Src and focal adhesion kinase as therapeutic targets in cancer

被引：148

作者：

Brunton, Valerie G. ^{[1
]}

Frame, Margaret C. ^{[1
]}

机构：

[1] Univ Edinburgh, Div Canc Biol, Inst Genet & Mol Med, Edinburgh EH4 2XR, Midlothian, Scotland

来源：

CURRENT OPINION IN PHARMACOLOGY | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1016/j.coph.2008.06.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting.

引用

收藏

页码：427 / 432

页数：6

相关论文

共 58 条

[1] Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling [J].

Avizienyte, E ;

Wyke, AW ;

Jones, RJ ;

McLean, GW ;

Westhoff, MA ;

Brunton, VG ;

Frame, MC .

NATURE CELL BIOLOGY, 2002, 4 (08) :632-638

[2] Cell adhesion and signalling by cadherins and Ig-CAMs in cancer [J].

Cavallaro, U ;

Christofori, G .

NATURE REVIEWS CANCER, 2004, 4 (02) :118-132

[3] SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of β-catenin and its nuclear signaling [J].

Coluccia, AML ;

Benati, D ;

Dekhil, H ;

De Filippo, A ;

Lan, C ;

Gambacorti-Passerini, C .

CANCER RESEARCH, 2006, 66 (04) :2279-2286

[4] Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1 [J].

Cordes, N. ;

Frickz, S. ;

Brunner, T. B. ;

Pilarsky, C. ;

Gruetzmann, R. ;

Siposs, B. ;

Kloeppels, G. ;

McKenna, W. G. ;

Bernhard, E. J. .

ONCOGENE, 2007, 26 (48) :6851-6862

[5] Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability [J].

Criscuoli, ML ;

Nguyen, M ;

Eliceiri, BP .

BLOOD, 2005, 105 (04) :1508-1514

[6] siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity [J].

Duxbury, MS ;

Ito, H ;

Zinner, MJ ;

Ashley, SW ;

Whang, EE .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2004, 198 (06) :953-959

[7] Inhibition of Src tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells [J].

Duxbury, MS ;

Ito, H ;

Zinner, MJ ;

Ashley, SW ;

Whang, EE .

CLINICAL CANCER RESEARCH, 2004, 10 (07) :2307-2318

[8] RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity [J].

Duxbury, MS ;

Ito, H ;

Benoit, E ;

Zinner, MJ ;

Ashley, SW ;

Whang, EE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 311 (03) :786-792

[9] Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability [J].

Eliceiri, BP ;

Paul, R ;

Schwartzberg, PL ;

Hood, JD ;

Leng, J ;

Cheresh, DA .

MOLECULAR CELL, 1999, 4 (06) :915-924

[10] Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src [J].

Ellis, LM ;

Staley, CA ;

Liu, WB ;

Fleming, RYD ;

Parikh, NU ;

Bucana, CD ;

Gallick, GE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (02) :1052-1057

← 1 2 3 4 5 6 →