MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases

被引：78

作者：

Li, Si ^{[1
]}

Liang, Zhu ^{[1
]}

Xu, Liu ^{[2
]}

Zou, Fangdong ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Bioresources & Ecoenvironm, Minist Educ, Coll Life Sci, Chengdu 610064, Sichuan, Peoples R China

[2] SW Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2012年 / 360卷 / 1-2期

关键词：

MicroRNAs; MiRNA-21; Cancer; Cardiovascular diseases; TUMOR-SUPPRESSOR GENES; BREAST-CANCER; UP-REGULATION; MIR-21; EXPRESSION; REGULATES MIR-21; TGF-BETA; IN-VIVO; TARGETS; CELLS; INVASION;

D O I：

10.1007/s11010-011-1052-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

MiRNAs are a new class of small RNA molecules that regulate gene expression at the post-transcriptional and translational levels. MiRNAs have been implicated in the control of many vital biological processes including development, cell proliferation, differentiation, and apoptosis. A growing number of studies have shown that miRNAs also play an important role in carcinogenesis and other diseases. Among the miRNAs identified, miRNA-21 is dramatically up-regulated in cancer cells of various origins. It regulates a wide range of genes and pathways involved in cancer initiation, transformation, invasion, and metastasis. MiRNA-21 also acts as a pro-survival factor in cardiovascular diseases. Aberrant expression in these diseases makes miRNA-21 a potential marker for disease diagnosis and prognosis. This review highlights the complex roles that miRNA-21 plays in cancer and cardiovascular diseases and its potential clinical applications.

引用

收藏

页码：147 / 158

页数：12

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