Regulation of an Enzyme Cascade Reaction by a DNA Machine

被引：146

作者：

Xin, Ling ^{[1
]}

Zhou, Chao ^{[1
,2
]}

Yang, Zhongqiang ^{[1
]}

Liu, Dongsheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 18期

基金：

中国国家自然科学基金;

关键词：

DNA structures; molecular devices; enzymes; cascade reactions; DNA regulation; NANOSTRUCTURES;

D O I：

10.1002/smll.201300019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy for the regulation of enzyme cascade reaction efficiency by a DNA machine in vitro is presented. Two cascade enzymes (GOx and HRP) are attached to the DNA machine, and the enzyme cascade reaction shows much higher efficiency when the two enzymes are brought closer by the DNA machine than when they are distant. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3088 / 3091

页数：4

共 54 条

[1]

[Anonymous], 2011, ANGEW CHEM INT ED, V50, P3124

[2]

[Anonymous], 2010, ANGEW CHEM INT ED, V49, P1200

[3]

[Anonymous], 2007, ANGEW CHEM INT ED, V46, P3915

[4]

[Anonymous], 2001, ANGEW CHEM INT ED, V40, P4629

[5]

[Anonymous], 2011, ANGEW CHEM INT ED, V50, P11934

[6]

[Anonymous], 2012, ANGEW CHEM INT ED, V51, P11271

[7]

[Anonymous], 2010, ANGEW CHEM

[8]

[Anonymous], 2005, ANGEW CHEM INT ED, V44, P7635

[9]

Becker C.F.W., 2005, ANGEW CHEM INT EDIT, V117, P7808, DOI [10.1002/ange.200502908, DOI 10.1002/ANGE.200502908]

[10]

CHANCE B, 1956, ADV ENZYMOL REL S BI, V17, P65

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