The national heart, lung, and blood institute pediatric circulatory support program

被引:129
作者
Baldwin, JT
Borovetz, HS
Duncan, BW
Gartner, MJ
Jarvik, RK
Weiss, WJ
Hoke, TR
机构
[1] NHLBI, Div Heart & Vasc Dis, Bethesda, MD 20892 USA
[2] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA
[4] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA
[5] Cleveland Clin Fdn, Dept Pediat & Congenital Heart Surg, Cleveland, OH 44195 USA
[6] Cleveland Clin Fdn, Dept Biomed Engn, Cleveland, OH 44195 USA
[7] Ension Inc, Pittsburgh, PA USA
[8] Jarvik Heart Inc, New York, NY USA
[9] Penn State Univ, Coll Med, Dept Surg, Hershey, PA 17033 USA
[10] Penn State Univ, Coll Med, Dept Bioengn, Hershey, PA 17033 USA
关键词
heart-assist device; pediatrics; congenital heart defects; heart diseases; heart failure;
D O I
10.1161/CIRCULATIONAHA.105.571422
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Options for the circulatory support of pediatric patients under the age of 5 years are currently limited to short-term extracorporeal devices, the use of which is often complicated by infection, bleeding, and thromboembolism. Recognizing this void, the National Heart, Lung, and Blood Institute solicited proposals for the development of novel circulatory support systems for infants and children from 2 to 25 kg with congenital or acquired cardiovascular disease. Five contracts were awarded to develop a family of devices that includes (1) an implantable mixed-flow ventricular assist device designed specifically for patients up to 2 years of age, (2) another mixed-flow ventricular assist device that can be implanted intravascularly or extravascularly depending on patient size, (3) compact integrated pediatric cardiopulmonary assist systems, (4) apically implanted axial-flow ventricular assist devices, and (5) pulsatile-flow ventricular assist devices. The common objective for these devices is to reliably provide circulatory support for infants and children while minimizing risks related to infection, bleeding, and thromboembolism. The devices are expected to be ready for clinical studies at the conclusion of the awards in 2009.
引用
收藏
页码:147 / 155
页数:9
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