Antifungals: what's in the pipeline

被引：36

作者：

Tkacz, JS

DiDomenico, B

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

[2] Schering Plough Corp, Res Inst K15 4700, Kenilworth, NJ 07033 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(00)00248-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The therapeutic landscape for mycotic infections is shifting. New generation azoles that are active against clinically relevant, drug-resistant fungal pathogens have improved bioavailability, half-lives and safety profiles. Acylated cyclic peptide inhibitors of beta (1,3)glucan synthesis with origins as fungal metabolites provide an alternative and highly-selective mode of action, targeting cell-wall biogenesis in important pathogens such as Candida and Aspergillus species. The development, in each structural class, of compounds that have advanced to late-stage clinical trials is summarized in this review.

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页码：540 / 545

页数：6

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