS LETTERS, 1999, 445 (01) :45-52

[4] POSSIBLE ROLE OF TRANSFORMING GROWTH-FACTOR ALPHA IN THE PATHOGENESIS OF MENETRIERS DISEASE - SUPPORTIVE EVIDENCE FROM HUMANS AND TRANSGENIC MICE [J].

DEMPSEY, PJ ;

GOLDENRING, JR ;

SOROKA, CJ ;

MODLIN, IM ;

MCCLURE, RW ;

LIND, CD ;

AHLQUIST, DA ;

PITTELKOW, MR ;

LEE, DC ;

SANDGREN, EP ;

PAGE, DL ;

COFFEY, RJ .

GASTROENTEROLOGY, 1992, 103 (06) :1950-1963

[5] Impaired gastric acid secretion in gastrin-deficient mice [J].

Friis-Hansen, L ;

Sundler, F ;

Li, Y ;

Gillespie, PJ ;

Saunders, TL ;

Greenson, JK ;

Owyang, C ;

Rehfeld, JF ;

Samuelson, LC .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (03) :G561-G568

[6] INCREASED APOLIPOPROTEIN-A-IV IN RAT MESENTERIC LYMPH AFTER LIPID MEAL ACTS AS A PHYSIOLOGICAL SIGNAL FOR SATIATION [J].

FUJIMOTO, K ;

CARDELLI, JA ;

TSO, P .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (06) :G1002-G1006

[7] SUPPRESSION OF FOOD-INTAKE BY APOLIPOPROTEIN A-IV IS MEDIATED THROUGH THE CENTRAL-NERVOUS-SYSTEM IN RATS [J].

FUJIMOTO, K ;

FUKAGAWA, K ;

SAKATA, T ;

TSO, P .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1830-1833

[8] Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice [J].

Koh, TJ ;

Goldenring, JR ;

Ito, S ;

Mashimo, H ;

Kopin, AS ;

Varro, A ;

Dockray, GJ ;

Wang, TC .

GASTROENTEROLOGY, 1997, 113 (03) :1015-1025

[9] Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice [J].

Langhans, N ;

Rindi, G ;

Chiu, M ;

Rehfeld, JF ;

Ardman, B ;

Beinborn, M ;

Kopin, AS .

GASTROENTEROLOGY, 1997, 112 (01) :280-286

[10]

LEHY T, 1973, GASTROENTEROLOGY, V64, P421