Recent insights into the role of Notch signaling in tumorigenesis

被引：420

作者：

Leong, KG

Karsan, A

机构：

[1] British Columbia Canc Res Ctr, Dept Med Biophys, Vancouver, BC V5Z 1L3, Canada

[2] British Columbia Canc Res Ctr, Dept Pathol & Lab Med, Vancouver, BC V5Z 1L3, Canada

[3] Univ British Columbia, Expt Med Program, Vancouver, BC, Canada

[4] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

来源：

BLOOD | 2006年 / 107卷 / 06期

关键词：

D O I：

10.1182/blood-2005-08-3329

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Members of the Notch family of transmembrane receptors play an important role in cell fate determination. Over the past decade, a role for Notch in the pathogenesis of hematologic and solid malignancies has become apparent. Numerous cellular functions and microenvironmental cues associated with tumorigenesis are modulated by Notch signaling, including proliferation, apoptosis, adhesion, epithelial-to-mesenchymal transition, and angiogenesis. It is becoming increasingly evident that Notch signaling can be both oncogenic and tumor suppressive. This review highlights recent findings regarding the molecular and functional aspects of Notch-mediated neoplastic transformation. In addition, cellular mechanisms that potentially explain the complex role of Notch in tumorigenesis are discussed.

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收藏

页码：2223 / 2233

页数：11

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