Leveraging Epidemiology and Clinical Studies of Cancer Outcomes: Recommendations and Opportunities for Translational Research

被引：44

作者：

Elena, Joanne W. ^{[1
]}

Travis, Lois B. ^{[3
,4
]}

Simonds, Naoko I. ^{[1
]}

Ambrosone, Christine B. ^{[5
]}

Ballard-Barbash, Rachel ^{[1
]}

Bhatia, Smita ^{[6
]}

Cerhan, James R. ^{[7
]}

Hartge, Patricia ^{[2
]}

Heist, Rebecca S. ^{[8
]}

Kushi, Lawrence H. ^{[9
]}

Lash, Timothy L. ^{[10
,11
]}

Morton, Lindsay M. ^{[2
]}

Onel, Kenan ^{[12
]}

Pierce, John P. ^{[13
]}

Robison, Leslie L. ^{[14
]}

Rowland, Julia H.

Schrag, Deborah ^{[15
]}

Sellers, Thomas A. ^{[16
]}

Seminara, Daniela ^{[1
]}

Shu, Xiao Ou ^{[17
,18
]}

Thomas, Nancy E. ^{[19
]}

Ulrich, Cornelia M. ^{[20
,21
,22
]}

Freedman, Andrew N. ^{[1
]}

机构：

[1] NCI, Div Canc Control & Populat Sci, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[2] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[3] Univ Rochester, Med Ctr, Rubin Ctr Canc Survivorship, Rochester, NY 14642 USA

[4] Univ Rochester, Med Ctr, James P Wilmot Canc Ctr, Dept Radiat Oncol, Rochester, NY 14642 USA

[5] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[6] City Hope Natl Med Ctr, Dept Populat Sci, Duarte, CA USA

[7] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[8] Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA

[9] Kaiser Permanente No Calif, Div Res, Oakland, CA USA

[10] Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark

[11] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA

[12] Univ Chicago, Dept Pediat, Sect Hematol Oncol, Chicago, IL 60637 USA

[13] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA

[14] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA

[15] Dana Farber Canc Inst, Ctr Outcomes & Policy Res, Dept Adult Oncol, Boston, MA 02115 USA

[16] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[17] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA

[18] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[19] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[20] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA

[21] German Canc Res Ctr, Heidelberg, Germany

[22] Natl Ctr Tumor Dis, Heidelberg, Germany

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2013年 / 105卷 / 02期

关键词：

LONG-TERM SURVIVORS; 2ND MALIGNANT NEOPLASMS; DISEASE-FREE SURVIVAL; TREATMENT-RELATED TOXICITY; B-CELL LYMPHOMA; BREAST-CANCER; CHILDHOOD-CANCER; FOLLICULAR LYMPHOMA; GENE POLYMORPHISMS; PHYSICAL-ACTIVITY;

D O I：

10.1093/jnci/djs473

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As the number of cancer survivors continues to grow, research investigating the factors that affect cancer outcomes, such as disease recurrence, risk of second malignant neoplasms, and the late effects of cancer treatments, becomes ever more important. Numerous epidemiologic studies have investigated factors that affect cancer risk, but far fewer have addressed the extent to which demographic, lifestyle, genomic, clinical, and psychosocial factors influence cancer outcomes. To identify research priorities as well as resources and infrastructure needed to advance the field of cancer outcomes and survivorship research, the National Cancer Institute sponsored a workshop titled "Utilizing Data from Cancer Survivor Cohorts: Understanding the Current State of Knowledge and Developing Future Research Priorities" on November 3, 2011, in Washington, DC. This commentary highlights recent findings presented at the workshop, opportunities to leverage existing data, and recommendations for future research, data, and infrastructure needed to address high priority clinical and research questions. Multidisciplinary teams that include epidemiologists, clinicians, biostatisticians, and bioinformaticists will be essential to facilitate future cancer outcome studies focused on improving clinical care of cancer patients, identifying those at high risk of poor outcomes, and implementing effective interventions to ultimately improve the quality and duration of survival. J Natl Cancer Inst ;2013;105:85-94

引用

页码：85 / 94

页数：10

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