Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat

被引：20

作者：

Akhavan, Maziar M. ^{[1
]}

Emami-Abarghoie, Mitra ^{[1
]}

Sadighi-Moghaddam, Bizhan ^{[2
]}

Safari, Manouchehr ^{[3
]}

Yousefi, Yasaman ^{[1
]}

Rashidy-Pour, Ali ^{[4
]}

机构：

[1] Semnan Univ Med Sci, Sch Med, Fac Med, Dept Pharmacol, Semnan 3519899951, Iran

[2] Semnan Univ Med Sci, Sch Med, Dept Immunol, Semnan 3519899951, Iran

[3] Semnan Univ Med Sci, Sch Med, Dept Anat, Semnan 3519899951, Iran

[4] Semnan Univ Med Sci, Sch Med, Dept & Res Ctr Physiol, Lab Learning & Memory, Semnan 3519899951, Iran

来源：

BRAIN RESEARCH | 2008年 / 1232卷

关键词：

Voluntary running; Learning; Memory; Hippocampus; Angiotensin II; Sar(1) Thr(8)]-Angiotensin II;

D O I：

10.1016/j.brainres.2008.07.042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The beneficial effects of physical activity and exercise on brain functions such as improvement in learning and memory are well documented. The aim of this study was to examine the possible role of hippocampal angiotensin II receptors in voluntary exercise-induced enhancement of learning and memory in rat. In order to block the hippocampal angiotension II receptors, the animals received a single injection of latex microbeads for delivery of [Sar(1) Thr(8)]-Angiotensin II into the hippocampus. The animals were exposed to five consecutive nights of exercise and then their learning and memory were tested on the Morris water maze (MWM) task using a two-trial-per-day for five consecutive days. A probe trial was performed 2 days after the last training day. our results showed that hippocampal angiotensin 11 receptor blockade reversed the exercise-induced improvement in learning and memory in rat. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：132 / 138

页数：7

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