Colon cancer stem cells: implications for prevention and therapy

被引：88

作者：

Huang, Emina H. ^{[1
]}

Wicha, Max S. ^{[2
]}

机构：

[1] Univ Florida, Dept Surg, Gainesville, FL 32209 USA

[2] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2008年 / 14卷 / 11期

关键词：

D O I：

10.1016/j.molmed.2008.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The recent identification of colon cancer tumor-initiating cells adds further support to the cancer stem cell hypothesis. Ongoing basic and translational research efforts are aimed at gaining an increased understanding of the biology of these cells, as well as methods of targeting them. In addition, the relationship between colon carcinogenesis and inflammatory conditions, such as long-standing colitis and inherited syndromes, might be linked to the effect of the processes on stem cells in the colon. This review summarizes current literature on colon cancer stem cells and proposes strategies aimed at targeting these cells for colon cancer prevention and therapy.

引用

收藏

页码：503 / 509

页数：7

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