Host factors and failure of interferon-α treatment in hepatitis C virus

被引：135

作者：

Gao, B ^{[1
]}

Hong, F ^{[1
]}

Radaeva, S ^{[1
]}

机构：

[1] NIAAA, Sect Liver Biol, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA

来源：

HEPATOLOGY | 2004年 / 39卷 / 04期

关键词：

D O I：

10.1002/hep.20139

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Failure of interferon-alpha (IFN-alpha) treatment in patients with chronic hepatitis C virus (HCV) infection is a challenging obstacle for clinical and experimental hepatology. Both viral and host factors have been implicated in reducing responsiveness to IFN-alpha therapy. The role of viral factors has been studied extensively and has been summarized in several review articles; however, much less attention has been paid to host factors. In this paper, we review evidence of host factor involvement in IFN-alpha treatment failure. We discuss possible underlying mechanisms responsible for these effects. Potential therapeutic strategies to enhance the effectiveness of IFN-alpha therapy for HCV are also proposed.

引用

页码：880 / 890

页数：11

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