Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

被引：157

作者：

Layfield, R

Fergusson, J

Aitken, A

Lowe, J

Landon, M

Mayer, RJ

机构：

[1] QUEENS MED CTR,DEPT CLIN LAB SCI,NOTTINGHAM NG7 2UH,ENGLAND

[2] NATL INST MED RES,LAB PROT STRUCT,LONDON,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1996年 / 209卷 / 01期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; neurofibrillary tangle; paired helical filaments; Lewy body dementia; cortical Lewy body; 14-3-3; proteins; MAP kinase; immunohistochemistry;

D O I：

10.1016/0304-3940(96)12598-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localisation of 14-3-3 proteins compared to that of tau acid ubiquitin-protein conjugates in sections of hippocampus from Alzheimer's disease (AD) brains was examined by immunohistochemistry. In all cases (n = 10), anti-14-3-3 stained a proportion of neurofibrillary tangles (NFT). In general, NFT stained by anti-14-3-3 were smaller than those stained by anti-tau or anti-ubiquitin-protein conjugates and were more confined to the neuronal cell body. Occasionally, cortical Lewy bodies in cases of Lewy body dementia were also found to be 14-3-3-positive. Since 14-3-3 proteins are central to MAP kinase signalling, the results support the proposal that this pathway is in part responsible for the hyperphosphorylation of tau, which leads to the formation of the paired helical filaments seen in AD brains.

引用

页码：57 / 60

页数：4

共 18 条

[1] 14-3-3-ALPHA AND 14-3-3-DELTA ARE THE PHOSPHORYLATED FORMS OF RAF-ACTIVATING 14-3-3-BETA AND 14-3-3-ZETA - IN-VIVO STOICHIOMETRIC PHOSPHORYLATION IN BRAIN AT A SER-PRO-GLU-LYS MOTIF [J].