In vitro susceptibilities of Chlamydia pneumoniae isolates from German patients and synergistic activity of antibiotic combinations

被引：12

作者：

Freidank, HM ^{[1
]}

Losch, P ^{[1
]}

Vögele, H ^{[1
]}

Wiedmann-Al-Ahmad, M ^{[1
]}

机构：

[1] Univ Freiburg, Inst Med Microbiol & Hyg, Dept Bacteriol, D-79104 Freiburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 07期

关键词：

D O I：

10.1128/AAC.43.7.1808

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibilities of six Chlamydia pneumoniae type strains and of six German patient isolates to erythromycin, azithromycin, roxithromycin, clarithromycin, doxycycline, ofloxacin, and rifampin were investigated. MICs and minimal chlamydicidal concentrations were all within the ranges reported previously. Combinations of azithromycin with either ofloxacin, doxycycline, or rifampin, as well as combinations of three antibiotics (rifampin, azithromycin, and ofloxacin or doxycycline), showed synergistic activity against C. pneumoniae.

引用

页码：1808 / 1810

页数：3

共 27 条

[1] IN-VITRO ACTIVITY OF AZITHROMYCIN (CP-62,993) AGAINST CHLAMYDIA-TRACHOMATIS AND CHLAMYDIA-PNEUMONIAE [J].

AGACFIDAN, A ;

MONCADA, J ;

SCHACHTER, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (09) :1746-1748

[2] SUSCEPTIBILITY OF CHLAMYDIA-PNEUMONIAE TO ORAL-AGENTS COMMONLY USED IN THE TREATMENT OF RESPIRATORY-INFECTION [J].

BEALE, AS ;

MASSON, ND .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (06) :1072-1074

[3] MYCOPLASMA-PNEUMONIAE AND CHLAMYDIA-PNEUMONIAE IN PEDIATRIC COMMUNITY-ACQUIRED PNEUMONIA - COMPARATIVE EFFICACY AND SAFETY OF CLARITHROMYCIN VS ERYTHROMYCIN ETHYLSUCCINATE [J].

BLOCK, S ;

HEDRICK, J ;

HAMMERSCHLAG, MR ;

CASSELL, GH ;

CRAFT, JC .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1995, 14 (06) :471-477

[4]

Eliopolous GM., 1996, Antibiotics in laboratory medicine, P330

[5] Persistent Chlamydia pneumoniae infection in a Swedish family [J].

Falck, G ;

Gnarpe, J ;

Gnarpe, H .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1996, 28 (03) :271-273

[6] A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia [J].

File, TM ;

Segreti, J ;

Dunbar, L ;

Player, R ;

Kohler, R ;

Williams, RR ;

Kojak, C ;

Rubin, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :1965-1972

[7]

Freidank HM, 1996, MED MICROBIOL LETT, V5, P173

[8] In vitro activities of azithromycin and doxycycline against 15 isolates of Chlamydia pneumoniae [J].

Gnarpe, J ;

Eriksson, K ;

Gnarpe, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) :1843-1845

[9]

GUMP DW, 1996, ANTIBIOTICS LAB MED, P212

[10]

Gupta S, 1997, CIRCULATION, V96, P404

← 1 2 3 →