IL36RN Mutations in Generalized Pustular Psoriasis: Just the Tip of the Iceberg?

被引：51

作者：

Capon, Francesca ^{[1
]}

机构：

[1] Kings Coll London, Div Genet & Mol, London, England

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2013年 / 133卷 / 11期

关键词：

D O I：

10.1038/jid.2013.361

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

As IL36RN mutations are a cause of generalized pustular psoriasis (GPP), three recent investigations attempted to correlate the IL36RN genotype with GPP clinical presentations. These studies found that IL36RN mutations account for only a fraction of GPP cases presenting with concomitant psoriasis vulgaris (PV; common or typical psoriasis). Pathogenic alleles were also found in control populations, indicating that environmental triggers and/or modifier genes may contribute to the disease.

引用

页码：2503 / 2504

页数：2

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