Tissue engineering for bone defect heating: An update on a multi-component approach

被引：162

作者：

Drosse, Inga ^{[1
]}

Volkmer, Elias ^{[1
]}

Capanna, Rodolfo ^{[2
]}

De Biase, Pietro ^{[2
]}

Mutschler, Wolf ^{[1
]}

Schieker, Matthias ^{[1
]}

机构：

[1] Univ Munich LMU, Dept Surg, D-80336 Munich, Germany

[2] Azienda Osped Univ Careggi, Dept Orthopaed, Div Orthopaed Oncol & Reconstruct Surg, CTO, Florence, Italy

来源：

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2008年 / 39卷

关键词：

Tissue engineering of bone; Mesenchymal stem cells; Scaffolds; Genetic engineering; Clinical application;

D O I：

10.1016/S0020-1383(08)70011-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

The need for an interdisciplinary approach in order to establish new therapeutic strategies for the therapy of bone defects has been acknowledged by the scientific community for many years. This awareness makes itself felt when looking at the multitude of approaches - ranging from cell-based to scaffold-based strategies and also including the use of osteogenic growth factors and genetic engineering that are currently being combined to assess their potential to develop effective concepts for the treatment of extensive loss of osseous tissue. With a strong focus on the preclinical research in this field, the goal of this review is to give an update on the multi-component approaches that are currently being investigated in tissue engineering of bone. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：S9 / S20

页数：12

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