New acetylenic metabolites from the marine sponge Pellina triangculata

被引：37

作者：

Fu, X

Abbas, SA

Schmitz, FJ

Vidavsky, I

Gross, ML

Laney, M

Schatzman, RC

Cabuslay, RD

机构：

[1] UNIV OKLAHOMA, DEPT CHEM & BIOCHEM, NORMAN, OK 73019 USA

[2] WASHINGTON UNIV, DEPT CHEM, ST LOUIS, MO 63130 USA

[3] SYNTEX INC, DISCOVERY RES, INST BIOCHEM & CELL BIOL, PALO ALTO, CA 94304 USA

来源：

TETRAHEDRON | 1997年 / 53卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4020(96)01037-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six new acetylenic compounds, 1, 7-11, were isolated from the marine sponge Pellina triangulata. Structures were established using NMR spectroscopy and chemical degradation. Collisional activation decomposition (CAD) tandem mass spectrometry of the lithium adducts of the acetylenic compounds was applied to ascertain if charge-remote fragmentation would yield definitive information regarding the site of internal unsaturation in these polyfunctional compounds. Pellynic acid (1) inhibited inosine monophosphate dehydrogenase (IMPDH) in vitro. Copyright (C) 1996 Elsevier Science Ltd

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页码：799 / 814

页数：16

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