Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp A92-308110 -: II.: Structure elucidation, stereochemistry and physico-chemical properties

被引：97

作者：

Fehr, T ^{[1
]}

Kallen, J ^{[1
]}

Oberer, L ^{[1
]}

Sanglier, JJ ^{[1
]}

Schilling, W ^{[1
]}

机构：

[1] Novartis Pharma Inc, Res, Dept Core Technol, CH-4002 Basel, Switzerland

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 05期

关键词：

D O I：

10.7164/antibiotics.52.474

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel class of macrolides, the sanglifehrins, was discovered by screening of actinomycete strains with a cyclophilin-binding assay. The chemical structures and absolute stereochemistries of the sanglifehrins A, B, C and D were determined unambiguously by NMR-techniques and by X-ray crystallography of the complex with cyclophilin A. Sanglifehrin A consists of a 22-membered macrocycle containing a tripeptide subunit and features in position 23 a chain of nine carbon atoms bearing a spirocyclic substituent. Sanglifehrins A and B are genuine metabolites whereas sanglifehrins C and D are artefacts.

引用

页码：474 / 479

页数：6

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Sanglier, JJ ;

Quesniaux, V ;

Fehr, T ;

Hofmann, H ;

Mahnke, M ;

Memmert, K ;

Schuler, W ;

Zenke, G ;

Gschwind, L ;

Maurer, C ;

Schilling, W .

JOURNAL OF ANTIBIOTICS, 1999, 52 (05) :466-473

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