Total synthesis of ciguatoxin CTX3C

被引：224

作者：

Hirama, M ^{[1
]}

Oishi, T

Uehara, H

Inoue, M

Maruyama, M

Guri, H

Satake, M

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

[2] Japan Sci & Technol Corp, CREST, Sendai, Miyagi 9808578, Japan

[3] Tohoku Univ, Grad Sch Life Sci, Dept Appl Bioorgan Chem, Sendai, Miyagi 9808555, Japan

来源：

SCIENCE | 2001年 / 294卷 / 5548期

关键词：

D O I：

10.1126/science.1065757

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

More than 20,000 people suffer annually from ciguatera seafood poisoning in subtropical and tropical regions. The extremely Low content of the causative neurotoxins, designated as ciguatoxins, in fish has hampered the isolation, detailed biological studies, and preparation of anti-ciguatoxin antibodies for detecting these toxins. The large (3 nanometers long) and complicated molecular structure of ciguatoxins has impeded chemists from completing their total synthesis. Our highly convergent strategic approach featuring the chemoselective ring-closing metathesis reaction as a key tactic has enabled the total synthesis of ciguatoxin CTX3C, which will provide a practical supply for further studies.

引用

页码：1904 / 1907

页数：4

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