Control of vertebrate left-right asymmetry by a snail-related zinc finger gene

被引：163

作者：

Isaac, A ^{[1
]}

Sargent, MG ^{[1
]}

Cooke, J ^{[1
]}

机构：

[1] NATL INST MED RES, LONDON NW7 1AA, ENGLAND

来源：

SCIENCE | 1997年 / 275卷 / 5304期

关键词：

D O I：

10.1126/science.275.5304.1301

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A gene encoding a zinc finger protein of the Snail family, cSnR, is expressed in the right-hand lateral mesoderm during normal chick development. Antisense disruption of cSnR function during the hours immediately preceding heart formation randomized the normally reliable direction of heart looping and subsequent embryo torsion. Implanted ectopic sources of intercellular signal proteins that are involved in establishing normal left-right information randomized the handedness of heart development and also altered the asymmetry of cSnR expression. cSnR thus appears to act downstream of these signals, or perhaps in parallel with the latest expressed of them, the Nodal protein, in controlling the anatomical asymmetry.

引用

页码：1301 / 1304

页数：4

共 31 条

[1]

BROWN NA, 1990, DEVELOPMENT, V110, P949

[2]

BROWN NA, 1990, DEVELOPMENT, V109, P1

[3]

CAMPBELL M, 1966, BRIT HEART J, V28, P472

[4] Relationship between asymmetric nodal expression and the direction of embryonic turning [J].