Anthranilic diamides: A new class of insecticides with a novel mode of action, ryanodine receptor activation

被引:498
作者
Cordova, D [1 ]
Benner, EA [1 ]
Sacher, MD [1 ]
Rauh, JJ [1 ]
Sopa, JS [1 ]
Lahm, GP [1 ]
Selby, TP [1 ]
Stevenson, TM [1 ]
Flexner, L [1 ]
Gutteridge, S [1 ]
Rhoades, DF [1 ]
Wu, L [1 ]
Smith, RM [1 ]
Tao, Y [1 ]
机构
[1] DuPont Crop Protect, Stine Haskell Res Ctr, Newark, DE 19714 USA
关键词
anthranilic diamide; anthranilamide; insecticide; insecticidal; ryanodine; RyR; calcium channel; mode of action; Drosophila; PC12;
D O I
10.1016/j.pestbp.2005.07.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Development of insecticides with unique modes of action is necessary to combat widespread insecticide resistance. A new class of insecticides has been discovered, the anthranilic diamides, that provides exceptional control through action on a novel target, the ryanodine receptor. Anthranilic diamides potently activate this receptor, releasing stored calcium from the sarcoendoplasmic reticulum causing impaired regulation Of muscle contraction. Expression of a recombinant Drosophila ryanodine receptor in a lepidopteran cell line confers sensitivity to anthranilic diamides similar to that observed with native receptors. Ligand-binding studies with radiolabeled ryanodine and radiolabeled anthranilic diamide in Periplaneta americana reveal a single, saturable binding site for this chemistry distinct from that of ryanodine. Further, calcium mobilization studies using mammalian cell lines indicate anthranilic diamides exhibit > 500-fold differential selectivity toward insect, over mammalian. receptors. Consequently, anthranilic diamides offer it novel pharmacological tool for calcium signaling research in addition to a unique alternative to existing pest-management strategies. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:196 / 214
页数:19
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