Thermo- and pH-responsive gels for application in colon delivery systems

被引：24

作者：

Yoshida, M

Asano, M

Suwa, T

Katakai, R

机构：

[1] Takasaki Radiat Chem Res Estab, Japan Atom Energy Res Inst, Dept Mat Dev, Gunma 3701292, Japan

[2] Gunma Univ, Fac Engn, Dept Chem, Gunma 3768515, Japan

来源：

RADIATION PHYSICS AND CHEMISTRY | 1999年 / 55卷 / 5-6期

关键词：

D O I：

10.1016/S0969-806X(99)00210-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Swelling-controlled drug delivery copolymer gels were synthesized by introducing thermo- and pH-responsive methacryloyl-glycine (MA-Gly) of pi-I-responsive methacrylic acid (MA-Ac) into thermo-responsive acryloyl-L-proline ethyl ester (A-ProOEt). The threshold of swelling for copolymer gels consisting of A-ProOEt/MA-Gly and A-ProOEt/MA-Ac with a composition of 40/60 mol% was found to be pH 3.0 and pH 5.5, respectively, in buffer solutions at 37 degrees C. The diffusion characteristics of 2-(3-benzoylphenyl)propionic acid (ketoprofen) from such copolymer gels were evaluated in buffer solutions at pHs more than 5.5, and it was found that A-ProOEt/MA-Gly gel possessed a Case II transport, while the A-ProOEt/MA-Ac gel exhibited a non-Fickian (or anomalous) diffusion behavior under the same conditions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：677 / 680

页数：4

共 13 条

[1] SOLUTE AND PENETRANT DIFFUSION IN SWELLABLE POLYMERS .9. THE MECHANISMS OF DRUG RELEASE FROM PH-SENSITIVE SWELLING-CONTROLLED SYSTEMS [J].