Alpha neurotoxins

被引：135

作者：

Barber, Carmel M. ^{[1
]}

Isbister, Geoffrey K. ^{[1
,2
]}

Hodgson, Wayne C. ^{[1
]}

机构：

[1] Monash Univ, Monash Venom Grp, Dept Pharmacol, Clayton, Vic 3800, Australia

[2] Univ Newcastle, Discipline Clin Pharmacol, Newcastle, NSW 2300, Australia

来源：

TOXICON | 2013年 / 66卷

关键词：

Nicotinic receptors; Postsynaptic neurotoxins; Skeletal muscle; Snake venom; Antagonist; AMINO-ACID-SEQUENCE; NICOTINIC ACETYLCHOLINE-RECEPTOR; LONG-CHAIN NEUROTOXIN; SITE-DIRECTED MUTAGENESIS; AUSTRALIAN ELAPID SNAKE; COMMON-DEATH-ADDER; PHARMACOLOGICAL CHARACTERIZATION; POSTSYNAPTIC NEUROTOXIN; CRYSTAL-STRUCTURE; HIGH-AFFINITY;

D O I：

10.1016/j.toxicon.2013.01.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

alpha-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare mimetic' neurotoxins, they play an important role in the capture and/or killing of prey by binding to the nicotinic acetylcholine receptor on the skeletal muscle disrupting neurotransmissiorf. They are also thought to cause respiratory paralysis in envenomed humans. This review will discuss the historical background into the discovery, isolation, structure and mechanism of action of the alpha-neurotoxins, including targets and cellular outcomes, and then will examine the potential uses of alpha-neurotoxins as pharmacological tools and/or as drug leads. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：47 / 58

页数：12

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