Endogenous morphogens and fibrin bioscaffolds for stem cell therapeutics

被引：38

作者：

Anitua, Eduardo ^{[1
]}

Prado, Roberto ^{[1
]}

Orive, Gorka ^{[1
]}

机构：

[1] Eduardo Anitua Fdn, Vitoria, Spain

来源：

TRENDS IN BIOTECHNOLOGY | 2013年 / 31卷 / 06期

关键词：

PLATELET-RICH PLASMA; MESENCHYMAL STROMAL CELLS; FETAL BOVINE SERUM; TISSUE-ENGINEERED BONE; IN-VITRO; DISTRACTION OSTEOGENESIS; ADIPOSE-TISSUE; GROWTH-FACTOR; CALF SERUM; ANIMAL SERUM;

D O I：

10.1016/j.tibtech.2013.04.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Clinical translation of mesenchymal stem cells (MSCs) is leading to optimization of procedures for ex vivo expansion. Endogenous growth factors and fibrin scaffolds can be used to support MSC expansion and transplantation. Cell growth on a fibrin scaffold mimics the 3D environment of tissue and facilitates handling and subsequent transplantation. This approach is presented as an essential toolbox in the substitution of fetal bovine serum in all large-scale ex vivo processes, providing quick and safe expansion of MSCs. This paper reviews the state of the art of platelet-rich plasma technology applied to clinical use of stem cells, focusing on current technology and methods, new challenges, and controversies.

引用

收藏

页码：364 / 374

页数：11

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