High IL-10 production by aged AIDS patients is related to high frequency of Tr-1 phenotype and low in vitro viral replication

被引：7

作者：

Andrade, Regis M. ^{[1
,2
]}

Hygino, Joana ^{[1
]}

Kasahara, Taissa M. ^{[1
]}

Vieira, Morgana M. ^{[1
]}

Xavier, Luciana F. ^{[1
]}

Blanco, Bernardo ^{[1
]}

Damasco, Paulo V. ^{[2
]}

Silva, Rodrigo M. ^{[3
]}

Lima, Dirce B. ^{[2
]}

Oliveira, Ariane L. ^{[4
]}

Lemos, Alberto S. ^{[5
]}

Andrade, Arnaldo F. B. ^{[3
]}

Bento, Cleonice A. M. ^{[1
]}

机构：

[1] Univ Fed Estado Rio de Janeiro, Dept Microbiol & Parasitol, BR-20261040 Rio De Janeiro, RJ, Brazil

[2] Univ Estado Rio De Janeiro, Sch Med, Discipline Infect & Parasit Dis, Rio De Janeiro, Brazil

[3] Univ Estado Rio De Janeiro, Sch Med, Dept Microbiol Immunol & Parasitol, Rio De Janeiro, Brazil

[4] Univ Fed Rio de Janeiro, Univ Hosp, Inst Oswaldo Cruz, Leprosy Lab, BR-21941 Rio De Janeiro, Brazil

[5] Univ Fed Rio de Janeiro, Univ Hosp, Dept Infect & Parasit Dis, BR-21941 Rio De Janeiro, Brazil

来源：

CLINICAL IMMUNOLOGY | 2012年 / 145卷 / 01期

关键词：

HIV; Aging; Anti-retroviral therapy; IL-10; FoxP3; CD152; REGULATORY T-CELLS; NECROSIS-FACTOR-ALPHA; HIV REPLICATION; ANTIRETROVIRAL THERAPY; INFECTION; DEPLETION; INTERLEUKIN-10; DYSFUNCTION; SENESCENCE; EXPRESSION;

D O I：

10.1016/j.clim.2012.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This work aims to elucidate the effects of age and HIV-1 infection on the frequency and function of T cell subsets in response to HIV-specific and non-specific stimuli. As compared with the younger AIDS group, the frequencies of naive and central memory T cells were significantly lower in aged AIDS patients. Although there was also a dramatic loss of classical CD4(+)FoxP3(+)CD25(+)Treg cells in this patient group, high frequencies of IL-10-producing CD4(+)FoxP3(-) T cells were observed. In our system, the increased production of IL-10 in aged AIDS patients was mainly derived from Env-specific CD4(+)FoxP3(-)CD152(+) T cells. Interestingly, while the blockade of IL-10 activity by monoclonal antibody clearly enhanced the release of IL-6 and IL-1 beta by Env-stimulated PBMC cultures from aged AIDS patients, this monoclonal antibody enhanced in vitro HIV-1-replication. In conclusion, HIV infection and aging undoubtedly contribute synergistically to a complex immune dysfunction in T cell compartment of HAART-treated older HIV-infected individuals. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：31 / 43

页数：13

共 38 条

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