Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci

被引：137

作者：

Horgan, Marianne ^{[2
]}

O'Flynn, Gary ^{[2
]}

Garry, Jennifer ^{[3
]}

Cooney, Jakki ^{[4
]}

Coffey, Aidan ^{[3
]}

Fitzgerald, Gerald F. ^{[2
,5
]}

Ross, R. Paul ^{[1
,5
]}

McAuliffe, Olivia

机构：

[1] TEAGASC, Moorepark Food Res Ctr, Ctr Biotechnol, Fermoy, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Cork, Ireland

[3] Cork Inst Technol, Dept Biol Sci, Cork, Ireland

[4] Univ Limerick, Dept Life Sci, Mat & Surface Sci Inst, Limerick, Ireland

[5] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2009年 / 75卷 / 03期

关键词：

ACUTE MYOCARDIAL-INFARCTION; GROUP-B STREPTOCOCCI; BACILLUS-ANTHRACIS; ENZYME CPL-1; BACTERIOPHAGE; AUREUS; ENDOLYSIN; PNEUMONIAE; STREPTOKINASE; ELIMINATION;

D O I：

10.1128/AEM.01831-08

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

A truncated derivative of the phage endolysin LysK containing only the CHAP ( cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

引用

页码：872 / 874

页数：3

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