Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing

被引：35

作者：

Kweon, HaeYong ^{[1
]}

Yeo, Joo-hong ^{[1
]}

Lee, Kwang-gill ^{[1
]}

Lee, Hyun Chul ^{[2
,3
]}

Na, Hee Sam ^{[2
,3
]}

Won, Young Ho ^{[4
]}

Cho, Chong Su ^{[5
]}

机构：

[1] Natl Inst Agr Sci & Technol, Appl Sericulture & Apiculture Div, Suwon 441100, South Korea

[2] Chonnam Natl Univ, Dept Microbiol, Sch Med, Kwangju, South Korea

[3] Chonnam Natl Univ, Res Inst Med Sci, Sch Med, Kwangju, South Korea

[4] Chonnam Natl Univ, Dept Dermatol, Sch Med, Kwangju, South Korea

[5] Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151742, South Korea

来源：

BIOMEDICAL MATERIALS | 2008年 / 3卷 / 03期

关键词：

D O I：

10.1088/1748-6041/3/3/034115

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Semi-interpenetrating polymer networks (SIPNs) composed of silk fibroin (SF) and poly(ethylene glycol) (PEG) were prepared by photopolymerization of a PEG macromer in the presence of SF to improve the mechanical properties of SF sponge as wound dressing. The morphological structure of the SF/PEG SIPNs was observed to be composed of an interconnected microporous surface and a cross-sectional area. SF/PEG SIPNs showed non-cytotoxicity evaluated by a cell proliferation method using L929 fibroblasts. Wound contraction treated with SF/PEG SIPNs sponges was faster than that of Vaseline gauze as a control. Histological observation confirmed that the deposition of collagen in the dermis was organized by covering the wound area with SF/PEG SIPNs. The above results indicated that SF/PEG SIPNs could be used as wound dressing.

引用

页数：5

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