Mechanisms regulating the ductus arteriosus

被引：180

作者：

Clyman, Ronald I. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

BIOLOGY OF THE NEONATE | 2006年 / 89卷 / 04期

关键词：

ductus arteriosus patency; regulation; ductus arteriosus; anatomic closure-histologic changes; hemodynamic and pulmonary alterations;

D O I：

10.1159/000092870

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e., necrotizing enterocolitis, intracranial hemorrhage, pulmonary edema/hemorrhage, bronchopulmonary dysplasia, and retinopathy) are associated with the presence of a PDA, but whether or not a PDA is responsible for their development is still unclear. In this review, comparative physiology between the full term and preterm newborn and the barriers preventing the necessary cascade of events leading to permanent constriction of the PDA are reviewed. Copyright (c) 2006 S. Karger AG, Basel.

引用

页码：330 / 335

页数：6

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